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    ZCCHC10 zinc finger CCHC-type containing 10 [ Homo sapiens (human) ]

    Gene ID: 54819, updated on 5-Mar-2024

    Summary

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    Official Symbol
    ZCCHC10provided by HGNC
    Official Full Name
    zinc finger CCHC-type containing 10provided by HGNC
    Primary source
    HGNC:HGNC:25954
    See related
    Ensembl:ENSG00000155329 AllianceGenome:HGNC:25954
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable nucleic acid binding activity and zinc ion binding activity. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in lymph node (RPKM 8.3), testis (RPKM 8.2) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    5q31.1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (132996985..133026549, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (133516746..133546308, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (132332677..132362241, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16344 Neighboring gene AFF4 divergent transcript Neighboring gene small nuclear ribonucleoprotein U4/U6.U5 subunit 27 pseudogene Neighboring gene cytochrome c oxidase subunit NDUFA4-like Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23097 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16345 Neighboring gene Sharpr-MPRA regulatory region 5371 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:132386992-132387954 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:132388919-132389881 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:132393803-132394303 Neighboring gene heat shock protein family A (Hsp70) member 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23101 Neighboring gene uncharacterized LOC105379178

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. PITX1 protein interacts with ZCCHC10 to regulate hTERT mRNA transcription. Ohira T, et al. PLoS One, 2019. PMID 31404068, Free PMC Article
    2. ZCCHC10 suppresses lung cancer progression and cisplatin resistance by attenuating MDM2-mediated p53 ubiquitination and degradation. Ning Y, et al. Cell Death Dis, 2019 May 28. PMID 31138778, Free PMC Article
    3. Legionella effector AnkX interacts with host nuclear protein PLEKHN1. Yu X, et al. BMC Microbiol, 2018 Jan 5. PMID 29433439, Free PMC Article
    4. Dynamic protein-protein interaction wiring of the human spliceosome. Hegele A, et al. Mol Cell, 2012 Feb 24. PMID 22365833
    5. MAP4K Interactome Reveals STRN4 as a Key STRIPAK Complex Component in Hippo Pathway Regulation. Seo G, et al. Cell Rep, 2020 Jul 7. PMID 32640226, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ZCCHC10 exerts its tumor-suppressive effects by stabilizing the p53 protein and can be used a potential prognostic marker and therapeutic target in lung adenocarcinoma.
      Title: ZCCHC10 suppresses lung cancer progression and cisplatin resistance by attenuating MDM2-mediated p53 ubiquitination and degradation.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ20094

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger CCHC domain-containing protein 10
    Names
    zinc finger, CCHC domain containing 10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001300816.3 → NP_001287745.1  zinc finger CCHC domain-containing protein 10 isoform 1

      See identical proteins and their annotated locations for NP_001287745.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AK000101, AK300543, BC022443
      Consensus CDS
      CCDS75301.1
      UniProtKB/Swiss-Prot
      Q8TBK6, Q9NXR4
      Related
      ENSP00000423276.1, ENST00000509437.6
      Conserved Domains (1) summary
      pfam13917
      Location:39 → 76
      zf-CCHC_3; Zinc knuckle

    2. NM_001300817.3 → NP_001287746.1  zinc finger CCHC domain-containing protein 10 isoform 2

      See identical proteins and their annotated locations for NP_001287746.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' terminal exon, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
      Source sequence(s)
      AK000101, AK122970, AK300543, BC022443
      Consensus CDS
      CCDS78060.1
      UniProtKB/TrEMBL
      B3KVL5
      Related
      ENSP00000347533.2, ENST00000355372.6
      Conserved Domains (1) summary
      pfam13917
      Location:39 → 76
      zf-CCHC_3; Zinc knuckle

    3. NM_001300818.3 → NP_001287747.1  zinc finger CCHC domain-containing protein 10 isoform 3

      See identical proteins and their annotated locations for NP_001287747.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1, resulting in an isoform (3) that is shorter than isoform 1.
      Source sequence(s)
      AK000101, AK300543, BC022443, BU165290
      UniProtKB/Swiss-Prot
      Q8TBK6
      UniProtKB/TrEMBL
      B4DU89
      Conserved Domains (1) summary
      pfam13917
      Location:39 → 76
      zf-CCHC_3; Zinc knuckle

    4. NM_001300819.3 → NP_001287748.1  zinc finger CCHC domain-containing protein 10 isoform 5

      See identical proteins and their annotated locations for NP_001287748.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks an alternate in-frame exon in both the 5' and 3' coding regions, compared to variant 1, resulting in an isoform (5) that is shorter than isoform 1.
      Source sequence(s)
      AK000101, AK300543, BC022443
      Consensus CDS
      CCDS75300.1
      UniProtKB/TrEMBL
      G3XAM1
      Related
      ENSP00000427430.1, ENST00000513848.5
      Conserved Domains (1) summary
      pfam13917
      Location:17 → 54
      zf-CCHC_3; Zinc knuckle

