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    TRIM44 tripartite motif containing 44 [ Homo sapiens (human) ]

    Gene ID: 54765, updated on 5-Mar-2024

    Summary

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    Official Symbol
    TRIM44provided by HGNC
    Official Full Name
    tripartite motif containing 44provided by HGNC
    Primary source
    HGNC:HGNC:19016
    See related
    Ensembl:ENSG00000166326 MIM:612298; AllianceGenome:HGNC:19016
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AN3; MC7; DIPB; HSA249128
    Summary
    This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, namely a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in brain (RPKM 26.6), thyroid (RPKM 23.0) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    11p13
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (35662775..35818007)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (35801539..35956748)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (35684323..35839557)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene peptidase domain containing associated with muscle regeneration 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3258 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4624 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3259 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:35639867-35640028 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3261 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:35640328-35640962 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:35640963-35641597 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr11:35650952-35652151 Neighboring gene NANOG hESC enhancer GRCh37_chr11:35676186-35676747 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4625 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:35684511-35685011 Neighboring gene four-jointed box kinase 1 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_21277 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4626 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4627 Neighboring gene OCT4 hESC enhancer GRCh37_chr11:35774016-35774517 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_21295 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:35793100-35793607 Neighboring gene uncharacterized LOC124902661 Neighboring gene keratin 18 pseudogene 14

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Clinical Significance of TRIM44 Expression in Patients with Gastric Cancer. Goshayeshi L, et al. Asian Pac J Cancer Prev, 2022 May 1. PMID 35633558, Free PMC Article
    2. TRIM44 facilitates ovarian cancer proliferation, migration, and invasion by inhibiting FRK. Yu XZ, et al. Neoplasma, 2021 Jul. PMID 34034495
    3. Expression of tripartite motif-containing 44 and its prognostic and clinicopathological value in human malignancies:a meta-analysis. Xiao G, et al. BMC Cancer, 2020 Jun 5. PMID 32503466, Free PMC Article
    4. TRIM44 is indispensable for glioma cell proliferation and cell cycle progression through AKT/p21/p27 signaling pathway. Zhou X, et al. J Neurooncol, 2019 Nov. PMID 31605296
    5. High TRIM44 expression as a valuable biomarker for diagnosis and prognosis in cervical cancer. Liu S, et al. Biosci Rep, 2019 Mar 29. PMID 30792262, Free PMC Article

    See all (65) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Silencing LINC00491 inhibits prostate cancer development through the miR-384/TRIM44 axis.
      Title: Silencing LINC00491 inhibits prostate cancer development through the miR-384/TRIM44 axis.
    2. TRIM44 regulates tumor immunity in gastric cancer through LOXL2-dependent extracellular matrix remodeling.
      Title: TRIM44 regulates tumor immunity in gastric cancer through LOXL2-dependent extracellular matrix remodeling.
    3. Long noncoding RNA LINC00858 promotes the progression of ovarian cancer via regulating the miR-134-5p/TRIM44 axis.
      Title: Long noncoding RNA LINC00858 promotes the progression of ovarian cancer via regulating the miR-134-5p/TRIM44 axis.
    4. CircFBXW8 Acts an Oncogenic Role in the Malignant Progression of Non-small Cell Lung Carcinoma by miR-370-3p-Dependent Regulation of TRIM44.
      Title: CircFBXW8 Acts an Oncogenic Role in the Malignant Progression of Non-small Cell Lung Carcinoma by miR-370-3p-Dependent Regulation of TRIM44.
    5. Clinical Significance of TRIM44 Expression in Patients with Gastric Cancer.
      Title: Clinical Significance of TRIM44 Expression in Patients with Gastric Cancer.
    6. TRIM44 promotes BRCA1 functions in HR repair to induce Cisplatin Chemoresistance in Lung Adenocarcinoma by Deubiquitinating FLNA.
      Title: TRIM44 promotes BRCA1 functions in HR repair to induce Cisplatin Chemoresistance in Lung Adenocarcinoma by Deubiquitinating FLNA.
    7. YTHDF1 promotes the proliferation, migration, and invasion of prostate cancer cells by regulating TRIM44.
      Title: YTHDF1 promotes the proliferation, migration, and invasion of prostate cancer cells by regulating TRIM44.
    8. Knockdown of circRAD23B Exerts Antitumor Response in Colorectal Cancer via the Regulation of miR-1205/TRIM44 axis.
      Title: Knockdown of circRAD23B Exerts Antitumor Response in Colorectal Cancer via the Regulation of miR-1205/TRIM44 axis.
    9. TRIM44 mediated p62 deubiquitination enhances DNA damage repair by increasing nuclear FLNA and 53BP1 expression.
      Title: TRIM44 mediated p62 deubiquitination enhances DNA damage repair by increasing nuclear FLNA and 53BP1 expression.
    10. MiR-34a-5p directly targeting TRIM44 affects the biological behavior of ovarian cancer cells.
      Title: MiR-34a-5p directly targeting TRIM44 affects the biological behavior of ovarian cancer cells.
    Submit: New GeneRIF Correction See all GeneRIFs (40)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Aniridia 3
    MedGen: C4310695 OMIM: 617142 GeneReviews: Not available
    		Compare labs

    EBI GWAS Catalog

    Description
    Genomewide association study of movement-related adverse antipsychotic effects.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of tripartite motif containing 44 (TRIM44) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC3490

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of protein K48-linked ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of cytokine-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of defense response to virus by host IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of non-canonical NF-kappaB signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein stabilization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein stabilization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to angiotensin IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    tripartite motif-containing protein 44

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_052784.1 RefSeqGene

      Range
      5061..153362
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_017583.6 → NP_060053.2  tripartite motif-containing protein 44

      See identical proteins and their annotated locations for NP_060053.2

      Status: REVIEWED

      Source sequence(s)
      AC090692, AK074242, BI222592, BI550863, BQ014398, CA445350, CX788887, CX871447, DA128342, DA131915, DA158251
      Consensus CDS
      CCDS31461.1
      UniProtKB/Swiss-Prot
      D3DR14, Q96DX7, Q96QY2, Q9UGK0
      Related
      ENSP00000299413.5, ENST00000299413.7
      Conserved Domains (2) summary
      cd19784
      Location:177 → 215
      Bbox2_TRIM44; B-box-type 2 zinc finger found in tripartite motif-containing protein 44 (TRIM44) and similar proteins
      cd19841
      Location:15 → 60
      Bbox1_TRIM44; B-box-type 1 zinc finger found in tripartite motif-containing protein 44 (TRIM44) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      35662775..35818007
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006718254.2 → XP_006718317.1  tripartite motif-containing protein 44 isoform X1

      Conserved Domains (1) summary
      pfam00643
      Location:177 → 215
      zf-B_box; B-box zinc finger

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      35801539..35956748
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054369171.1 → XP_054225146.1  tripartite motif-containing protein 44 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96DX7.1 GenPept UniProtKB/Swiss-Prot:Q96DX7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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