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    ATE1 arginyltransferase 1 [ Homo sapiens (human) ]

    Gene ID: 11101, updated on 7-Apr-2024

    Summary

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    Official Symbol
    ATE1provided by HGNC
    Official Full Name
    arginyltransferase 1provided by HGNC
    Primary source
    HGNC:HGNC:782
    See related
    Ensembl:ENSG00000107669 MIM:607103; AllianceGenome:HGNC:782
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene encodes an arginyltransferase, an enzyme that is involved in posttranslational conjugation of arginine to N-terminal aspartate or glutamate residues. Conjugation of arginine to the N-terminal aspartate or glutamate targets proteins for ubiquitin-dependent degradation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
    Expression
    Ubiquitous expression in thyroid (RPKM 8.9), testis (RPKM 7.9) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    10q26.13
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (121740424..121928463, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (122636555..122824802, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (123499939..123687978, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:123383269-123383770 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:123383771-123384270 Neighboring gene uncharacterized LOC107984183 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:123403785-123404286 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:123427853-123428402 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:123428403-123428952 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:123441905-123442847 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:123455553-123456052 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:123455051-123455552 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr10:123492224-123492816 Neighboring gene ribosomal protein S15a pseudogene 5 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4140 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4141 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:123687446-123688312 Neighboring gene Sharpr-MPRA regulatory region 2750 Neighboring gene ATE1 antisense RNA 1 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr10:123734371-123735166 Neighboring gene uncharacterized LOC124902517 Neighboring gene NSE4 homolog A, SMC5-SMC6 complex component Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr10:123778189-123779388 Neighboring gene transforming acidic coiled-coil containing protein 2 Neighboring gene Sharpr-MPRA regulatory region 10515 Neighboring gene Sharpr-MPRA regulatory regions 8460 and 2354 Neighboring gene MPRA-validated peak1120 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:123836619-123837120 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:123844981-123845482 Neighboring gene Sharpr-MPRA regulatory regions 1076 and 11287 Neighboring gene uncharacterized LOC124902518 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:123914119-123915090

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. ATE1 Inhibits Liver Cancer Progression through RGS5-Mediated Suppression of Wnt/β-Catenin Signaling. Xu C, et al. Mol Cancer Res, 2021 Sep. PMID 34158395, Free PMC Article
    2. Multiple competing RNA structures dynamically control alternative splicing in the human ATE1 gene. Kalinina M, et al. Nucleic Acids Res, 2021 Jan 11. PMID 33330934, Free PMC Article
    3. Arginyl-tRNA-protein transferase 1 contributes to governing optimal stability of the human immunodeficiency virus type 1 core. Kishimoto N, et al. Retrovirology, 2021 Sep 26. PMID 34565409, Free PMC Article
    4. Reduced Arginyltransferase 1 is a driver and a potential prognostic indicator of prostate cancer metastasis. Birnbaum MD, et al. Oncogene, 2019 Feb. PMID 30177837, Free PMC Article
    5. Arginyltransferase suppresses cell tumorigenic potential and inversely correlates with metastases in human cancers. Rai R, et al. Oncogene, 2016 Aug 4. PMID 26686093, Free PMC Article

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ATE1 Inhibits Liver Cancer Progression through RGS5-Mediated Suppression of Wnt/beta-Catenin Signaling.
      Title: ATE1 Inhibits Liver Cancer Progression through RGS5-Mediated Suppression of Wnt/β-Catenin Signaling.
    2. The Final Maturation State of beta-actin Involves N-terminal Acetylation by NAA80, not N-terminal Arginylation by ATE1.
      Title: The Final Maturation State of β-actin Involves N-terminal Acetylation by NAA80, not N-terminal Arginylation by ATE1.
    3. Arginyl-tRNA-protein transferase 1 contributes to governing optimal stability of the human immunodeficiency virus type 1 core.
      Title: Arginyl-tRNA-protein transferase 1 contributes to governing optimal stability of the human immunodeficiency virus type 1 core.
    4. Multiple competing RNA structures dynamically control alternative splicing in the human ATE1 gene.
      Title: Multiple competing RNA structures dynamically control alternative splicing in the human ATE1 gene.
    5. study revealed a novel role of Ate1 in suppressing prostate cancer metastasis, which has a profound significance for establishing metastatic indicators for prostate cancer, and for finding potential treatments to prevent its metastasis.
      Title: Reduced Arginyltransferase 1 is a driver and a potential prognostic indicator of prostate cancer metastasis.
    6. Ate1 is downregulated in several types of human cancer samples at the protein level, and that its transcription level inversely correlates with metastatic progression and patient survival.
      Title: Arginyltransferase suppresses cell tumorigenic potential and inversely correlates with metastases in human cancers.
    7. Data indicate that arginyltransferase 1 (ATE1) function controls Myocardin-related transcription factor A (MRTF-A) activity.
      Title: Inhibition of arginyltransferase 1 induces transcriptional activity of myocardin-related transcription factor A (MRTF-A) and promotes directional migration.
    8. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    9. Observational study of gene-disease association. (HuGE Navigator)
      Title: A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Novel breast cancer susceptibility locus at 9q31.2: results of a genome-wide association study.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC26724

