CDCA5 cell division cycle associated 5 [Homo sapiens (human)] - Gene

Summary

Official Symbol: CDCA5provided by HGNC
Official Full Name: cell division cycle associated 5provided by HGNC
Primary source: HGNC:HGNC:14626
See related: Ensembl:ENSG00000146670 MIM:609374; AllianceGenome:HGNC:14626
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: SORORIN
Summary: Predicted to enable chromatin binding activity. Involved in double-strand break repair; mitotic sister chromatid segregation; and regulation of cell cycle process. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in bone marrow (RPKM 12.1), testis (RPKM 11.0) and 13 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 11q13.1

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	11	NC_000011.10 (65061093..65084040, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	11	NC_060935.1 (65054375..65077318, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	11	NC_000011.9 (64844925..64851512, complement)

Chromosome 11 - NC_000011.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CDCA5 promoted cell invasion and migration by activating TGF-beta1 pathway in human ovarian cancer cells.
Title: CDCA5 promoted cell invasion and migration by activating TGF-β1 pathway in human ovarian cancer cells.
KLF5-mediated CDCA5 expression promotes tumor development and progression of epithelial ovarian carcinoma.
Title: KLF5-mediated CDCA5 expression promotes tumor development and progression of epithelial ovarian carcinoma.
CDCA5 promotes the progression of breast cancer and serves as a potential prognostic biomarker.
Title: CDCA5 promotes the progression of breast cancer and serves as a potential prognostic biomarker.
Loss of cell division cycleassociated 5 promotes cell apoptosis by activating DNA damage response in clear cell renal cell carcinoma.
Title: Loss of cell division cycle‑associated 5 promotes cell apoptosis by activating DNA damage response in clear cell renal cell carcinoma.
Knockdown of CDCA5 suppresses malignant progression of breast cancer cells by regulating PDS5A.
Title: Knockdown of CDCA5 suppresses malignant progression of breast cancer cells by regulating PDS5A.
Silencing oncogene cell division cycle associated 5 induces apoptosis and G1 phase arrest of non-small cell lung cancer cells via p53-p21 signaling pathway.
Title: Silencing oncogene cell division cycle associated 5 induces apoptosis and G1 phase arrest of non-small cell lung cancer cells via p53-p21 signaling pathway.
TPI1 activates the PI3K/AKT/mTOR signaling pathway to induce breast cancer progression by stabilizing CDCA5.
Title: TPI1 activates the PI3K/AKT/mTOR signaling pathway to induce breast cancer progression by stabilizing CDCA5.
CDCA5 is negatively regulated by miR-326 and boosts ovarian cancer progression.
Title: CDCA5 is negatively regulated by miR-326 and boosts ovarian cancer progression.
LINC01515 promotes nasopharyngeal carcinoma progression by serving as a sponge for miR-325 to up-regulate CDCA5.
Title: LINC01515 promotes nasopharyngeal carcinoma progression by serving as a sponge for miR-325 to up-regulate CDCA5.
Downregulation of CDCA5 Can Inhibit Cell Proliferation, Migration, and Invasion, and Induce Apoptosis of Prostate Cancer Cells.
Title: Downregulation of CDCA5 Can Inhibit Cell Proliferation, Migration, and Invasion, and Induce Apoptosis of Prostate Cancer Cells.

Submit: New GeneRIF Correction See all GeneRIFs (35)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

WI-21617 (e-PCR)
- UniSTS:52643

A002B21 (e-PCR)
- UniSTS:6068

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables chromatin binding	TAS Traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in double-strand break repair	IBA Inferred from Biological aspect of Ancestor more info
involved_in double-strand break repair	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic cell cycle	IDA Inferred from Direct Assay more info	PubMed
involved_in mitotic chromosome condensation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic metaphase chromosome alignment	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic metaphase chromosome alignment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic sister chromatid cohesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic sister chromatid cohesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic sister chromatid cohesion	IPI Inferred from Physical Interaction more info	PubMed
involved_in positive regulation of exit from mitosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of exit from mitosis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of chromatin	ISS Inferred from Sequence or Structural Similarity more info
located_in chromosome	TAS Traceable Author Statement more info
located_in chromosome, centromeric region	TAS Traceable Author Statement more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	TAS Traceable Author Statement more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: sororin

Names: cell division cycle-associated protein 5; p35

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_080668.4 → NP_542399.1 sororin

See identical proteins and their annotated locations for NP_542399.1

Status: VALIDATED

Source sequence(s)

AP003068, BC011000

Consensus CDS

CCDS8091.1

UniProtKB/Swiss-Prot

A8K625, Q96FF9

UniProtKB/TrEMBL

B5MBX0

Related

ENSP00000275517.3, ENST00000275517.8

Conserved Domains (1) summary

pfam09666
Location:89 → 209

Sororin; Sororin protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000011.10 Reference GRCh38.p14 Primary Assembly

Range

65061093..65084040 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011544743.4 → XP_011543045.1 sororin isoform X3

Conserved Domains (1) summary

pfam09666
Location:89 → 209

Sororin; Sororin protein
XM_017017158.3 → XP_016872647.1 sororin isoform X4
XM_011544747.4 → XP_011543049.1 sororin isoform X5
XM_005273734.5 → XP_005273791.1 sororin isoform X2

Conserved Domains (1) summary

pfam09666
Location:89 → 209

Sororin; Sororin protein
XM_005273733.5 → XP_005273790.1 sororin isoform X1

Conserved Domains (1) summary

pfam09666
Location:89 → 209

Sororin; Sororin protein
XM_011544749.4 → XP_011543051.1 sororin isoform X7

Conserved Domains (1) summary

pfam09666
Location:89 → 209

Sororin; Sororin protein
XM_011544748.4 → XP_011543050.1 sororin isoform X6

Conserved Domains (1) summary

pfam09666
Location:89 → 209

Sororin; Sororin protein