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    dpy-8 Nematode cuticle collagen N-terminal domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 180785, updated on 25-Apr-2024

    Summary

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    Gene symbol
    dpy-8
    Gene description
    Nematode cuticle collagen N-terminal domain-containing protein
    Primary source
    WormBase:WBGene00001070
    Locus tag
    CELE_C31H2.2
    See related
    AllianceGenome:WB:WBGene00001070
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be a structural constituent of cuticle. Involved in cuticle development involved in collagen and cuticulin-based cuticle molting cycle. Predicted to be located in membrane. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: X
    Exon count:
    4
    Sequence:
    Chromosome: X; NC_003284.9 (5148804..5150476, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Rab-GAP TBC domain-containing protein;TLDc domain-containing protein Neighboring gene ncRNA Neighboring gene Ovule protein Neighboring gene Uncharacterized protein Neighboring gene Putative protein C31H2.4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genes that can be mutated to unmask hidden antigenic determinants in the cuticle of the nematode Caenorhabditis elegans. Politz SM, et al. Proc Natl Acad Sci U S A, 1990 Apr. PMID 1691498, Free PMC Article
    2. Identification of genes that interact with glp-1, a gene required for inductive cell interactions in Caenorhabditis elegans. Maine EM, et al. Development, 1989 May. PMID 2627884
    3. Genetics of intercellular signalling in C. elegans. Austin J, et al. Development, 1989. PMID 2699857
    4. Two sets of interacting collagens form functionally distinct substructures within a Caenorhabditis elegans extracellular matrix. McMahon L, et al. Mol Biol Cell, 2003 Apr. PMID 12686594, Free PMC Article
    5. BIR-1, the homologue of human Survivin, regulates expression of developmentally active collagen genes in C. elegans. Libý P, et al. Folia Biol (Praha), 2006. PMID 17116281

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables structural constituent of cuticle IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in anatomical structure development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cuticle development involved in collagen and cuticulin-based cuticle molting cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of collagen trimer IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Nematode cuticle collagen N-terminal domain-containing protein
    NP_508873.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      5148804..5150476 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_076472.4 → NP_508873.1  Nematode cuticle collagen N-terminal domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_508873.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q18345
      Conserved Domains (1) summary
      smart01088
      Location:7 → 58
      Col_cuticle_N; Nematode cuticle collagen N-terminal domain
    Nucleotide Protein
    Heading Accession and Version

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