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    Galr3 galanin receptor 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29235, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Galr3provided by RGD
    Official Full Name
    galanin receptor 3provided by RGD
    Primary source
    RGD:2658
    See related
    Ensembl:ENSRNOG00000027060 AllianceGenome:RGD:2658
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables galanin receptor activity. Involved in neuropeptide signaling pathway. Predicted to be located in non-motile cilium. Predicted to be integral component of plasma membrane. Orthologous to human GALR3 (galanin receptor 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 2.3), Lung (RPKM 2.3) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    7q34
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (112483183..112496359)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (110603525..110608429)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (120271451..120276243)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene H1.0 linker histone Neighboring gene glycine C-acetyltransferase Neighboring gene ankyrin repeat domain 54 Neighboring gene transfer RNA valine (anticodon AAC) 17 Neighboring gene eukaryotic translation initiation factor 3, subunit L

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Restricted distribution of galanin receptor 3 (GalR3) mRNA in the adult rat central nervous system. Mennicken F, et al. J Chem Neuroanat, 2002 Nov. PMID 12406501
    2. Distribution of galanin-1, -2 and -3 receptor messenger RNAs in central and peripheral rat tissues. Waters SM, et al. Neuroscience, 2000. PMID 10619483
    3. Cloning and expressional characterization of a novel galanin receptor. Identification of different pharmacophores within galanin for the three galanin receptor subtypes. Wang S, et al. J Biol Chem, 1997 Dec 19. PMID 9405385
    4. A clonal rat pancreatic delta cell line (Rin14B) expresses a high number of galanin receptors negatively coupled to a pertussis-toxin-sensitive cAMP-production pathway. Amiranoff B, et al. Eur J Biochem, 1991 Jan 30. PMID 1847683
    5. Effects of intracerebroventricular galanin or a galanin receptor 2/3 agonist on the lesion induced by transient occlusion of the middle cerebral artery in female rats. Holm L, et al. Neuropeptides, 2011 Feb. PMID 20974494

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that a galanin or a galanin receptor R2/3 agonist doubles the size of the ischemic lesion following middle cerebral artery occlusion in rats.
      Title: Effects of intracerebroventricular galanin or a galanin receptor 2/3 agonist on the lesion induced by transient occlusion of the middle cerebral artery in female rats.
    2. the efficacy of galanin to induce an effective coupling of its receptors to G proteins could be different depending on the brain area
      Title: G protein-coupled galanin receptor distribution in the rat central nervous system.
    3. distribution of GalR3 is contradictory and most studies demonstrated a low expression levels in the rat brain
      Title: Distribution and differential regulation of galanin receptor subtypes in rat brain: effects of seizure activity.
    4. The neuroanatomical distribution of GalR3 suggests it might be involved in mediating documented effects of galanin on food intake, fluid homeostasis, cardiovascular function and nociception.
      Title: Restricted distribution of galanin receptor 3 (GalR3) mRNA in the adult rat central nervous system.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables galanin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables galanin receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables galanin receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables galanin receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables peptide hormone binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptide hormone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables peptide hormone binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in galanin-activated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in galanin-activated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neuropeptide signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neuropeptide signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in non-motile cilium IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in non-motile cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    galanin receptor type 3
    Names
    GAL3-R
    GALR-3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019173.1 → NP_062046.1  galanin receptor type 3

      See identical proteins and their annotated locations for NP_062046.1

      Status: PROVISIONAL

      Source sequence(s)
      AF073798
      UniProtKB/Swiss-Prot
      O54914, O88626, Q9QWZ2
      UniProtKB/TrEMBL
      A0A140TAA9
      Related
      ENSRNOP00000014349.5, ENSRNOT00000014349.6
      Conserved Domains (2) summary
      pfam00001
      Location:34 → 291
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:24 → 162
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      112483183..112496359
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006241972.4 → XP_006242034.1  galanin receptor type 3 isoform X1

      See identical proteins and their annotated locations for XP_006242034.1

      UniProtKB/Swiss-Prot
      O54914, O88626, Q9QWZ2
      UniProtKB/TrEMBL
      A0A140TAA9
      Conserved Domains (2) summary
      pfam00001
      Location:34 → 291
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:24 → 162
      7tm_4; Olfactory receptor
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O88626.1 GenPept UniProtKB/Swiss-Prot:O88626

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous