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Breast giant fibroadenoma

MedGen UID:
138039
•Concept ID:
C0346157
•
Neoplastic Process
Synonym: Giant adenofibroma of the breast
SNOMED CT: Giant fibroadenoma of breast (254846003); Serocystic disease of Brodie (254846003)
 
Monarch Initiative: MONDO:0004150

Definition

A breast fibroadenoma characterized by a very large size. This term has also been used as a synonym for juvenile fibroadenoma by some authors. The latter is characterized by epithelial hyperplasia and an increased stromal cellularity. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBreast giant fibroadenoma

Professional guidelines

PubMed

Differential diagnosis between fibroadenoma, giant fibroadenoma and phyllodes tumour: sonographic features and core needle biopsy.
Gatta G, Iaselli F, Parlato V, Di Grezia G, Grassi R, Rotondo A
Radiol Med 2011 Sep;116(6):905-18. Epub 2011 Apr 19 doi: 10.1007/s11547-011-0672-y. PMID: 21509559
Diagnosis and treatment of symptomatic breast masses in the pediatric population.
West KW, Rescorla FJ, Scherer LR 3rd, Grosfeld JL
J Pediatr Surg 1995 Feb;30(2):182-6; discussion 186-7. doi: 10.1016/0022-3468(95)90557-x. PMID: 7738735
Practical aspects in the diagnosis and management of cystosarcoma phyllodes.
Hart J, Layfield LJ, Trumbull WE, Brayton D, Barker WF, Giuliano AE
Arch Surg 1988 Sep;123(9):1079-83. doi: 10.1001/archsurg.1988.01400330055008. PMID: 2843145

Recent clinical studies

Etiology

Surgical management of giant juvenile fibroadenoma with skin reducing tumor resection and immediate breast reconstruction: A single-center experience.
Du F, Dong R, Zeng A, Liu Z, Yu N, Wang X, Zhu L
J Surg Oncol 2020 Mar;121(3):441-446. Epub 2020 Jan 6 doi: 10.1002/jso.25828. PMID: 31907948
Intermediate and Long-term Outcomes of Giant Fibroadenoma Excision in Adolescent and Young Adult Patients.
Cerrato FE, Pruthi S, Boughey JC, Simmons PS, Salje B, Nuzzi LC, Lemaine V, Labow BI
Breast J 2015 May-Jun;21(3):254-9. Epub 2015 Mar 13 doi: 10.1111/tbj.12394. PMID: 25772491
Breast diseases in adolescents.
Duflos C, Plu-Bureau G, Thibaud E, Kuttenn F
Endocr Dev 2012;22:208-221. Epub 2012 Jul 25 doi: 10.1159/000326690. PMID: 22846531
Fibroadenomas in adolescence.
Jayasinghe Y, Simmons PS
Curr Opin Obstet Gynecol 2009 Oct;21(5):402-6. doi: 10.1097/GCO.0b013e32832fa06b. PMID: 19606032
Breast disorders in children and adolescents.
Greydanus DE, Matytsina L, Gains M
Prim Care 2006 Jun;33(2):455-502. doi: 10.1016/j.pop.2006.02.002. PMID: 16713771

Diagnosis

The largest and heaviest giant juvenile fibroadenoma of the breast in the Chinese population: A case report.
Zhang Y, Huang J, Zhou L, Leng Y
Medicine (Baltimore) 2023 Mar 31;102(13):e33422. doi: 10.1097/MD.0000000000033422. PMID: 37000060Free PMC Article
Giant juvenile fibroadenoma of the breast in a 12-year-old girl.
Dasgupta R, Rajak TK, Kaushal S, Ritolia N
Afr J Paediatr Surg 2022 Oct-Dec;19(4):271-273. doi: 10.4103/ajps.ajps_75_21. PMID: 36018214Free PMC Article
Fibroadenomas: a multidisciplinary review of the variants.
Basara Akin I, Balci P
Clin Imaging 2021 Mar;71:83-100. Epub 2020 Nov 6 doi: 10.1016/j.clinimag.2020.10.058. PMID: 33186871
Largest giant juvenile fibroadenoma of the breast.
Islam S, Saroop S, Bheem V, Naraynsingh V
BMJ Case Rep 2019 Jan 28;12(1) doi: 10.1136/bcr-2018-227277. PMID: 30696639Free PMC Article
Breast diseases in adolescents.
Duflos C, Plu-Bureau G, Thibaud E, Kuttenn F
Endocr Dev 2012;22:208-221. Epub 2012 Jul 25 doi: 10.1159/000326690. PMID: 22846531

