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    Robo2 roundabout guidance receptor 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 84409, updated on 25-Apr-2024

    Summary

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    Official Symbol
    Robo2provided by RGD
    Official Full Name
    roundabout guidance receptor 2provided by RGD
    Primary source
    RGD:620167
    See related
    Ensembl:ENSRNOG00000029598 AllianceGenome:RGD:620167
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables axon guidance receptor activity. Involved in axon guidance; brain development; and spinal cord development. Predicted to be located in axolemma and cell surface. Human ortholog(s) of this gene implicated in vesicoureteral reflux. Orthologous to human ROBO2 (roundabout guidance receptor 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 136.1), Lung (RPKM 47.8) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    11p11
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (26015919..27583750, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (12528949..14096726, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (11062866..12618793, complement)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA48 Neighboring gene igE-binding protein-like Neighboring gene uncharacterized LOC134480951 Neighboring gene uncharacterized LOC120095537 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC134480952 Neighboring gene transfer RNA alanine (anticodon AGC) 31 Neighboring gene terminal nucleotidyltransferase 5B, pseudogene 1 Neighboring gene U6 spliceosomal RNA Neighboring gene RNA binding motif protein 11 Neighboring gene lipase I

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Slit1 promotes regenerative neurite outgrowth of adult dorsal root ganglion neurons in vitro via binding to the Robo receptor. Zhang HY, et al. J Chem Neuroanat, 2010 Jul. PMID 20172023
    2. Alternatively spliced Robo2 isoforms in zebrafish and rat. Dalkic E, et al. Dev Genes Evol, 2006 Sep. PMID 16625395
    3. Regulation of cortical dendrite development by Slit-Robo interactions. Whitford KL, et al. Neuron, 2002 Jan 3. PMID 11779479
    4. ROBO2 signaling in lung development regulates SOX2/SOX9 balance, branching morphogenesis and is dysregulated in nitrofen-induced congenital diaphragmatic hernia. Gonçalves AN, et al. Respir Res, 2020 Nov 18. PMID 33208157, Free PMC Article
    5. Diversity and specificity of actions of Slit2 proteolytic fragments in axon guidance. Nguyen Ba-Charvet KT, et al. J Neurosci, 2001 Jun 15. PMID 11404413, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ROBO2 signaling in lung development regulates SOX2/SOX9 balance, branching morphogenesis and is dysregulated in nitrofen-induced congenital diaphragmatic hernia.
      Title: ROBO2 signaling in lung development regulates SOX2/SOX9 balance, branching morphogenesis and is dysregulated in nitrofen-induced congenital diaphragmatic hernia.
    2. data revealed a selective and sustained induction of Slit2 and Robo in astrocytes localized throughout the astroglial scar after ischemic stroke, suggesting that Slit2/Robo signaling participates in glial scar formation and brain remodeling following ischemic injury.
      Title: Increased Expression of Slit2 and its Robo Receptors During Astroglial Scar Formation After Transient Focal Cerebral Ischemia in Rats.
    3. Mutations of the SLIT2-ROBO2 pathway genes SLIT2 and SRGAP1 confer risk for congenital anomalies of the kidney and urinary tract
      Title: Mutations of the SLIT2-ROBO2 pathway genes SLIT2 and SRGAP1 confer risk for congenital anomalies of the kidney and urinary tract.
    4. These findings indicate that Slit1/Robo2 signaling may have a role in regulating peripheral nerve regeneration.
      Title: Slit1 promotes regenerative neurite outgrowth of adult dorsal root ganglion neurons in vitro via binding to the Robo receptor.
    5. Data show that at the stage of cerebellofugal axon midline crossing, mRNAs of Robo1 and Robo2 are expressed in the nuclear transitory zone of the cerebellum.
      Title: Crucial roles of Robo proteins in midline crossing of cerebellofugal axons and lack of their up-regulation after midline crossing.
    6. These results suggest that the alternatively spliced robo2 isoforms may exhibit tissue specificity.
      Title: Alternatively spliced Robo2 isoforms in zebrafish and rat.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables axon guidance receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in aorta development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in aortic valve morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in apoptotic process involved in luteolysis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in axon guidance IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within axon guidance ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in axon midline choice point recognition ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in brain development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to hormone stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endocardial cushion formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in heart induction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within metanephros development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of negative chemotaxis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in olfactory bulb interneuron development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in outflow tract septum morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of Notch signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of axonogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in pulmonary valve morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in retinal ganglion cell axon guidance ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spinal cord development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in synapse maturation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ureteric bud development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ventricular septum morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in axolemma ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    is_active_in postsynaptic density membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    roundabout homolog 2
    Names
    roundabout 2

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001415038.1 → NP_001401967.1  roundabout homolog 2 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000011
      Related
      ENSRNOP00000076252.2, ENSRNOT00000093706.2

