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    DCP1B decapping mRNA 1B [ Homo sapiens (human) ]

    Gene ID: 196513, updated on 5-Mar-2024

    Summary

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    Official Symbol
    DCP1Bprovided by HGNC
    Official Full Name
    decapping mRNA 1Bprovided by HGNC
    Primary source
    HGNC:HGNC:24451
    See related
    Ensembl:ENSG00000151065 MIM:609843; AllianceGenome:HGNC:24451
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DCP1
    Summary
    This gene encodes a member of a family of proteins that function in removing the 5' cap from mRNAs, which is a step in regulated mRNA decay. This protein localizes to cytoplasmic foci which are the site of mRNA breakdown and turnover. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
    Expression
    Broad expression in testis (RPKM 7.9), endometrium (RPKM 5.4) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    12p13.33
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (1941591..2004457, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (1937705..2000585, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (2050757..2113623, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene calcium voltage-gated channel auxiliary subunit alpha2delta 4 Neighboring gene uncharacterized LOC124902858 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:2021735-2022235 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:2025891-2026467 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:2042322-2042920 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr12:2063223-2064422 Neighboring gene long intergenic non-protein coding RNA 940 Neighboring gene Sharpr-MPRA regulatory region 10568 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:2112705-2113344 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5813 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr12:2120775-2121283 Neighboring gene CACNA1C intronic transcript 1 Neighboring gene calcium voltage-gated channel subunit alpha1 C Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4127 Neighboring gene CACNA1C intronic transcript 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Two-headed tetraphosphate cap analogs are inhibitors of the Dcp1/2 RNA decapping complex. Ziemniak M, et al. RNA, 2016 Apr. PMID 26826132, Free PMC Article
    2. Cytoplasmic foci are sites of mRNA decay in human cells. Cougot N, et al. J Cell Biol, 2004 Apr. PMID 15067023, Free PMC Article
    3. Identification and characterization of protein interactions in the mammalian mRNA processing body using a novel two-hybrid assay. Bloch DB, et al. Exp Cell Res, 2011 Sep 10. PMID 21672539
    4. A genome-wide association study of overall survival in pancreatic cancer patients treated with gemcitabine in CALGB 80303. Innocenti F, et al. Clin Cancer Res, 2012 Jan 15. PMID 22142827, Free PMC Article
    5. Retroviral GAG proteins recruit AGO2 on viral RNAs without affecting RNA accumulation and translation. Bouttier M, et al. Nucleic Acids Res, 2012 Jan. PMID 21948796, Free PMC Article

    See all (56) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A genome-wide association study of overall survival in pancreatic cancer patients treated with gemcitabine in CALGB 80303.
    EBI GWAS Catalog
    Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.
    EBI GWAS Catalog
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag HIV-1 Gag interacts with DCP1 in a miRNA- and P-body-independent manner PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables enzyme activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in deadenylation-dependent decapping of nuclear-transcribed mRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in deadenylation-independent decapping of nuclear-transcribed mRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in P-body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    		  
    located_in membrane HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    mRNA-decapping enzyme 1B
    Names
    DCP1 decapping enzyme homolog B
    decapping enzyme hDcp1b
    NP_001306221.1
    NP_689853.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001319292.2 → NP_001306221.1  mRNA-decapping enzyme 1B isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks multiple 3' coding exons and extends past a splice site used in variant 1, resulting in a different 3' coding region and 3' UTR. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC005342, AK301109, BM544996, BQ773904, BU930253, DC425587
      Consensus CDS
      CCDS81651.1
      UniProtKB/TrEMBL
      B4DVJ6
      Related
      ENSP00000482714.1, ENST00000535873.2
      Conserved Domains (1) summary
      cd09804
      Location:16 → 108
      Dcp1; mRNA decapping enzyme 1 (Dcp1)

    2. NM_152640.5 → NP_689853.3  mRNA-decapping enzyme 1B isoform 1

      See identical proteins and their annotated locations for NP_689853.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK299203, AW204088, AY146652, BC015368
      Consensus CDS
      CCDS31727.1
      UniProtKB/Swiss-Prot
      B4DRD1, Q86XH9, Q8IZD4, Q96BP8, Q96MZ8
      Related
      ENSP00000280665.6, ENST00000280665.11
      Conserved Domains (2) summary
      cd09804
      Location:16 → 131
      Dcp1; mRNA decapping enzyme 1 (Dcp1)
      pfam16741
      Location:574 → 615
      mRNA_decap_C; mRNA-decapping enzyme C-terminus

    RNA

    1. NR_135060.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) has an alternate internal exon and differs in the 3' exon structure, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC005342, AK299203
      Related
      ENST00000543381.5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      1941591..2004457 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_018654718.1 Reference GRCh38.p14 PATCHES

      Range
      283735..346601 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      1937705..2000585 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IZD4.2 GenPept UniProtKB/Swiss-Prot:Q8IZD4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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