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    SCTR secretin receptor [ Homo sapiens (human) ]

    Gene ID: 6344, updated on 11-Apr-2024

    Summary

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    Official Symbol
    SCTRprovided by HGNC
    Official Full Name
    secretin receptorprovided by HGNC
    Primary source
    HGNC:HGNC:10608
    See related
    Ensembl:ENSG00000080293 MIM:182098; AllianceGenome:HGNC:10608
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SR
    Summary
    The protein encoded by this gene is a G protein-coupled receptor and belongs to the glucagon-VIP-secretin receptor family. It binds secretin which is the most potent regulator of pancreatic bicarbonate, electrolyte and volume secretion. Secretin and its receptor are suggested to be involved in pancreatic cancer and autism. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in duodenum (RPKM 6.3), pancreas (RPKM 4.3) and 5 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    2q14.2
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (119439843..119524483, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (119873301..119957984, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (120197419..120282059, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene chromosome 2 open reading frame 76 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16450 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16451 Neighboring gene diazepam binding inhibitor, acyl-CoA binding protein Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11905 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:120189865-120190371 Neighboring gene transmembrane protein 37 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:120231245-120231796 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:120232347-120232897 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:120238515-120239026 Neighboring gene VISTA enhancer hs1941 Neighboring gene SCTR antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11906 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16452 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11907 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11908 Neighboring gene cilia and flagella associated protein 221 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11909 Neighboring gene MPRA-validated peak3833 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11910 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11911 Neighboring gene transmembrane protein 177 Neighboring gene ribosomal protein L17 pseudogene 15

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Structure of the human secretin receptor coupled to an engineered heterotrimeric G protein. Fukuhara S, et al. Biochem Biophys Res Commun, 2020 Dec 17. PMID 33008599
    2. SCTR hypermethylation is a diagnostic biomarker in colorectal cancer. Li D, et al. Cancer Sci, 2020 Dec. PMID 32970347, Free PMC Article
    3. Structure and dynamics of the active Gs-coupled human secretin receptor. Dong M, et al. Nat Commun, 2020 Aug 18. PMID 32811827, Free PMC Article
    4. Use of Cysteine Trapping to Map Spatial Approximations between Residues Contributing to the Helix N-capping Motif of Secretin and Distinct Residues within Each of the Extracellular Loops of Its Receptor. Dong M, et al. J Biol Chem, 2016 Mar 4. PMID 26740626, Free PMC Article
    5. SCTR regulates cell cycle-related genes toward anti-proliferation in normal breast cells while having pro-proliferation activity in breast cancer cells. Kang S, et al. Int J Oncol, 2015 Nov. PMID 26397240

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Expression of Secretin and its Receptor Along the Intestinal Tract in Type 2 Diabetes Patients and Healthy Controls.
      Title: Expression of Secretin and its Receptor Along the Intestinal Tract in Type 2 Diabetes Patients and Healthy Controls.
    2. Inhibition of Secretin/Secretin Receptor Axis Ameliorates NAFLD Phenotypes.
      Title: Inhibition of Secretin/Secretin Receptor Axis Ameliorates NAFLD Phenotypes.
    3. Structure of the human secretin receptor coupled to an engineered heterotrimeric G protein.
      Title: Structure of the human secretin receptor coupled to an engineered heterotrimeric G protein.
    4. SCTR hypermethylation is a diagnostic biomarker in colorectal cancer.
      Title: SCTR hypermethylation is a diagnostic biomarker in colorectal cancer.
    5. Structure and dynamics of the active Gs-coupled human secretin receptor.
      Title: Structure and dynamics of the active Gs-coupled human secretin receptor.
    6. High secretin/secretin receptor signaling mediates biliary damage and liver fibrosis in early-stage primary biliary cholangitis.
      Title: Secretin/secretin receptor signaling mediates biliary damage and liver fibrosis in early-stage primary biliary cholangitis.
    7. elevated in primary sclerosing cholangitis liver samples compared to healthy controls
      Title: The secretin/secretin receptor axis modulates liver fibrosis through changes in transforming growth factor-β1 biliary secretion in mice.
    8. Structure and Function of Cross-class Complexes of G Protein-coupled Secretin and Angiotensin 1a Receptors.
      Title: Structure and Function of Cross-class Complexes of G Protein-coupled Secretin and Angiotensin 1a Receptors.
    9. Cysteine trapping identified charge-charge interactions between secretin and secretin receptor residues in TM5, TM6, ECL2, and ECL3 domains.
      Title: Use of Cysteine Trapping to Map Spatial Approximations between Residues Contributing to the Helix N-capping Motif of Secretin and Distinct Residues within Each of the Extracellular Loops of Its Receptor.
    10. Our findings indicate that SCTR suppresses the proliferation of normal breast cells, while the gene stimulates the proliferation and migration of cancer cells being downregulated by promoter methylation.
      Title: SCTR regulates cell cycle-related genes toward anti-proliferation in normal breast cells while having pro-proliferation activity in breast cancer cells.
    Submit: New GeneRIF Correction See all GeneRIFs (27)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled peptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptide hormone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptide hormone binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables secretin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables secretin receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in diet induced thermogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in intracellular water homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of appetite ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of synaptic plasticity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in response to nutrient levels ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasmic microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    secretin receptor
    Names
    pancreatic secretin receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029904.1 RefSeqGene