    2. NM_032106.4 → NP_115289.2  roundabout homolog 2 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/TrEMBL
      A0A1W2Q6F3
      Related
      ENSRNOP00000070966.2, ENSRNOT00000088878.2
      Conserved Domains (6) summary
      cd00063
      Location:522 → 615
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:136 → 139
      Ig; Ig strand A [structural motif]
      cd05726
      Location:315 → 412
      IgI_4_Robo; Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains
      cd07693
      Location:31 → 129
      IgC_1_Robo; First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains
      cd20952
      Location:419 → 505
      IgI_5_Robo; Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains
      cl11960
      Location:136 → 221
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      26015919..27583750 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039088674.2 → XP_038944602.1  roundabout homolog 2 isoform X4

      UniProtKB/TrEMBL
      F1M950
      Conserved Domains (6) summary
      cd00063
      Location:541 → 634
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:151 → 154
      Ig; Ig strand A [structural motif]
      cd05726
      Location:334 → 431
      IgI_4_Robo; Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains
      cd07693
      Location:46 → 144
      IgC_1_Robo; First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains
      cd20952
      Location:438 → 524
      IgI_5_Robo; Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains
      cl11960
      Location:151 → 236
      Ig; Immunoglobulin domain

    2. XM_039088673.2 → XP_038944601.1  roundabout homolog 2 isoform X3

      UniProtKB/TrEMBL
      F1M950
      Conserved Domains (6) summary
      cd00063
      Location:545 → 638
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:159 → 162
      Ig; Ig strand A [structural motif]
      cd05726
      Location:338 → 435
      IgI_4_Robo; Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains
      cd07693
      Location:54 → 152
      IgC_1_Robo; First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains
      cd20952
      Location:442 → 528
      IgI_5_Robo; Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains
      cl11960
      Location:159 → 244
      Ig; Immunoglobulin domain

    3. XM_039088672.2 → XP_038944600.1  roundabout homolog 2 isoform X2

      UniProtKB/TrEMBL
      F1M950
      Conserved Domains (6) summary
      cd00063
      Location:549 → 642
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:159 → 162
      Ig; Ig strand A [structural motif]
      cd05726
      Location:342 → 439
      IgI_4_Robo; Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains
      cd07693
      Location:54 → 152
      IgC_1_Robo; First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains
      cd20952
      Location:446 → 532
      IgI_5_Robo; Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains
      cl11960
      Location:159 → 244
      Ig; Immunoglobulin domain

    4. XM_039088671.2 → XP_038944599.1  roundabout homolog 2 isoform X1

      UniProtKB/TrEMBL
      F1M950
      Conserved Domains (6) summary
      cd00063
      Location:549 → 642
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:159 → 162
      Ig; Ig strand A [structural motif]
      cd05726
      Location:342 → 439
      IgI_4_Robo; Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains
      cd07693
      Location:54 → 152
      IgC_1_Robo; First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains
      cd20952
      Location:446 → 532
      IgI_5_Robo; Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains
      cl11960
      Location:159 → 244
      Ig; Immunoglobulin domain

    5. XM_063270796.1 → XP_063126866.1  roundabout homolog 2 isoform X17

    6. XM_039088680.2 → XP_038944608.1  roundabout homolog 2 isoform X15

      UniProtKB/TrEMBL
      A0A8I6AKD6
      Conserved Domains (6) summary
      cd00063
      Location:549 → 642
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:159 → 162
      Ig; Ig strand A [structural motif]
      cd05726
      Location:342 → 439
      IgI_4_Robo; Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains
      cd07693
      Location:54 → 152
      IgC_1_Robo; First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains
      cd20952
      Location:446 → 532
      IgI_5_Robo; Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains
      cl11960
      Location:159 → 244
      Ig; Immunoglobulin domain

    7. XM_039088677.2 → XP_038944605.1  roundabout homolog 2 isoform X9

      UniProtKB/TrEMBL
      F1M950
      Conserved Domains (6) summary
      cd00063
      Location:549 → 642
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:159 → 162
      Ig; Ig strand A [structural motif]
      cd05726
      Location:342 → 439
      IgI_4_Robo; Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains
      cd07693
      Location:54 → 152
      IgC_1_Robo; First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains
      cd20952
      Location:446 → 532
      IgI_5_Robo; Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains
      cl11960
      Location:159 → 244
      Ig; Immunoglobulin domain

    8. XM_039088687.2 → XP_038944615.1  roundabout homolog 2 isoform X30

      UniProtKB/TrEMBL
      A0A8I6AKD6
      Conserved Domains (6) summary
      cd00063
      Location:549 → 642
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:159 → 162
      Ig; Ig strand A [structural motif]
      cd05726
      Location:342 → 439
      IgI_4_Robo; Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains
      cd07693
      Location:54 → 152
      IgC_1_Robo; First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains
      cd20952
      Location:446 → 532
      IgI_5_Robo; Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains
      cl11960
      Location:159 → 244
      Ig; Immunoglobulin domain

