RBM14 RNA binding motif protein 14 [Homo sapiens (human)] - Gene

Summary

Official Symbol: RBM14provided by HGNC
Official Full Name: RNA binding motif protein 14provided by HGNC
Primary source: HGNC:HGNC:14219
See related: Ensembl:ENSG00000239306 MIM:612409; AllianceGenome:HGNC:14219
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: SIP; COAA; PSP2; SYTIP1; TMEM137
Summary: This gene encodes a ribonucleoprotein that functions as a general nuclear coactivator, and an RNA splicing modulator. This protein contains two RNA recognition motifs (RRM) at the N-terminus, and multiple hexapeptide repeat domain at the C-terminus that interacts with thyroid hormone receptor-binding protein (TRBP), and is required for transcription activation. Alternatively spliced transcript variants encoding different isoforms (with opposing effects on transcription) have been described for this gene. [provided by RefSeq, Oct 2011]
Annotation information: Note: The nomenclature TMEM137, transmembrane protein 137 was assigned to BC024260, which is now thought to represent the 3' UTR of RBM14. [15 Aug 2008]
Expression: Ubiquitous expression in testis (RPKM 11.0), lymph node (RPKM 7.8) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 11q13.2

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	11	NC_000011.10 (66616630..66629934)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	11	NC_060935.1 (66612875..66626179)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	11	NC_000011.9 (66384101..66397405)

Chromosome 11 - NC_000011.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NONO promotes gallbladder cancer cell proliferation by enhancing oncogenic RNA splicing of DLG1 through interaction with IGF2BP3/RBM14.
Title: NONO promotes gallbladder cancer cell proliferation by enhancing oncogenic RNA splicing of DLG1 through interaction with IGF2BP3/RBM14.
The RNA-binding motif protein 14 regulates telomere integrity at the interface of TERRA and telomeric R-loops.
Title: The RNA-binding motif protein 14 regulates telomere integrity at the interface of TERRA and telomeric R-loops.
RNA-binding protein 14 promotes phase separation to sustain prostate specific antigen expression under androgen deprivation in human prostate cancer.
Title: RNA-binding protein 14 promotes phase separation to sustain prostate specific antigen expression under androgen deprivation in human prostate cancer.
RBM14 as a novel epigenetic-activated tumor oncogene is implicated in the reprogramming of glycolysis in lung cancer.
Title: RBM14 as a novel epigenetic-activated tumor oncogene is implicated in the reprogramming of glycolysis in lung cancer.
METTL3 promotes m6A hypermethylation of RBM14 via YTHDF1 leading to the progression of hepatocellular carcinoma.
Title: METTL3 promotes m6A hypermethylation of RBM14 via YTHDF1 leading to the progression of hepatocellular carcinoma.
canonical nonhomologous end joining pathway utilizes damage-induced transcription and intrinsically disordered protein RBM14 for efficient repair of double-strand breaks.
Title: Intrinsically disordered protein RBM14 plays a role in generation of RNA:DNA hybrids at double-strand break sites.
The influenza A virus NS1 protein is both necessary and sufficient for RBM14 relocalization, and relocalization also requires the double-stranded RNA (dsRNA) binding capacity of NS1.
Title: Nucleolar Relocalization of RBM14 by Influenza A Virus NS1 Protein.
RBM14 plays crucial role in regulation of non-homologous end joining upon DNA damage.
Title: RNA-binding protein RBM14 regulates dissociation and association of non-homologous end joining proteins.
RBM14 connects key paraspeckle subcomplexes via interactions mediated by its prion-like domain.
Title: Prion-like domains in RNA binding proteins are essential for building subnuclear paraspeckles.
This study identifies a cellular protein named RBM14 that is associated with XPO1 (CRM1), a nuclear protein that binds to the HIV-1 Rev protein and mediates nuclear export of incompletely spliced HIV-1 viral RNAs
Title: Mining the human complexome database identifies RBM14 as an XPO1-associated protein involved in HIV-1 Rev function.

Submit: New GeneRIF Correction See all GeneRIFs (21)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Rev	rev	The localization of RBM14 to the nuclear paraspeckles is required for RBM14 enhancement of HIV-1 Rev activity in cells	PubMed
	rev	Co-immunoprecipitation analysis demonstrates that endogenous RBM14 associates with HIV-1 Rev, XPO1, and p54/NRB in cells	PubMed
	rev	Depletion of RBM14 inhibits HIV-1 Rev activity, leading to reduced HIV-1 p24 expression from the Rev-mediated reporter plasmid	PubMed
Tat	tat	RNA binding motif protein 14 (RBM14) is identified to interact with HIV-1 Tat mutant Nullbasic in HeLa cells by LC MS/MS	PubMed
capsid	gag	Depletion of RBM14 inhibits HIV-1 Rev activity, leading to reduced HIV-1 p24 expression from the Rev-mediated reporter plasmid	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

L17705 (e-PCR)
- UniSTS:66091

G35510 (e-PCR)
- UniSTS:44150

SHGC-33744 (e-PCR)
- UniSTS:41107

A008Z47 (e-PCR)
- UniSTS:82126

RH47022 (e-PCR)
- UniSTS:29162

D5S1597E (e-PCR)
- UniSTS:151019

D13S1667 (e-PCR)
- UniSTS:65013

Readthrough RBM14-RBM4

Readthrough gene: RBM14-RBM4, Included gene: RBM4

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables RNA binding	HDA more info	PubMed
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA binding	IEA Inferred from Electronic Annotation more info
enables nuclear receptor coactivator activity	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables splicing factor binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in activation of innate immune response	IDA Inferred from Direct Assay more info	PubMed
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in centriole assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gastrulation	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of centriole replication	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of response to DNA integrity checkpoint signaling	IEA Inferred from Electronic Annotation more info
involved_in response to hormone	TAS Traceable Author Statement more info	PubMed
involved_in transcription initiation-coupled chromatin remodeling	IPI Inferred from Physical Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in nuclear speck	IBA Inferred from Biological aspect of Ancestor more info
located_in nuclear speck	IDA Inferred from Direct Assay more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of ribonucleoprotein complex	TAS Traceable Author Statement more info	PubMed
part_of transcription regulator complex	IPI Inferred from Physical Interaction more info	PubMed

General protein information

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Preferred Names: RNA-binding protein 14

Names: RRM-containing coactivator activator/modulator; SYT-interacting protein; paraspeckle protein 2; synaptotagmin-interacting protein; transmembrane protein 137

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_030394.1 RefSeqGene

Range

5049..18353

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001198836.2 → NP_001185765.1 RNA-binding protein 14 isoform 2

See identical proteins and their annotated locations for NP_001185765.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate donor splice site at an internal coding exon compared to variant 1. This results in a frame-shift and an isoform (2, also known as CoAM or coactivator modulator) with a distinct and shorter C-terminus compared to isoform 1. This isoform lacks the TRBP-interacting domain, and functions as a transcriptional repressor by inhibiting the activity of isoform 1 (PMID:11443112).

Source sequence(s)

AF315633, AP001157

Consensus CDS

CCDS55772.1

UniProtKB/TrEMBL

A0A0S2Z567

Related

ENSP00000377548.3, ENST00000393979.3

Conserved Domains (2) summary

cd12609
Location:79 → 146

RRM2_CoAA; RNA recognition motif 2 (RRM2) found in vertebrate RRM-containing coactivator activator/modulator (CoAA)

cl17169
Location:1 → 71

RRM_SF; RNA recognition motif (RRM) superfamily
NM_001198837.2 → NP_001185766.1 RNA-binding protein 14 isoform 3

See identical proteins and their annotated locations for NP_001185766.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks an internal coding exon compared to variant 1. This results in a frame-shift and an isoform (3, also known as CoAR or coactivator regulator) with a distinct and shorter C-terminus compared to isoform 1.

Source sequence(s)

AP001157, DB044990, DQ294957

Consensus CDS

CCDS55773.1

UniProtKB/TrEMBL

A0A0S2Z5V2, F8WDX3

Related

ENSP00000386995.4, ENST00000409738.4

Conserved Domains (1) summary

cl17169
Location:1 → 71

RRM_SF; RNA recognition motif (RRM) superfamily
NM_006328.4 → NP_006319.1 RNA-binding protein 14 isoform 1

See identical proteins and their annotated locations for NP_006319.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1, also known as CoAA or coactivator activator).

Source sequence(s)

AK021768, AP001157, DB044990

Consensus CDS

CCDS8147.1

UniProtKB/Swiss-Prot

B0LM41, B3KMN4, D6RGD8, O75932, Q2PYN1, Q53GV1, Q68DQ9, Q96PK5, Q96PK6

UniProtKB/TrEMBL

A0A0S2Z4Z0

Related

ENSP00000311747.5, ENST00000310137.5

Conserved Domains (4) summary

TIGR01628
Location:3 → 280

PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family

PRK13875
Location:319 → 433

PRK13875; conjugal transfer protein TrbL; Provisional

cd12608
Location:1 → 71

RRM1_CoAA; RNA recognition motif 1 in vertebrate RRM-containing coactivator activator/modulator (CoAA)

cd12609
Location:79 → 146

RRM2_CoAA; RNA recognition motif 2 in vertebrate RRM-containing coactivator activator/modulator (CoAA)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000011.10 Reference GRCh38.p14 Primary Assembly

Range

66616630..66629934

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GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

NC_060935.1 Alternate T2T-CHM13v2.0

Range

66612875..66626179

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GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_032886.2: Suppressed sequence

Description

NM_032886.2: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.