U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    LINC00324 long intergenic non-protein coding RNA 324 [ Homo sapiens (human) ]

    Gene ID: 284029, updated on 31-Mar-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    LINC00324provided by HGNC
    Official Full Name
    long intergenic non-protein coding RNA 324provided by HGNC
    Primary source
    HGNC:HGNC:26628
    See related
    Ensembl:ENSG00000178977 AllianceGenome:HGNC:26628
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C17orf44; RNA00324; TP53LC03; NCRNA00324
    Expression
    Ubiquitous expression in lymph node (RPKM 2.5), spleen (RPKM 2.2) and 24 other tissues See more
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    17p13.1
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (8220630..8224043, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (8126855..8130271, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (8123948..8127361, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124903913 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11682 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11683 Neighboring gene nonconserved acetylation island sequence 72 enhancer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:8107017-8107517 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:8113125-8113784 Neighboring gene aurora kinase B Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr17:8124016-8124902 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11686 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8176 Neighboring gene tRNA-Trp (anticodon CCA) 1-1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11687 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8177 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:8126237-8126978 Neighboring gene tRNA-Gly (anticodon TCC) 3-1 Neighboring gene tRNA-Asp (anticodon GTC) 2-11 Neighboring gene tRNA-Pro (anticodon CGG) 1-3 Neighboring gene tRNA-Thr (anticodon AGT) 1-2 Neighboring gene tRNA-Ser (anticodon AGA) 2-6 Neighboring gene CST telomere replication complex component 1

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. A concise review on the role of LINC00324 in different cancers. Ghafouri-Fard S, et al. Pathol Res Pract, 2022 Dec. PMID 36399929
    2. Suppression of long noncoding RNA LINC00324 restricts cell proliferation and invasion of papillary thyroid carcinoma through downregulation of TRIM29 via upregulating microRNA-195-5p. Xu J, et al. Aging (Albany NY), 2020 Dec 14. PMID 33318312, Free PMC Article
    3. Linc00324 promotes the progression of papillary thyroid cancer via regulating Notch signaling pathway. Wan JF, et al. Eur Rev Med Pharmacol Sci, 2020 Jun. PMID 32633374
    4. Long intergenic non-protein coding RNA 324 prevents breast cancer progression by modulating miR-10b-5p. Wang B, et al. Aging (Albany NY), 2020 Apr 18. PMID 32305959, Free PMC Article
    5. [Correlation analysis between LINC00324 and immunophenotype in peripheral blood leukocytes in patients with acute myeloid leukemia]. Liu Y, et al. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, 2019 Sep. PMID 31750827

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Dysregulation of LINC00324 promotes poor prognosis in patients with glioma.
      Title: Dysregulation of LINC00324 promotes poor prognosis in patients with glioma.
    2. Effect of lncRNA LINC00324 on cervical cancer progression through down-regulation of miR-195-5p.
      Title: Effect of lncRNA LINC00324 on cervical cancer progression through down-regulation of miR-195-5p.
    3. A p53/LINC00324 positive feedback loop suppresses tumor growth by counteracting SET-mediated transcriptional repression.
      Title: A p53/LINC00324 positive feedback loop suppresses tumor growth by counteracting SET-mediated transcriptional repression.
    4. LINC00324 promotes cell proliferation and metastasis of esophageal squamous cell carcinoma through sponging miR-493-5p via MAPK signaling pathway.
      Title: LINC00324 promotes cell proliferation and metastasis of esophageal squamous cell carcinoma through sponging miR-493-5p via MAPK signaling pathway.
    5. LINC00324 suppresses apoptosis and autophagy in nasopharyngeal carcinoma through upregulation of PAD4 and activation of the PI3K/AKT signaling pathway.
      Title: LINC00324 suppresses apoptosis and autophagy in nasopharyngeal carcinoma through upregulation of PAD4 and activation of the PI3K/AKT signaling pathway.
    6. A concise review on the role of LINC00324 in different cancers.
      Title: A concise review on the role of LINC00324 in different cancers.
    7. LncRNA LINC00324 is upregulated in intervertebral disk degeneration and upregulates FasL in nucleus pulposus cells.
      Title: LncRNA LINC00324 is upregulated in intervertebral disk degeneration and upregulates FasL in nucleus pulposus cells.
    8. LINC00324 facilitates cell proliferation through competing for miR2145p in immature ovarian teratocarcinoma.
      Title: LINC00324 facilitates cell proliferation through competing for miR‑214‑5p in immature ovarian teratocarcinoma.
    9. Suppression of long noncoding RNA LINC00324 restricts cell proliferation and invasion of papillary thyroid carcinoma through downregulation of TRIM29 via upregulating microRNA-195-5p.
      Title: Suppression of long noncoding RNA LINC00324 restricts cell proliferation and invasion of papillary thyroid carcinoma through downregulation of TRIM29 via upregulating microRNA-195-5p.
    10. Linc00324 promotes the progression of papillary thyroid cancer via regulating Notch signaling pathway.
      Title: Linc00324 promotes the progression of papillary thyroid cancer via regulating Notch signaling pathway.
    Submit: New GeneRIF Correction See all GeneRIFs (17)

    Phenotypes

    Go to the top of the page Help

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

    Go to the top of the page Help

    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Clone Names

    • FLJ34790, MGC104931

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_026951.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC135178, AK092109, BC089396
      Related
      ENST00000315707.4

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      8220630..8224043 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      8126855..8130271 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_173621.1: Suppressed sequence

      Description
      NM_173621.1: This RefSeq was permanently suppressed because currently there is support for the transcript, but not for the protein, and it is a candidate for nonsense-mediated decay.
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Miscellaneous