    9. XM_039088676.2 → XP_038944604.1  roundabout homolog 2 isoform X8

      UniProtKB/TrEMBL
      F1M950
      Conserved Domains (6) summary
      cd00063
      Location:545 → 638
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:159 → 162
      Ig; Ig strand A [structural motif]
      cd05726
      Location:338 → 435
      IgI_4_Robo; Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains
      cd07693
      Location:54 → 152
      IgC_1_Robo; First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains
      cd20952
      Location:442 → 528
      IgI_5_Robo; Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains
      cl11960
      Location:159 → 244
      Ig; Immunoglobulin domain

    10. XM_017598079.3 → XP_017453568.1  roundabout homolog 2 isoform X6

      UniProtKB/TrEMBL
      F1M950

    11. XM_063270795.1 → XP_063126865.1  roundabout homolog 2 isoform X12

    12. XM_039088679.2 → XP_038944607.1  roundabout homolog 2 isoform X11

      UniProtKB/TrEMBL
      A0A1W2Q6F3
      Conserved Domains (6) summary
      cd00063
      Location:549 → 642
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:159 → 162
      Ig; Ig strand A [structural motif]
      cd05726
      Location:342 → 439
      IgI_4_Robo; Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains
      cd07693
      Location:54 → 152
      IgC_1_Robo; First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains
      cd20952
      Location:446 → 532
      IgI_5_Robo; Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains
      cl11960
      Location:159 → 244
      Ig; Immunoglobulin domain

    13. XM_063270800.1 → XP_063126870.1  roundabout homolog 2 isoform X24

    14. XM_039088684.2 → XP_038944612.1  roundabout homolog 2 isoform X23

      UniProtKB/TrEMBL
      A0A8I6AKD6
      Conserved Domains (6) summary
      cd00063
      Location:549 → 642
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:159 → 162
      Ig; Ig strand A [structural motif]
      cd05726
      Location:342 → 439
      IgI_4_Robo; Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains
      cd07693
      Location:54 → 152
      IgC_1_Robo; First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains
      cd20952
      Location:446 → 532
      IgI_5_Robo; Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains
      cl11960
      Location:159 → 244
      Ig; Immunoglobulin domain

    15. XM_008768538.4 → XP_008766760.2  roundabout homolog 2 isoform X13

      UniProtKB/TrEMBL
      F1M950

    16. XM_063270798.1 → XP_063126868.1  roundabout homolog 2 isoform X19

    17. XM_063270797.1 → XP_063126867.1  roundabout homolog 2 isoform X18

    18. XM_039088681.2 → XP_038944609.1  roundabout homolog 2 isoform X16

      UniProtKB/TrEMBL
      A0A1W2Q6F3
      Conserved Domains (6) summary
      cd00063
      Location:545 → 638
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:159 → 162
      Ig; Ig strand A [structural motif]
      cd05726
      Location:338 → 435
      IgI_4_Robo; Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains
      cd07693
      Location:54 → 152
      IgC_1_Robo; First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains
      cd20952
      Location:442 → 528
      IgI_5_Robo; Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains
      cl11960
      Location:159 → 244
      Ig; Immunoglobulin domain

    19. XM_017598082.3 → XP_017453571.1  roundabout homolog 2 isoform X14

      UniProtKB/TrEMBL
      A0A1W2Q6F3

    20. XM_017598084.3 → XP_017453573.1  roundabout homolog 2 isoform X25

      UniProtKB/TrEMBL
      A0A8I6AKD6

    21. XM_063270802.1 → XP_063126872.1  roundabout homolog 2 isoform X29

    22. XM_063270801.1 → XP_063126871.1  roundabout homolog 2 isoform X28

    23. XM_039088686.2 → XP_038944614.1  roundabout homolog 2 isoform X27

      UniProtKB/TrEMBL
      A0A8I6A1P7
      Conserved Domains (6) summary
      cd00063
      Location:545 → 638
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:159 → 162
      Ig; Ig strand A [structural motif]
      cd05726
      Location:338 → 435
      IgI_4_Robo; Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains
      cd07693
      Location:54 → 152
      IgC_1_Robo; First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains
      cd20952
      Location:442 → 528
      IgI_5_Robo; Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains
      cl11960
      Location:159 → 244
      Ig; Immunoglobulin domain

