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    Zfp157 zinc finger protein 157 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360775, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Zfp157provided by RGD
    Official Full Name
    zinc finger protein 157provided by RGD
    Primary source
    RGD:1359435
    See related
    Ensembl:ENSRNOG00000001323 AllianceGenome:RGD:1359435
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    AZ61; RGD1359435
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to act upstream of or within lung alveolus development; mammary gland morphogenesis; and regulation of cell fate commitment. Orthologous to human ZNF157 (zinc finger protein 157). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 124.5), Thymus (RPKM 68.2) and 9 other tissues See more
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    Genomic context

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    Location:
    12q11
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (21356253..21393006, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (16248230..16279459, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (18461283..18495871, complement)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene sialophorin, pseudogene 5 Neighboring gene sialophorin, pseudogene 3 Neighboring gene uncharacterized LOC134481271 Neighboring gene olfactory receptor family 7 subfamily A member 43, pseudogene 1 Neighboring gene dehydrogenase/reductase X-linked

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of zinc finger encoding genes from the tumoral exocrine pancreatic cell line AR42J. Mesa K, et al. Cancer Lett, 1996 Jun 5. PMID 8635150
    2. The Stat6-regulated KRAB domain zinc finger protein Zfp157 regulates the balance of lineages in mammary glands and compensates for loss of Gata-3. Oliver CH, et al. Genes Dev, 2012 May 15. PMID 22588720, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within lung alveolus development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within mammary gland morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of cell fate commitment ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 157
    Names
    zinc finger protein 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001170404.1 → NP_001163875.1  zinc finger protein 157

      Status: VALIDATED

      Source sequence(s)
      FM039106, JAXUCZ010000012
      UniProtKB/TrEMBL
      D3ZFZ1
      Related
      ENSRNOP00000036664.4, ENSRNOT00000030757.6
      Conserved Domains (6) summary
      smart00349
      Location:4 → 64
      KRAB; krueppel associated box
      COG5048
      Location:182 → 528
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:382 → 402
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:436 → 458
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:4 → 43
      KRAB; KRAB box
      pfam13465
      Location:339 → 363
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      21356253..21393006 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063271474.1 → XP_063127544.1  zinc finger protein 157 isoform X4

    2. XM_039089570.2 → XP_038945498.1  zinc finger protein 157 isoform X2

      Conserved Domains (3) summary
      COG5048
      Location:234 → 390
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:350 → 370
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl02581
      Location:1 → 32
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

    3. XM_017598383.3 → XP_017453872.1  zinc finger protein 157 isoform X2

      Conserved Domains (3) summary
      COG5048
      Location:234 → 390
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:350 → 370
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl02581
      Location:1 → 32
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

    4. XM_039089573.2 → XP_038945501.1  zinc finger protein 157 isoform X2

      Conserved Domains (3) summary
      COG5048
      Location:234 → 390
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:350 → 370
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl02581
      Location:1 → 32
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

    5. XM_039089571.2 → XP_038945499.1  zinc finger protein 157 isoform X2

      Conserved Domains (3) summary
      COG5048
      Location:234 → 390
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:350 → 370
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl02581
      Location:1 → 32
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

    6. XM_039089575.2 → XP_038945503.1  zinc finger protein 157 isoform X5

      Conserved Domains (1) summary
      smart00349
      Location:4 → 64
      KRAB; krueppel associated box

    7. XM_063271473.1 → XP_063127543.1  zinc finger protein 157 isoform X2

    8. XM_039089568.2 → XP_038945496.1  zinc finger protein 157 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AIG3
      Related
      ENSRNOP00000093142.1
      Conserved Domains (3) summary
      smart00349
      Location:5 → 65
      KRAB; krueppel associated box
      COG5048
      Location:183 → 529
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:383 → 403
      ZF_C2H2; C2H2 Zn finger [structural motif]

    9. XM_039089574.2 → XP_038945502.1  zinc finger protein 157 isoform X3

      Conserved Domains (2) summary
      COG5048
      Location:152 → 308
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:268 → 288
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RNA

    1. XR_010056404.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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