GPAT3 glycerol-3-phosphate acyltransferase 3 [Homo sapiens (human)] - Gene

Summary

Official Symbol: GPAT3provided by HGNC
Official Full Name: glycerol-3-phosphate acyltransferase 3provided by HGNC
Primary source: HGNC:HGNC:28157
See related: Ensembl:ENSG00000138678 MIM:610958; AllianceGenome:HGNC:28157
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MAG1; AGPAT8; AGPAT9; AGPAT10; AGPAT 10; HMFN0839; LPAAT-theta
Summary: This gene encodes a member of the lysophosphatidic acid acyltransferase protein family. The encoded protein is an enzyme which catalyzes the conversion of glycerol-3-phosphate to lysophosphatidic acid in the synthesis of triacylglycerol. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2012]
Expression: Broad expression in kidney (RPKM 23.1), duodenum (RPKM 10.2) and 14 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 4q21.23

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	4	NC_000004.12 (83535587..83605875)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	4	NC_060928.1 (86865686..86935953)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	4	NC_000004.11 (84457067..84527028)

Chromosome 4 - NC_000004.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GPAT3 regulates the synthesis of lipid intermediate LPA and exacerbates Kupffer cell inflammation mediated by the ERK signaling pathway.
Title: GPAT3 regulates the synthesis of lipid intermediate LPA and exacerbates Kupffer cell inflammation mediated by the ERK signaling pathway.
Oligomers of the lipodystrophy protein seipin may co-ordinate GPAT3 and AGPAT2 enzymes to facilitate adipocyte differentiation.
Title: Oligomers of the lipodystrophy protein seipin may co-ordinate GPAT3 and AGPAT2 enzymes to facilitate adipocyte differentiation.
Data show that 1-acylglycerol-3-phosphate O-acyltransferase 9 (AGPAT9) inhibit cell growth by regulating expression of KLF4/LASS2/V-ATPase proteins in breast cancer.
Title: AGPAT9 suppresses cell growth, invasion and metastasis by counteracting acidic tumor microenvironment through KLF4/LASS2/V-ATPase signaling pathway in breast cancer.
findings identified a direct role that mag-1 played in metastasis and implicated its function in cellular adaptation to tumour microenvironment
Title: Metastasis-associated gene, mag-1 improves tumour microenvironmental adaptation and potentiates tumour metastasis.
Results reveal a link between the lipogenic effects of insulin and microsomal GPAT3 and GPAT4, implying their importance in glycerolipid biosynthesis.
Title: GPAT3 and GPAT4 are regulated by insulin-stimulated phosphorylation and play distinct roles in adipogenesis.
LPAAT-theta gene consisted of 12 exons and 11 introns, and mapped to chromosome 4q21.23, was ubiquitously expressed in 18 human tissues and overexpression of LPAAT-theta can induce mTOR-dependent p70S6K and 4EBP1 phosphorylation in HEK293T cells.
Title: Identification of a novel human lysophosphatidic acid acyltransferase, LPAAT-theta, which activates mTOR pathway.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables 1-acylglycerol-3-phosphate O-acyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables 1-acylglycerol-3-phosphate O-acyltransferase activity	TAS Traceable Author Statement more info
NOT enables glycerol-3-phosphate O-acyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables glycerol-3-phosphate O-acyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables sn-1-glycerol-3-phosphate C16:0-DCA-CoA acyl transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in CDP-diacylglycerol biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in glycerol-3-phosphate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in phosphatidic acid biosynthetic process	TAS Traceable Author Statement more info
involved_in regulation of TOR signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in triglyceride biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in triglyceride biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: glycerol-3-phosphate acyltransferase 3

Names: 1-AGP acyltransferase 9; 1-AGPAT 9; 1-acyl-sn-glycerol-3-phosphate O-acyltransferase 10; 1-acyl-sn-glycerol-3-phosphate O-acyltransferase 9; 1-acylglycerol-3-phosphate O-acyltransferase 8; 1-acylglycerol-3-phosphate O-acyltransferase 9; GPAT-3; MAG-1; acyl-CoA:glycerol-3-phosphate acyltransferase 3; endoplasmic reticulum associated GPAT; hGPAT3; lung cancer metastasis-associated protein 1; lysophosphatidic acid acyltransferase theta; testis secretory sperm-binding protein Li 213e

