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    LINC00515 long intergenic non-protein coding RNA 515 [ Homo sapiens (human) ]

    Gene ID: 282566, updated on 10-Oct-2023

    Summary

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    Official Symbol
    LINC00515provided by HGNC
    Official Full Name
    long intergenic non-protein coding RNA 515provided by HGNC
    Primary source
    HGNC:HGNC:16019
    See related
    Ensembl:ENSG00000260583 AllianceGenome:HGNC:16019
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PRED21; C21orf71
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    Genomic context

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    Location:
    21q21.3
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 21 NC_000021.9 (25582775..25583224, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 21 NC_060945.1 (23940339..23940788, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (26955087..26955536, complement)

    Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372753 Neighboring gene uncharacterized LOC124905059 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18306 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:26890717-26891218 Neighboring gene ReSE screen-validated silencer GRCh37_chr21:26903379-26903482 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18307 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18308 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13225 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13226 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18309 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13227 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13228 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13229 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18310 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18311 Neighboring gene MIR155 host gene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18312 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18313 Neighboring gene microRNA 155 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18314 Neighboring gene mitochondrial ribosomal protein L39 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13230 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18315 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13231 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:27012080-27012580 Neighboring gene uncharacterized LOC124905001 Neighboring gene RNA guanylyltransferase and 5'-phosphatase pseudogene 1 Neighboring gene junctional adhesion molecule 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Downregulation of LINC00515 in high-grade serous ovarian cancer and its relationship with platinum resistance. Ni MW, et al. Biomark Med, 2019 May. PMID 31140829
    2. Knockdown of Linc00515 Inhibits Multiple Myeloma Autophagy and Chemoresistance by Upregulating miR-140-5p and Downregulating ATG14. Lu D, et al. Cell Physiol Biochem, 2018. PMID 30121664

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LINC00515 downregulation is correlated with HGSOC development, platinum resistance and RFS
      Title: Downregulation of LINC00515 in high-grade serous ovarian cancer and its relationship with platinum resistance.
    2. Knockdown of linc00515 leds to decreased autophagy and chemoresistance of melphalan-resistant myeloma cells.
      Title: Knockdown of Linc00515 Inhibits Multiple Myeloma Autophagy and Chemoresistance by Upregulating miR-140-5p and Downregulating ATG14.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    General gene information

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    Markers

    Clone Names

    • AP000223.42

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_024092.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AF086441, AP000223
      Related
      ENST00000567517.1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000021.9 Reference GRCh38.p14 Primary Assembly

      Range
      25582775..25583224 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060945.1 Alternate T2T-CHM13v2.0

      Range
      23940339..23940788 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases