Incenp inner centromere protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Incenpprovided by RGD
Official Full Name: inner centromere proteinprovided by RGD
Primary source: RGD:1305292
See related: Ensembl:ENSRNOG00000032929 AllianceGenome:RGD:1305292
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable protein serine/threonine kinase activator activity. Predicted to be involved in several processes, including meiotic spindle midzone assembly; metaphase plate congression; and positive regulation of protein serine/threonine kinase activity. Predicted to be located in several cellular components, including chromocenter; nuclear lumen; and pericentric heterochromatin. Predicted to be part of chromosome passenger complex. Predicted to be active in several cellular components, including kinetochore; meiotic spindle midzone; and midbody. Orthologous to human INCENP (inner centromere protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 127.6), Spleen (RPKM 95.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q43

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (215945558..216017247, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (206520655..206550575, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (225923448..225953384, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

RH137000 (e-PCR)
- UniSTS:219089

RH139063 (e-PCR)
- UniSTS:221149

MARC_3953-3954:996679214:1 (e-PCR)
- UniSTS:269294

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables molecular function activator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in chromosome segregation	ISO Inferred from Sequence Orthology more info
involved_in meiotic spindle midzone assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in metaphase chromosome alignment	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic cytokinesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic cytokinesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in central element	ISO Inferred from Sequence Orthology more info
located_in chromocenter	ISO Inferred from Sequence Orthology more info
part_of chromosome passenger complex	IBA Inferred from Biological aspect of Ancestor more info
part_of chromosome passenger complex	ISO Inferred from Sequence Orthology more info
located_in chromosome, centromeric region	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in kinetochore	IBA Inferred from Biological aspect of Ancestor more info
located_in kinetochore	ISO Inferred from Sequence Orthology more info
located_in lateral element	ISO Inferred from Sequence Orthology more info
is_active_in meiotic spindle midzone	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in microtubule cytoskeleton	ISO Inferred from Sequence Orthology more info
is_active_in midbody	IBA Inferred from Biological aspect of Ancestor more info
located_in midbody	ISO Inferred from Sequence Orthology more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
part_of pericentric heterochromatin	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in spindle	ISO Inferred from Sequence Orthology more info
located_in synaptonemal complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: inner centromere protein

Names: inner centromere protein antigens 135/155kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106335.1 → NP_001099805.1 inner centromere protein

See identical proteins and their annotated locations for NP_001099805.1

Status: PROVISIONAL

Source sequence(s)

CH473953

UniProtKB/TrEMBL

A6I000, D3ZXY1

Related

ENSRNOP00000071544.2, ENSRNOT00000077823.2

Conserved Domains (4) summary

pfam03941
Location:815 → 866

INCENP_ARK-bind; Inner centromere protein, ARK binding region

pfam12178
Location:6 → 41

INCENP_N; Chromosome passenger complex (CPC) protein INCENP N terminal

cd16269
Location:601 → 612

GBP_C; coiled coil [structural motif]

cl20817
Location:528 → 632

GBP_C; Guanylate-binding protein, C-terminal domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

215945558..216017247 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063286935.1 → XP_063143005.1 inner centromere protein isoform X3

UniProtKB/TrEMBL

A6I000
XM_063286932.1 → XP_063143002.1 inner centromere protein isoform X2
XM_006231025.3 → XP_006231087.1 inner centromere protein isoform X1

UniProtKB/TrEMBL

A0A8I5ZP23, A0A8I5ZZ56

Related

ENSRNOP00000080126.1

Conserved Domains (4) summary

pfam03941
Location:839 → 890

INCENP_ARK-bind; Inner centromere protein, ARK binding region

pfam12178
Location:30 → 65

INCENP_N; Chromosome passenger complex (CPC) protein INCENP N terminal

cd16269
Location:625 → 636

GBP_C; coiled coil [structural motif]

cl20817
Location:552 → 656

GBP_C; Guanylate-binding protein, C-terminal domain
XM_063286938.1 → XP_063143008.1 inner centromere protein isoform X3

UniProtKB/TrEMBL

A6I000
XM_063286940.1 → XP_063143010.1 inner centromere protein isoform X4