NP_001243350.1

EC 2.3.1.15

EC 2.3.1.51

NP_001243351.1

EC 2.3.1.15

EC 2.3.1.51

NP_116106.2

EC 2.3.1.15

EC 2.3.1.51

XP_011530686.1

EC 2.3.1.15

EC 2.3.1.51

XP_016864269.1

EC 2.3.1.15

EC 2.3.1.51

XP_016864270.1

EC 2.3.1.15

EC 2.3.1.51

XP_054207093.1

EC 2.3.1.15

EC 2.3.1.51

XP_054207094.1

EC 2.3.1.15

EC 2.3.1.51

XP_054207095.1

EC 2.3.1.15

EC 2.3.1.51

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001256421.1 → NP_001243350.1 glycerol-3-phosphate acyltransferase 3

See identical proteins and their annotated locations for NP_001243350.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.

Source sequence(s)

AC021192, AC096768, AK055749, BM841009

Consensus CDS

CCDS3606.1

UniProtKB/Swiss-Prot

Q53EU6, Q68CJ4, Q6GPI6, Q96NA3

UniProtKB/TrEMBL

A0A024RDG5, A0A140VK86

Related

ENSP00000378651.2, ENST00000395226.6

Conserved Domains (1) summary

cd07991
Location:199 → 408

LPLAT_LPCAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like
NM_001256422.1 → NP_001243351.1 glycerol-3-phosphate acyltransferase 3

See identical proteins and their annotated locations for NP_001243351.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.

Source sequence(s)

AC021192, BM841009, DA393801

Consensus CDS

CCDS3606.1

UniProtKB/Swiss-Prot

Q53EU6, Q68CJ4, Q6GPI6, Q96NA3

UniProtKB/TrEMBL

A0A024RDG5, A0A140VK86

Related

ENSP00000482571.1, ENST00000611707.4

Conserved Domains (1) summary

cd07991
Location:199 → 408

LPLAT_LPCAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like
NM_032717.5 → NP_116106.2 glycerol-3-phosphate acyltransferase 3

See identical proteins and their annotated locations for NP_116106.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.

Source sequence(s)

AC096768, AY358100, BM841009, DA673378

Consensus CDS

CCDS3606.1

UniProtKB/Swiss-Prot

Q53EU6, Q68CJ4, Q6GPI6, Q96NA3

UniProtKB/TrEMBL

A0A024RDG5, A0A140VK86

Related

ENSP00000264409.4, ENST00000264409.5

Conserved Domains (1) summary

cd07991
Location:199 → 408

LPLAT_LPCAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000004.12 Reference GRCh38.p14 Primary Assembly

Range

83535587..83605875

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017008780.2 → XP_016864269.1 glycerol-3-phosphate acyltransferase 3 isoform X1
XM_017008781.2 → XP_016864270.1 glycerol-3-phosphate acyltransferase 3 isoform X2

UniProtKB/Swiss-Prot

Q53EU6, Q68CJ4, Q6GPI6, Q96NA3

UniProtKB/TrEMBL

A0A024RDG5, A0A140VK86

Conserved Domains (1) summary

cd07991
Location:199 → 408

LPLAT_LPCAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like
XM_011532384.3 → XP_011530686.1 glycerol-3-phosphate acyltransferase 3 isoform X3

See identical proteins and their annotated locations for XP_011530686.1

Conserved Domains (1) summary

cd07991
Location:121 → 330

LPLAT_LPCAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like

Alternate T2T-CHM13v2.0

Genomic

NC_060928.1 Alternate T2T-CHM13v2.0

Range

86865686..86935953

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054351118.1 → XP_054207093.1 glycerol-3-phosphate acyltransferase 3 isoform X1
XM_054351119.1 → XP_054207094.1 glycerol-3-phosphate acyltransferase 3 isoform X2

UniProtKB/Swiss-Prot

Q53EU6, Q68CJ4, Q6GPI6, Q96NA3

UniProtKB/TrEMBL

A0A024RDG5, A0A140VK86
XM_054351120.1 → XP_054207095.1 glycerol-3-phosphate acyltransferase 3 isoform X3