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    Plekhj1 pleckstrin homology domain containing J1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 314634, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Plekhj1provided by RGD
    Official Full Name
    pleckstrin homology domain containing J1provided by RGD
    Primary source
    RGD:1307213
    See related
    AllianceGenome:RGD:1307213
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in endosome organization; receptor recycling; and retrograde transport, endosome to Golgi. Predicted to be located in cytosol. Predicted to be active in early endosome; recycling endosome; and trans-Golgi network. Orthologous to human PLEKHJ1 (pleckstrin homology domain containing J1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 293.0), Thymus (RPKM 171.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    7q11
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (9566200..9570993)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (8915492..8920491)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (11784314..11786476)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase-like Neighboring gene junctional sarcoplasmic reticulum protein 1 Neighboring gene splicing factor 3A subunit 2 Neighboring gene anti-Mullerian hormone Neighboring gene DOT1 like histone lysine methyltransferase Neighboring gene uncharacterized LOC134479808 Neighboring gene adaptor related protein complex 3 subunit delta 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in endosome organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in receptor recycling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in retrograde transport, endosome to Golgi IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in early endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in recycling endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    pleckstrin homology domain-containing family J member 1
    Names
    pleckstrin homology domain containing, family J member 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108072.3 → NP_001101542.1  pleckstrin homology domain-containing family J member 1 isoform 1

      See identical proteins and their annotated locations for NP_001101542.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      B4F791
      Conserved Domains (1) summary
      cd13258
      Location:1 → 112
      PH_PLEKHJ1; Pleckstrin homology domain containing, family J member 1 Pleckstrin homology (PH) domain

    2. NM_001400972.1 → NP_001387901.1  pleckstrin homology domain-containing family J member 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A6K8G5

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      9566200..9570993
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039079013.2 → XP_038934941.1  pleckstrin homology domain-containing family J member 1 isoform X3

      Conserved Domains (1) summary
      cl17171
      Location:176 → 227
      PH-like; Pleckstrin homology-like domain

    2. XM_039079014.2 → XP_038934942.1  pleckstrin homology domain-containing family J member 1 isoform X4

      Conserved Domains (1) summary
      cl17171
      Location:176 → 227
      PH-like; Pleckstrin homology-like domain

    3. XM_039079011.2 → XP_038934939.2  pleckstrin homology domain-containing family J member 1 isoform X1

    4. XM_039079012.2 → XP_038934940.2  pleckstrin homology domain-containing family J member 1 isoform X2

    5. XM_039079015.2 → XP_038934943.1  pleckstrin homology domain-containing family J member 1 isoform X5

      Conserved Domains (1) summary
      cd13258
      Location:1 → 112
      PH_PLEKHJ1; Pleckstrin homology domain containing, family J member 1 Pleckstrin homology (PH) domain

    6. XM_063263425.1 → XP_063119495.1  pleckstrin homology domain-containing family J member 1 isoform X7

    7. XM_063263424.1 → XP_063119494.1  pleckstrin homology domain-containing family J member 1 isoform X6

    8. XM_063263426.1 → XP_063119496.1  pleckstrin homology domain-containing family J member 1 isoform X8

    Nucleotide Protein Strain
    Heading Accession and Version

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