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables arginyl-tRNA--protein transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables arginyl-tRNA--protein transferase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within proteasomal protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein arginylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein arginylation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    arginyl-tRNA--protein transferase 1
    Names
    R-transferase 1
    arginine-tRNA--protein transferase 1
    arginyl-tRNA-protein transferase
    NP_001001976.1
    NP_001275663.1
    NP_001275664.1
    NP_001275665.1
    NP_008972.2
    XP_005269515.1
    XP_005269516.1
    XP_016871086.2
    XP_016871087.1
    XP_016871088.1
    XP_016871090.2
    XP_016871092.2
    XP_047280477.1
    XP_047280478.1
    XP_047280479.1
    XP_047280480.1
    XP_047280481.1
    XP_047280482.1
    XP_047280483.1
    XP_047280484.1
    XP_047280485.1
    XP_047280486.1
    XP_047280487.1
    XP_047280488.1
    XP_047280489.1
    XP_047280490.1
    XP_047280491.1
    XP_047280492.1
    XP_054220606.1
    XP_054220607.1
    XP_054220608.1
    XP_054220609.1
    XP_054220610.1
    XP_054220611.1
    XP_054220612.1
    XP_054220613.1
    XP_054220614.1
    XP_054220615.1
    XP_054220616.1
    XP_054220617.1
    XP_054220618.1
    XP_054220619.1
    XP_054220620.1
    XP_054220621.1
    XP_054220622.1
    XP_054220623.1
    XP_054220624.1
    XP_054220625.1
    XP_054220626.1
    XP_054220627.1
    XP_054220628.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001001976.3 → NP_001001976.1  arginyl-tRNA--protein transferase 1 isoform 1

      See identical proteins and their annotated locations for NP_001001976.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AC025947, AL731542, AL731566
      Consensus CDS
      CCDS31300.1
      UniProtKB/Swiss-Prot
      O95260, O95261, Q5SQQ3, Q8WW04
      UniProtKB/TrEMBL
      A0A8I5KZ28
      Related
      ENSP00000224652.6, ENST00000224652.12
      Conserved Domains (2) summary
      pfam04376
      Location:21 → 92
      ATE_N; Arginine-tRNA-protein transferase, N terminus
      pfam04377
      Location:290 → 431
      ATE_C; Arginine-tRNA-protein transferase, C terminus

    2. NM_001288734.2 → NP_001275663.1  arginyl-tRNA--protein transferase 1 isoform 3

      See identical proteins and their annotated locations for NP_001275663.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in its 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC025947, AL731542, AL731566
      UniProtKB/TrEMBL
      A0A8I5QKV3, B4DK25
      Conserved Domains (1) summary
      pfam04377
      Location:175 → 316
      ATE_C; Arginine-tRNA-protein transferase, C terminus

    3. NM_001288735.2 → NP_001275664.1  arginyl-tRNA--protein transferase 1 isoform 4

      See identical proteins and their annotated locations for NP_001275664.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in its 5' UTR, initiates translation at a downstream start codon, and uses an alternate in-frame exon in the central coding region, compared to variant 1. The encoded isoform (4) has a shorter N-terminus and a unique internal segment, compared to isoform 1.
      Source sequence(s)
      AC025947, AL731542, AL731566
      UniProtKB/TrEMBL
      A0A8I5QKV3, B4E107
      Related
      ENSP00000509714.1, ENST00000693276.1
      Conserved Domains (1) summary
      pfam04377
      Location:198 → 335
      ATE_C; Arginine-tRNA-protein transferase, C terminus