    5. NM_001300822.3 → NP_001287751.1  zinc finger CCHC domain-containing protein 10 isoform 6

      See identical proteins and their annotated locations for NP_001287751.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) uses an alternate splice site that results in a frameshift in the 3' coding region, compared to variant 1, resulting in an isoform (6) that has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      AK000101, AK300543, BC022443, CB112418
      Consensus CDS
      CCDS75302.1
      UniProtKB/TrEMBL
      D6R9G7
      Related
      ENSP00000422111.1, ENST00000513541.5
      Conserved Domains (1) summary
      pfam13917
      Location:39 → 76
      zf-CCHC_3; Zinc knuckle

    6. NM_001308127.2 → NP_001295056.1  zinc finger CCHC domain-containing protein 10 isoform 9

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in an isoform (9) that is longer than isoform 1.
      Source sequence(s)
      AK000101, DA905071
      UniProtKB/Swiss-Prot
      Q8TBK6
      UniProtKB/TrEMBL
      B4DU89
      Conserved Domains (1) summary
      pfam13917
      Location:49 → 88
      zf-CCHC_3; Zinc knuckle

    7. NM_001308128.2 → NP_001295057.1  zinc finger CCHC domain-containing protein 10 isoform 10

      Status: VALIDATED

      Description
      Transcript Variant: This variant (10) lacks two alternate in-frame exons in the central coding region, compared to variant 1, resulting in an isoform (10) that is shorter than isoform 1.
      Source sequence(s)
      AK000101, DA345717
      UniProtKB/Swiss-Prot
      Q8TBK6

    8. NM_001308129.2 → NP_001295058.1  zinc finger CCHC domain-containing protein 10 isoform 11

      See identical proteins and their annotated locations for NP_001295058.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (11) lacks three alternate in-frame exons in the central coding region, compared to variant 1, resulting in an isoform (11) that is shorter than isoform 1.
      Source sequence(s)
      AK000101, AK300543, BI766652
      UniProtKB/Swiss-Prot
      Q8TBK6
      UniProtKB/TrEMBL
      B4DU89

    9. NM_001308130.2 → NP_001295059.1  zinc finger CCHC domain-containing protein 10 isoform 12

      See identical proteins and their annotated locations for NP_001295059.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (12) lacks an alternate in-frame exon in the 5' coding region, and uses an alternate splice site that results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (12) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      AK000101, AK300543, DA528172
      Consensus CDS
      CCDS78059.1
      UniProtKB/TrEMBL
      D6RHC2
      Related
      ENSP00000421071.1, ENST00000509008.1
      Conserved Domains (1) summary
      pfam13917
      Location:17 → 54
      zf-CCHC_3; Zinc knuckle

    10. NM_017665.4 → NP_060135.1  zinc finger CCHC domain-containing protein 10 isoform 4

      See identical proteins and their annotated locations for NP_060135.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in an isoform (4) that is shorter than isoform 1.
      Source sequence(s)
      AK000101, AK300543
      Consensus CDS
      CCDS4165.1
      UniProtKB/Swiss-Prot
      Q8TBK6
      UniProtKB/TrEMBL
      B4DU89
      Related
      ENSP00000324274.3, ENST00000324170.7
      Conserved Domains (1) summary
      pfam13917
      Location:17 → 54
      zf-CCHC_3; Zinc knuckle

    RNA

    1. NR_125337.3 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) uses an alternate splice site in the 5' terminal exon and lacks an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translation start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK000101, AK300543, BM470321

    2. NR_131766.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) uses an alternate splice site in the 5' terminal exon, lacks an internal exon but contains a different internal exon, and uses an alternate splice site in another internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK000101, AK300543, DA466245

    3. NR_131767.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (13) uses an alternate splice site in the 5' terminal exon, lacks an internal exon and uses an alternate splice site in another internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translation start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK000101, AK300543, BF983215

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      132996985..133026549 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011543502.2 → XP_011541804.1  zinc finger CCHC domain-containing protein 10 isoform X1

      Conserved Domains (1) summary
      pfam13917
      Location:49 → 88
      zf-CCHC_3; Zinc knuckle

    2. XM_011543503.3 → XP_011541805.1  zinc finger CCHC domain-containing protein 10 isoform X2

      Conserved Domains (1) summary
      pfam13917
      Location:49 → 88
      zf-CCHC_3; Zinc knuckle

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      133516746..133546308 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054352862.1 → XP_054208837.1  zinc finger CCHC domain-containing protein 10 isoform X1

    2. XM_054352863.1 → XP_054208838.1  zinc finger CCHC domain-containing protein 10 isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8TBK6.1 GenPept UniProtKB/Swiss-Prot:Q8TBK6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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