    24. XM_039088685.2 → XP_038944613.1  roundabout homolog 2 isoform X26

      UniProtKB/TrEMBL
      A0A8I6AKD6
      Conserved Domains (6) summary
      cd00063
      Location:549 → 642
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:159 → 162
      Ig; Ig strand A [structural motif]
      cd05726
      Location:342 → 439
      IgI_4_Robo; Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains
      cd07693
      Location:54 → 152
      IgC_1_Robo; First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains
      cd20952
      Location:446 → 532
      IgI_5_Robo; Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains
      cl11960
      Location:159 → 244
      Ig; Immunoglobulin domain

    25. XM_039088683.2 → XP_038944611.1  roundabout homolog 2 isoform X22

      UniProtKB/TrEMBL
      A0A0G2JZA1
      Conserved Domains (6) summary
      cd00063
      Location:545 → 638
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:159 → 162
      Ig; Ig strand A [structural motif]
      cd05726
      Location:338 → 435
      IgI_4_Robo; Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains
      cd07693
      Location:54 → 152
      IgC_1_Robo; First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains
      cd20952
      Location:442 → 528
      IgI_5_Robo; Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains
      cl11960
      Location:159 → 244
      Ig; Immunoglobulin domain

    26. XM_039088689.2 → XP_038944617.1  roundabout homolog 2 isoform X34

      UniProtKB/TrEMBL
      A0A8I6AKD6
      Conserved Domains (6) summary
      cd00063
      Location:549 → 642
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:159 → 162
      Ig; Ig strand A [structural motif]
      cd05726
      Location:342 → 439
      IgI_4_Robo; Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains
      cd07693
      Location:54 → 152
      IgC_1_Robo; First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains
      cd20952
      Location:446 → 532
      IgI_5_Robo; Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains
      cl11960
      Location:159 → 244
      Ig; Immunoglobulin domain

    27. XM_063270799.1 → XP_063126869.1  roundabout homolog 2 isoform X21

    28. XM_039088682.2 → XP_038944610.1  roundabout homolog 2 isoform X20

      UniProtKB/TrEMBL
      A0A0G2JZA1
      Conserved Domains (6) summary
      cd00063
      Location:549 → 642
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:159 → 162
      Ig; Ig strand A [structural motif]
      cd05726
      Location:342 → 439
      IgI_4_Robo; Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains
      cd07693
      Location:54 → 152
      IgC_1_Robo; First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains
      cd20952
      Location:446 → 532
      IgI_5_Robo; Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains
      cl11960
      Location:159 → 244
      Ig; Immunoglobulin domain

    29. XM_039088688.2 → XP_038944616.1  roundabout homolog 2 isoform X33

      UniProtKB/TrEMBL
      A0A8I6A1P7
      Conserved Domains (6) summary
      cd00063
      Location:545 → 638
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:159 → 162
      Ig; Ig strand A [structural motif]
      cd05726
      Location:338 → 435
      IgI_4_Robo; Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains
      cd07693
      Location:54 → 152
      IgC_1_Robo; First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains
      cd20952
      Location:442 → 528
      IgI_5_Robo; Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains
      cl11960
      Location:159 → 244
      Ig; Immunoglobulin domain

    30. XM_063270803.1 → XP_063126873.1  roundabout homolog 2 isoform X32

    31. XM_008768539.4 → XP_008766761.2  roundabout homolog 2 isoform X31

      UniProtKB/TrEMBL
      A0A8I6AKD6
      Related
      ENSRNOP00000089188.1

    32. XM_039088678.2 → XP_038944606.1  roundabout homolog 2 isoform X10

      UniProtKB/TrEMBL
      F1M950
      Conserved Domains (6) summary
      cd00063
      Location:522 → 615
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:136 → 139
      Ig; Ig strand A [structural motif]
      cd05726
      Location:315 → 412
      IgI_4_Robo; Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains
      cd07693
      Location:31 → 129
      IgC_1_Robo; First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains
      cd20952
      Location:419 → 505
      IgI_5_Robo; Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains
      cl11960
      Location:136 → 221
      Ig; Immunoglobulin domain

    33. XM_063270794.1 → XP_063126864.1  roundabout homolog 2 isoform X7

    34. XM_039088675.2 → XP_038944603.1  roundabout homolog 2 isoform X5

      UniProtKB/TrEMBL
      F1M950
      Related
      ENSRNOP00000061003.4
      Conserved Domains (6) summary
      cd00063
      Location:526 → 619
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:136 → 139
      Ig; Ig strand A [structural motif]
      cd05726
      Location:319 → 416
      IgI_4_Robo; Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains
      cd07693
      Location:31 → 129
      IgC_1_Robo; First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains
      cd20952
      Location:423 → 509
      IgI_5_Robo; Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains
      cl11960
      Location:136 → 221
      Ig; Immunoglobulin domain

    35. XM_063270804.1 → XP_063126874.1  roundabout homolog 2 isoform X35

    Nucleotide Protein Strain
    Heading Accession and Version

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