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    TRIQK triple QxxK/R motif containing [ Homo sapiens (human) ]

    Gene ID: 286144, updated on 5-Mar-2024

    Summary

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    Official Symbol
    TRIQKprovided by HGNC
    Official Full Name
    triple QxxK/R motif containingprovided by HGNC
    Primary source
    HGNC:HGNC:27828
    See related
    Ensembl:ENSG00000205133 AllianceGenome:HGNC:27828
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C8orf83; PRO0845; UPF0599
    Summary
    Predicted to be located in endoplasmic reticulum membrane. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in adrenal (RPKM 10.3), thyroid (RPKM 9.6) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    8q22.1
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (92883534..93017665, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (94008453..94091047, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (93895762..93978372, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC441369 Neighboring gene uncharacterized LOC124901978 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27616 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19356 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:93986327-93986595 Neighboring gene interferon regulatory factor 5 pseudogene 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:94050860-94051674 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27617 Neighboring gene microRNA 8084 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr8:94146448-94147647 Neighboring gene long intergenic non-protein coding RNA 2906 Neighboring gene uncharacterized LOC105375644

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. TRIQK, a novel family of small proteins localized to the endoplasmic reticulum membrane, is conserved across vertebrates. Onuma Y, et al. Zoolog Sci, 2008 Jul. PMID 18828657
    2. A novel p53 regulator, C16ORF72/TAPR1, buffers against telomerase inhibition. Benslimane Y, et al. Aging Cell, 2021 Apr. PMID 33660365, Free PMC Article
    3. SUMOylation of DDX39A Alters Binding and Export of Antiviral Transcripts to Control Innate Immunity. Shi P, et al. J Immunol, 2020 Jul 1. PMID 32393512
    4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ40637, DKFZp779L1068

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    triple QxxK/R motif-containing protein
    Names
    protein TRIQK
    triple repetitive-sequence of QXXK/R protein homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001171795.2 → NP_001165266.1  triple QxxK/R motif-containing protein

      See identical proteins and their annotated locations for NP_001165266.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1-7 all encode the same protein.
      Source sequence(s)
      BC110326, BQ009934, BX474727
      Consensus CDS
      CCDS55261.1
      UniProtKB/Swiss-Prot
      Q629K1
      Related
      ENSP00000430837.1, ENST00000518748.5
      Conserved Domains (1) summary
      pfam15168
      Location:1 → 52
      TRIQK; Triple QxxK/R motif-containing protein family

    2. NM_001171796.2 → NP_001165267.1  triple QxxK/R motif-containing protein

      See identical proteins and their annotated locations for NP_001165267.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1-7 all encode the same protein.
      Source sequence(s)
      BC031029, BC110326, BQ009934, DA093687
      Consensus CDS
      CCDS55261.1
      UniProtKB/Swiss-Prot
      Q629K1
      Related
      ENSP00000368138.5, ENST00000378861.9
      Conserved Domains (1) summary
      pfam15168
      Location:1 → 52
      TRIQK; Triple QxxK/R motif-containing protein family

    3. NM_001171797.2 → NP_001165268.1  triple QxxK/R motif-containing protein

      See identical proteins and their annotated locations for NP_001165268.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1-7 all encode the same protein.
      Source sequence(s)
      BC110326, BQ009934, DA093687, DQ351291
      Consensus CDS
      CCDS55261.1
      UniProtKB/Swiss-Prot
      Q629K1
      Related
      ENSP00000429517.1, ENST00000521988.6
      Conserved Domains (1) summary
      pfam15168
      Location:1 → 52
      TRIQK; Triple QxxK/R motif-containing protein family

    4. NM_001171798.2 → NP_001165269.1  triple QxxK/R motif-containing protein

      See identical proteins and their annotated locations for NP_001165269.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1-7 all encode the same protein.
      Source sequence(s)
      AK097956, BC110326, BQ009934, DA093687
      Consensus CDS
      CCDS55261.1
      UniProtKB/Swiss-Prot
      Q629K1
      Related
      ENSP00000428822.1, ENST00000520430.5
      Conserved Domains (1) summary
      pfam15168
      Location:1 → 52
      TRIQK; Triple QxxK/R motif-containing protein family

    5. NM_001171799.2 → NP_001165270.1  triple QxxK/R motif-containing protein

      See identical proteins and their annotated locations for NP_001165270.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 1. Variants 1-7 all encode the same protein.
      Source sequence(s)
      BC110326, BQ009934, DA191587
      Consensus CDS
      CCDS55261.1
      UniProtKB/Swiss-Prot
      Q629K1
      Related
      ENSP00000442030.1, ENST00000537541.1
      Conserved Domains (1) summary
      pfam15168
      Location:1 → 52
      TRIQK; Triple QxxK/R motif-containing protein family

    6. NM_001191035.2 → NP_001177964.1  triple QxxK/R motif-containing protein

      See identical proteins and their annotated locations for NP_001177964.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR, compared to variant 1. Variants 1-7 all encode the same protein.
      Source sequence(s)
      AC027242, AC117834, BQ009934, CB989812
      Consensus CDS
      CCDS55261.1
      UniProtKB/Swiss-Prot
      Q629K1
      Related
      ENSP00000429742.1, ENST00000524107.5
      Conserved Domains (1) summary
      pfam15168
      Location:1 → 52
      TRIQK; Triple QxxK/R motif-containing protein family

    7. NM_001191036.2 → NP_001177965.1  triple QxxK/R motif-containing protein

      See identical proteins and their annotated locations for NP_001177965.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR, compared to variant 1. Variants 1-7 all encode the same protein.
      Source sequence(s)
      AC027242, AC117834, BQ009934, DA115453
      Consensus CDS
      CCDS55261.1
      UniProtKB/Swiss-Prot
      Q629K1
      Related
      ENSP00000429381.1, ENST00000519969.5
      Conserved Domains (1) summary
      pfam15168
      Location:1 → 52
      TRIQK; Triple QxxK/R motif-containing protein family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      92883534..93017665 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047421713.1 → XP_047277669.1  triple QxxK/R motif-containing protein isoform X1

      UniProtKB/Swiss-Prot
      Q629K1

    2. XM_017013350.2 → XP_016868839.1  triple QxxK/R motif-containing protein isoform X1

      UniProtKB/Swiss-Prot
      Q629K1
      Related
      ENSP00000430992.1, ENST00000521617.5
      Conserved Domains (1) summary
      pfam15168
      Location:1 → 52
      TRIQK; Triple QxxK/R motif-containing protein family

    3. XM_017013347.2 → XP_016868836.1  triple QxxK/R motif-containing protein isoform X1

      UniProtKB/Swiss-Prot
      Q629K1
      Conserved Domains (1) summary
      pfam15168
      Location:1 → 52
      TRIQK; Triple QxxK/R motif-containing protein family

    4. XM_047421711.1 → XP_047277667.1  triple QxxK/R motif-containing protein isoform X1

      UniProtKB/Swiss-Prot
      Q629K1

    5. XM_024447136.2 → XP_024302904.1  triple QxxK/R motif-containing protein isoform X1

      UniProtKB/Swiss-Prot
      Q629K1
      Conserved Domains (1) summary
      pfam15168
      Location:1 → 52
      TRIQK; Triple QxxK/R motif-containing protein family

    6. XM_047421712.1 → XP_047277668.1  triple QxxK/R motif-containing protein isoform X1

      UniProtKB/Swiss-Prot
      Q629K1

    7. XM_017013349.2 → XP_016868838.1  triple QxxK/R motif-containing protein isoform X1

      UniProtKB/Swiss-Prot
      Q629K1
      Conserved Domains (1) summary
      pfam15168
      Location:1 → 52
      TRIQK; Triple QxxK/R motif-containing protein family

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      94008453..94091047 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054360331.1 → XP_054216306.1  triple QxxK/R motif-containing protein isoform X1

      UniProtKB/Swiss-Prot
      Q629K1

    2. XM_054360327.1 → XP_054216302.1  triple QxxK/R motif-containing protein isoform X1

      UniProtKB/Swiss-Prot
      Q629K1

    3. XM_054360328.1 → XP_054216303.1  triple QxxK/R motif-containing protein isoform X1

      UniProtKB/Swiss-Prot
      Q629K1

    4. XM_054360330.1 → XP_054216305.1  triple QxxK/R motif-containing protein isoform X1

      UniProtKB/Swiss-Prot
      Q629K1

    5. XM_054360329.1 → XP_054216304.1  triple QxxK/R motif-containing protein isoform X1

      UniProtKB/Swiss-Prot
      Q629K1

    6. XM_054360332.1 → XP_054216307.1  triple QxxK/R motif-containing protein isoform X1

      UniProtKB/Swiss-Prot
      Q629K1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q629K1.1 GenPept UniProtKB/Swiss-Prot:Q629K1

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