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    NBAT1 neuroblastoma associated transcript 1 [ Homo sapiens (human) ]

    Gene ID: 729177, updated on 10-Mar-2024

    Summary

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    Official Symbol
    NBAT1provided by HGNC
    Official Full Name
    neuroblastoma associated transcript 1provided by HGNC
    Primary source
    HGNC:HGNC:49075
    See related
    MIM:616206; AllianceGenome:HGNC:49075
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CASC14; NBAT-1
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    Location:
    6p22.3
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (22134602..22147193, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (22007424..22020017, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (22134831..22147422, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene cancer susceptibility 15 Neighboring gene uncharacterized LOC105374970 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24143 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24144 Neighboring gene Sharpr-MPRA regulatory region 6328 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16987 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr6:21873881-21875080 Neighboring gene Sharpr-MPRA regulatory region 8833 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24145 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24146 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24147 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:22027355-22028066 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24148 Neighboring gene RN7SK pseudogene 240 Neighboring gene NANOG hESC enhancer GRCh37_chr6:22145447-22145948 Neighboring gene VISTA enhancer hs1335 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr6:22198729-22199928 Neighboring gene uncharacterized LOC124901275 Neighboring gene NGRN pseudogene 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. lncRNA NBAT1 Inhibits Cell Metastasis and Promotes Apoptosis in Endometrial Cancer by Sponging miR-21-5p to Regulate PTEN. Tian C, et al. Comput Math Methods Med, 2022. PMID 35912140, Free PMC Article
    2. Expression of long noncoding RNA NBAT1 is associated with the outcome of patients with non-small cell lung cancer. Wang DL, et al. Rev Assoc Med Bras (1992), 2020 Jul. PMID 32844929
    3. Effect of downregulated lncRNA NBAT1 on the biological behavior of glioblastoma cells. Liu J, et al. Eur Rev Med Pharmacol Sci, 2018 May. PMID 29771423
    4. LncRNA NBAT-1 is down-regulated in lung cancer and influences cell proliferation, apoptosis and cell cycle. Lei T, et al. Eur Rev Med Pharmacol Sci, 2018 Apr. PMID 29687849
    5. Fighting Neuroblastomas with NBAT1. Pandey GK, et al. Oncoscience, 2015. PMID 25859549, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Expression level and clinical significance of NBAT-1 in human cancers: a systematic review and meta-analysis.
      Title: Expression level and clinical significance of NBAT-1 in human cancers: a systematic review and meta-analysis.
    2. Serum lncRNAs, NBAT-1, and FOXCUT signature in hepatocellular carcinoma developed on top of chronic hepatitis C.
      Title: Serum lncRNAs, NBAT-1, and FOXCUT signature in hepatocellular carcinoma developed on top of chronic hepatitis C.
    3. Long noncoding RNA NBAT1 suppresses hepatocellular carcinoma progression via competitively associating with IGF2BP1 and decreasing c-Myc expression.
      Title: Long noncoding RNA NBAT1 suppresses hepatocellular carcinoma progression via competitively associating with IGF2BP1 and decreasing c-Myc expression.
    4. Subcellular Distribution of p53 by the p53-Responsive lncRNA NBAT1 Determines Chemotherapeutic Response in Neuroblastoma.
      Title: Subcellular Distribution of p53 by the p53-Responsive lncRNA NBAT1 Determines Chemotherapeutic Response in Neuroblastoma.
    5. Expression of long noncoding RNA NBAT1 is associated with the outcome of patients with non-small cell lung cancer.
      Title: Expression of long noncoding RNA NBAT1 is associated with the outcome of patients with non-small cell lung cancer.
    6. Low NBAT1 expression is associated with cell proliferation, migration, and invasion in renal carcinoma.
      Title: LncRNA NBAT1 suppresses cell proliferation and migration via miR-346/GSK-3β axis in renal carcinoma.
    7. NBAT-1 overexpression remarkably upregulated PTEN expression in gastric cancer (GC) cells. Low expression of NBAT-1 promotes GC development by downregulating PTEN expression.
      Title: Low expression of lncRNA NBAT-1 promotes gastric cancer development and is associated with poor prognosis.
    8. Up-regulation of NBAT1 inhibited proliferative activities of glioblastoma tumor cells by regulating Akt activity.
      Title: Effect of downregulated lncRNA NBAT1 on the biological behavior of glioblastoma cells.
    9. The overexpression of lncRNA NBAT-1 could inhibit the proliferation and cell cycle, promote the apoptosis of A549 cells, and down-regulate the expression level of RAC1.
      Title: LncRNA NBAT-1 is down-regulated in lung cancer and influences cell proliferation, apoptosis and cell cycle.
    10. DKK1 is found to be regulated by NBAT1 in a PRC2 dependent manner, and is responsible for NBAT1's effects in inhibiting migration and invasion of breast cancer cells.
      Title: NBAT1 suppresses breast cancer metastasis by regulating DKK1 via PRC2.
    Submit: New GeneRIF Correction See all GeneRIFs (11)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Chromosome 6p22 locus associated with clinically aggressive neuroblastoma.
    EBI GWAS Catalog
    Common variation at 6q16 within HACE1 and LIN28B influences susceptibility to neuroblastoma.
    EBI GWAS Catalog
    Integrative genomics identifies LMO1 as a neuroblastoma oncogene.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    General gene information

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    Markers

    Other Names

    • cancer susceptibility candidate 14 (non-protein coding)

    Clone Names

    • FLJ44180

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_034143.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AK126168, AL008732, H15083

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      22134602..22147193 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      22007424..22020017 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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    Research Materials