ZFP36L2 ZFP36 ring finger protein like 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ZFP36L2provided by HGNC
Official Full Name: ZFP36 ring finger protein like 2provided by HGNC
Primary source: HGNC:HGNC:1108
See related: Ensembl:ENSG00000152518 MIM:612053; AllianceGenome:HGNC:1108
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: BRF2; ERF2; ERF-2; OOMD13; TIS11D; OZEMA13; RNF162C
Summary: This gene is a member of the TIS11 family of early response genes. Family members are induced by various agonists such as the phorbol ester TPA and the polypeptide mitogen EGF. The encoded protein contains a distinguishing putative zinc finger domain with a repeating cys-his motif. This putative nuclear transcription factor most likely functions in regulating the response to growth factors. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in thyroid (RPKM 108.0), appendix (RPKM 94.7) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 2p21

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	2	NC_000002.12 (43222402..43226606, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	2	NC_060926.1 (43227768..43231972, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	2	NC_000002.11 (43449541..43453745, complement)

Chromosome 2 - NC_000002.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Genetic association and functional validation of ZFP36L2 in non-syndromic orofacial cleft subtypes.
Title: Genetic association and functional validation of ZFP36L2 in non-syndromic orofacial cleft subtypes.
A novel homozygous variant in ZFP36L2 cause female infertility due to oocyte maturation defect.
Title: A novel homozygous variant in ZFP36L2 cause female infertility due to oocyte maturation defect.
TREC mediated oncogenesis in human immature T lymphoid malignancies preferentially involves ZFP36L2.
Title: TREC mediated oncogenesis in human immature T lymphoid malignancies preferentially involves ZFP36L2.
The RNA-Binding Proteins OAS1, ZFP36L2, and DHX58 Are Involved in the Regulation of CD44 mRNA Splicing in Colorectal Cancer Cells.
Title: The RNA-Binding Proteins OAS1, ZFP36L2, and DHX58 Are Involved in the Regulation of CD44 mRNA Splicing in Colorectal Cancer Cells.
Biallelic variants in ZFP36L2 cause female infertility characterised by recurrent preimplantation embryo arrest.
Title: Biallelic variants in ZFP36L2 cause female infertility characterised by recurrent preimplantation embryo arrest.
Genomic evolution and diverse models of systemic metastases in colorectal cancer.
Title: Genomic evolution and diverse models of systemic metastases in colorectal cancer.
ZFP36 Family Members Regulate the Proinflammatory Features of Psoriatic Dermal Fibroblasts.
Title: ZFP36 Family Members Regulate the Proinflammatory Features of Psoriatic Dermal Fibroblasts.
Silencing of ZFP36L2 increases sensitivity to temozolomide through G2/M cell cycle arrest and BAX mediated apoptosis in GBM cells.
Title: Silencing of ZFP36L2 increases sensitivity to temozolomide through G2/M cell cycle arrest and BAX mediated apoptosis in GBM cells.
RNA-Binding Protein ZFP36L2 Downregulates Helios Expression and Suppresses the Function of Regulatory T Cells.
Title: RNA-Binding Protein ZFP36L2 Downregulates Helios Expression and Suppresses the Function of Regulatory T Cells.
The results indicated that ZFP36L1 and ZFP36L2 play a negative role in cell proliferation; the underlying mechanisms might be mediated through a cyclin D-dependent and p53-independent pathway.
Title: ZFP36L1 and ZFP36L2 inhibit cell proliferation in a cyclin D-dependent and p53-independent manner.

Submit: New GeneRIF Correction See all GeneRIFs (22)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Oocyte maturation defect 13 MedGen: C5774268 OMIM: 620154 GeneReviews: Not available	not available

EBI GWAS Catalog

Description
Genome-wide association study identifies susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21 and 9q33.3. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SGC34340 (e-PCR)
- UniSTS:45837

D2S2709 (e-PCR)
- UniSTS:31039

D2S1494E (e-PCR)
- UniSTS:150337

RH66801 (e-PCR)
- UniSTS:43406

D8S1420E (e-PCR)
- UniSTS:151208

SHGC-30127 (e-PCR)
- UniSTS:81598

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables RNA binding	HDA more info	PubMed
enables mRNA 3'-UTR AU-rich region binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in 3'-UTR-mediated mRNA destabilization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in 3'-UTR-mediated mRNA destabilization	ISS Inferred from Sequence or Structural Similarity more info
involved_in ERK1 and ERK2 cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in T cell differentiation in thymus	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to epidermal growth factor stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to fibroblast growth factor stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to glucocorticoid stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to granulocyte macrophage colony-stimulating factor stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to transforming growth factor beta stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to tumor necrosis factor	IDA Inferred from Direct Assay more info	PubMed
involved_in definitive hemopoiesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in hemopoiesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in mRNA catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mRNA catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of fat cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of mitotic cell cycle phase transition	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of stem cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of B cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of mRNA stability	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of mRNA stability	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to wounding	IDA Inferred from Direct Assay more info	PubMed
involved_in somatic stem cell division	ISS Inferred from Sequence or Structural Similarity more info
involved_in somatic stem cell population maintenance	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
part_of ribonucleoprotein complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: mRNA decay activator protein ZFP36L2

Names: EGF-response factor 2; TPA-induced sequence 11d; ZFP36-like 2; butyrate response factor 2 (EGF-response factor 2); zinc finger protein 36, C3H type-like 1; zinc finger protein 36, C3H type-like 2; zinc finger protein 36, C3H1 type-like 2; zinc finger protein, C3H type, 36-like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_006887.5 → NP_008818.3 mRNA decay activator protein ZFP36L2

See identical proteins and their annotated locations for NP_008818.3

Status: REVIEWED

Source sequence(s)

AC010883, N67537

Consensus CDS

CCDS1811.1

UniProtKB/Swiss-Prot

P47974, Q53TB4, Q9BSJ3

Related

ENSP00000282388.3, ENST00000282388.4

Conserved Domains (2) summary

pfam00642
Location:154 → 179

zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)

pfam04553
Location:3 → 131

Tis11B_N; Tis11B like protein, N terminus