      Range
      4970..89610
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_002980.3 → NP_002971.2  secretin receptor precursor

      See identical proteins and their annotated locations for NP_002971.2

      Status: REVIEWED

      Source sequence(s)
      AC013275
      Consensus CDS
      CCDS2127.1
      UniProtKB/Swiss-Prot
      P47872, Q12961, Q13213, Q53T00
      UniProtKB/TrEMBL
      B2RBF3, Q8IV17
      Related
      ENSP00000019103.6, ENST00000019103.8
      Conserved Domains (2) summary
      pfam00002
      Location:139 → 384
      7tm_2; 7 transmembrane receptor (Secretin family)
      pfam02793
      Location:64 → 126
      HRM; Hormone receptor domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      119439843..119524483 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011511621.3 → XP_011509923.1  secretin receptor isoform X3

      UniProtKB/TrEMBL
      B2RBF3, Q8IV17
      Conserved Domains (2) summary
      pfam00002
      Location:139 → 389
      7tm_2; 7 transmembrane receptor (Secretin family)
      pfam02793
      Location:64 → 126
      HRM; Hormone receptor domain

    2. XM_047445401.1 → XP_047301357.1  secretin receptor isoform X5

    3. XM_047445400.1 → XP_047301356.1  secretin receptor isoform X2

    4. XM_047445399.1 → XP_047301355.1  secretin receptor isoform X1

    5. XM_017004670.2 → XP_016860159.2  secretin receptor isoform X4

    6. XM_047445403.1 → XP_047301359.1  secretin receptor isoform X7

    7. XM_047445402.1 → XP_047301358.1  secretin receptor isoform X6

    8. XM_047445404.1 → XP_047301360.1  secretin receptor isoform X8

    RNA

    1. XR_922984.3 RNA Sequence

    2. XR_001738889.2 RNA Sequence

    3. XR_007079571.1 RNA Sequence

    4. XR_001738888.2 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      119873301..119957984 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054343329.1 → XP_054199304.1  secretin receptor isoform X3

    2. XM_054343331.1 → XP_054199306.1  secretin receptor isoform X5

    3. XM_054343328.1 → XP_054199303.1  secretin receptor isoform X2

    4. XM_054343327.1 → XP_054199302.1  secretin receptor isoform X1

    5. XM_054343330.1 → XP_054199305.1  secretin receptor isoform X4

    6. XM_054343333.1 → XP_054199308.1  secretin receptor isoform X7

    7. XM_054343332.1 → XP_054199307.1  secretin receptor isoform X6

    8. XM_054343334.1 → XP_054199309.1  secretin receptor isoform X8

    RNA

    1. XR_008486482.1 RNA Sequence

    2. XR_008486484.1 RNA Sequence

    3. XR_008486481.1 RNA Sequence

    4. XR_008486483.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P47872.2 GenPept UniProtKB/Swiss-Prot:P47872

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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