    4. NM_001288736.2 → NP_001275665.1  arginyl-tRNA--protein transferase 1 isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and coding region, and uses an alternate in-frame exon in the central coding region, compared to variant 1. The encoded isoform (5) has a shorter and distinct N-terminus and a unique internal segment, compared to isoform 1.
      Source sequence(s)
      AC025947, AL731542, AL731566
      Consensus CDS
      CCDS73213.1
      UniProtKB/TrEMBL
      B4DR48, F5GXE4
      Related
      ENSP00000440881.1, ENST00000540606.7
      Conserved Domains (2) summary
      pfam04376
      Location:14 → 85
      ATE_N; Arginine-tRNA-protein transferase, N terminus
      pfam04377
      Location:287 → 424
      ATE_C; Arginine-tRNA-protein transferase, C terminus

    5. NM_007041.4 → NP_008972.2  arginyl-tRNA--protein transferase 1 isoform 2

      See identical proteins and their annotated locations for NP_008972.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame exon in the central coding region, compared to variant 1. The encoded isoform (2) is the same length as isoform 1 but has a unique internal segment.
      Source sequence(s)
      AC025947, AL731542, AL731566
      Consensus CDS
      CCDS31299.1
      UniProtKB/TrEMBL
      A0A8I5KNT9
      Related
      ENSP00000358039.3, ENST00000369043.8
      Conserved Domains (2) summary
      pfam04376
      Location:21 → 92
      ATE_N; Arginine-tRNA-protein transferase, N terminus
      pfam04377
      Location:294 → 431
      ATE_C; Arginine-tRNA-protein transferase, C terminus

    RNA

    1. NR_110006.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) uses an alternate 5'-terminal exon and lacks two internal exons, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
      Source sequence(s)
      AC025947, AL731542, AL731566
      Related
      ENST00000692718.1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      121740424..121928463 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047424532.1 → XP_047280488.1  arginyl-tRNA--protein transferase 1 isoform X16

    2. XM_047424530.1 → XP_047280486.1  arginyl-tRNA--protein transferase 1 isoform X13

    3. XM_017015598.3 → XP_016871087.1  arginyl-tRNA--protein transferase 1 isoform X11

      UniProtKB/TrEMBL
      A0A8I5KNV5, A0A8I5KTH0, B4DR48
      Related
      ENSP00000509590.1, ENST00000689571.1

    4. XM_047424523.1 → XP_047280479.1  arginyl-tRNA--protein transferase 1 isoform X6

    5. XM_005269459.4 → XP_005269516.1  arginyl-tRNA--protein transferase 1 isoform X4

      UniProtKB/TrEMBL
      B4DR48
      Conserved Domains (2) summary
      pfam04376
      Location:14 → 85
      ATE_N; Arginine-tRNA-protein transferase, N terminus
      pfam04377
      Location:330 → 467
      ATE_C; Arginine-tRNA-protein transferase, C terminus

    6. XM_017015599.3 → XP_016871088.1  arginyl-tRNA--protein transferase 1 isoform X15

      UniProtKB/TrEMBL
      A0A8I5KNT9, A0A8I5KZ28, F8WAC9
      Related
      ENSP00000358036.4, ENST00000369040.9

    7. XM_047424529.1 → XP_047280485.1  arginyl-tRNA--protein transferase 1 isoform X12

    8. XM_047424522.1 → XP_047280478.1  arginyl-tRNA--protein transferase 1 isoform X5

    9. XM_005269458.4 → XP_005269515.1  arginyl-tRNA--protein transferase 1 isoform X3

      UniProtKB/TrEMBL
      A0A8I5KZ24, A0A8I5KZ28
      Related
      ENSP00000510433.1, ENST00000690355.1
      Conserved Domains (2) summary
      pfam04376
      Location:21 → 92
      ATE_N; Arginine-tRNA-protein transferase, N terminus
      pfam04377
      Location:337 → 474
      ATE_C; Arginine-tRNA-protein transferase, C terminus

    10. XM_047424527.1 → XP_047280483.1  arginyl-tRNA--protein transferase 1 isoform X9

      Related
      ENSP00000510033.1, ENST00000692278.1

    11. XM_047424525.1 → XP_047280481.1  arginyl-tRNA--protein transferase 1 isoform X8

      Related
      ENSP00000509487.1, ENST00000689393.1

    12. XM_017015597.2 → XP_016871086.2  arginyl-tRNA--protein transferase 1 isoform X2

    13. XM_047424521.1 → XP_047280477.1  arginyl-tRNA--protein transferase 1 isoform X1

    14. XM_047424528.1 → XP_047280484.1  arginyl-tRNA--protein transferase 1 isoform X10

    15. XM_047424524.1 → XP_047280480.1  arginyl-tRNA--protein transferase 1 isoform X7

      Related
      ENSP00000508420.1, ENST00000691573.1

    16. XM_047424531.1 → XP_047280487.1  arginyl-tRNA--protein transferase 1 isoform X14

    17. XM_047424526.1 → XP_047280482.1  arginyl-tRNA--protein transferase 1 isoform X9

    18. XM_047424533.1 → XP_047280489.1  arginyl-tRNA--protein transferase 1 isoform X17

    19. XM_017015603.2 → XP_016871092.2  arginyl-tRNA--protein transferase 1 isoform X19

    20. XM_047424536.1 → XP_047280492.1  arginyl-tRNA--protein transferase 1 isoform X22

      Related
      ENSP00000509863.1, ENST00000687251.1

    21. XM_047424534.1 → XP_047280490.1  arginyl-tRNA--protein transferase 1 isoform X20

    22. XM_017015601.3 → XP_016871090.2  arginyl-tRNA--protein transferase 1 isoform X18

    23. XM_047424535.1 → XP_047280491.1  arginyl-tRNA--protein transferase 1 isoform X21

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      122636555..122824802 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054364647.1 → XP_054220622.1  arginyl-tRNA--protein transferase 1 isoform X16

    2. XM_054364644.1 → XP_054220619.1  arginyl-tRNA--protein transferase 1 isoform X13

    3. XM_054364642.1 → XP_054220617.1  arginyl-tRNA--protein transferase 1 isoform X11

      UniProtKB/TrEMBL
      A0A8I5KTH0

    4. XM_054364636.1 → XP_054220611.1  arginyl-tRNA--protein transferase 1 isoform X6

    5. XM_054364634.1 → XP_054220609.1  arginyl-tRNA--protein transferase 1 isoform X4

    6. XM_054364646.1 → XP_054220621.1  arginyl-tRNA--protein transferase 1 isoform X15

      UniProtKB/TrEMBL
      F8WAC9

    7. XM_054364643.1 → XP_054220618.1  arginyl-tRNA--protein transferase 1 isoform X12

    8. XM_054364635.1 → XP_054220610.1  arginyl-tRNA--protein transferase 1 isoform X5

    9. XM_054364633.1 → XP_054220608.1  arginyl-tRNA--protein transferase 1 isoform X3

      UniProtKB/TrEMBL
      A0A8I5KZ24

    10. XM_054364640.1 → XP_054220615.1  arginyl-tRNA--protein transferase 1 isoform X9

    11. XM_054364638.1 → XP_054220613.1  arginyl-tRNA--protein transferase 1 isoform X8

    12. XM_054364632.1 → XP_054220607.1  arginyl-tRNA--protein transferase 1 isoform X2

    13. XM_054364631.1 → XP_054220606.1  arginyl-tRNA--protein transferase 1 isoform X1

    14. XM_054364637.1 → XP_054220612.1  arginyl-tRNA--protein transferase 1 isoform X7

    15. XM_054364645.1 → XP_054220620.1  arginyl-tRNA--protein transferase 1 isoform X14

    16. XM_054364641.1 → XP_054220616.1  arginyl-tRNA--protein transferase 1 isoform X10

    17. XM_054364639.1 → XP_054220614.1  arginyl-tRNA--protein transferase 1 isoform X9

    18. XM_054364648.1 → XP_054220623.1  arginyl-tRNA--protein transferase 1 isoform X17

    19. XM_054364650.1 → XP_054220625.1  arginyl-tRNA--protein transferase 1 isoform X19

    20. XM_054364653.1 → XP_054220628.1  arginyl-tRNA--protein transferase 1 isoform X26

    21. XM_054364651.1 → XP_054220626.1  arginyl-tRNA--protein transferase 1 isoform X24

    22. XM_054364649.1 → XP_054220624.1  arginyl-tRNA--protein transferase 1 isoform X23

    23. XM_054364652.1 → XP_054220627.1  arginyl-tRNA--protein transferase 1 isoform X25

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O95260.2 GenPept UniProtKB/Swiss-Prot:O95260

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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