Therapy

Surgical management of giant juvenile fibroadenoma with skin reducing tumor resection and immediate breast reconstruction: A single-center experience.
Du F, Dong R, Zeng A, Liu Z, Yu N, Wang X, Zhu L
J Surg Oncol 2020 Mar;121(3):441-446. Epub 2020 Jan 6 doi: 10.1002/jso.25828. PMID: 31907948
A Unique Four-Point Approach for Removal of Giant Breast Fibroadenoma With Marked Asymmetry: A Modified Round Block Technique.
Cui H, Liu J, Guo J, Hu S, Xiang A, Ma S
J Invest Surg 2020 Sep;33(8):709-714. Epub 2019 May 9 doi: 10.1080/08941939.2019.1568647. PMID: 31070071
Differential diagnosis and management of giant fibroadenoma: comparing excision with reduction mammoplasty incision and excision with inframammary incision.
Ugburo AO, Olajide TO, Fadeyibi IO, Mofikoya BO, Lawal AO, Osinowo AO
J Plast Surg Hand Surg 2012 Oct;46(5):354-8. doi: 10.3109/2000656X.2012.697066. PMID: 22998148
Abnormal mammography and sonography associated with foreign-body giant-cell reaction after stereotactic vacuum-assisted breast biopsy with carbon marking.
Ruiz-Delgado ML, López-Ruiz JA, Sáiz-López A
Acta Radiol 2008 Dec;49(10):1112-8. doi: 10.1080/02841850802452075. PMID: 18932053
Congenital and acquired pediatric breast anomalies: a review of 20 years' experience.
Sadove AM, van Aalst JA
Plast Reconstr Surg 2005 Apr;115(4):1039-50. doi: 10.1097/01.prs.0000154214.99641.72. PMID: 15793443

Prognosis

Gene expression profiling of giant fibroadenomas of the breast.
Yin Lee JP, Thomas AJ, Lum SK, Shamsudin NH, Hii LW, Mai CW, Wong SF, Leong CO
Surg Oncol 2021 Jun;37:101536. Epub 2021 Mar 2 doi: 10.1016/j.suronc.2021.101536. PMID: 33677364
Surgical management of giant juvenile fibroadenoma with skin reducing tumor resection and immediate breast reconstruction: A single-center experience.
Du F, Dong R, Zeng A, Liu Z, Yu N, Wang X, Zhu L
J Surg Oncol 2020 Mar;121(3):441-446. Epub 2020 Jan 6 doi: 10.1002/jso.25828. PMID: 31907948
Surgery for giant tumours of the breast: a 15 year review.
Daya M, Balakrishnan T
S Afr J Surg 2018 Sep;56(3):9-15. PMID: 30264936
Intermediate and Long-term Outcomes of Giant Fibroadenoma Excision in Adolescent and Young Adult Patients.
Cerrato FE, Pruthi S, Boughey JC, Simmons PS, Salje B, Nuzzi LC, Lemaine V, Labow BI
Breast J 2015 May-Jun;21(3):254-9. Epub 2015 Mar 13 doi: 10.1111/tbj.12394. PMID: 25772491
From the archives of the AFIP: breast masses in children and adolescents: radiologic-pathologic correlation.
Chung EM, Cube R, Hall GJ, González C, Stocker JT, Glassman LM
Radiographics 2009 May-Jun;29(3):907-31. doi: 10.1148/rg.293095010. PMID: 19448124

Clinical prediction guides

Giant juvenile fibroadenomas with and without prominent pseudoangiomatous stromal hyperplasia (PASH)-like change: clinicopathological and molecular characteristics.
Jorns JM, Farooq A, Puzyrenko A, Jarzembowski J, Thike AA, Nasir NDM, Ng CCY, Liu W, Lee JY, Lim AH, Guan P, Teh BT, Tan PH
Histopathology 2023 Sep;83(3):357-365. Epub 2023 May 4 doi: 10.1111/his.14935. PMID: 37140543
Gene expression profiling of giant fibroadenomas of the breast.
Yin Lee JP, Thomas AJ, Lum SK, Shamsudin NH, Hii LW, Mai CW, Wong SF, Leong CO
Surg Oncol 2021 Jun;37:101536. Epub 2021 Mar 2 doi: 10.1016/j.suronc.2021.101536. PMID: 33677364
Surgical management of giant juvenile fibroadenoma with skin reducing tumor resection and immediate breast reconstruction: A single-center experience.
Du F, Dong R, Zeng A, Liu Z, Yu N, Wang X, Zhu L
J Surg Oncol 2020 Mar;121(3):441-446. Epub 2020 Jan 6 doi: 10.1002/jso.25828. PMID: 31907948
Differential diagnosis between fibroadenoma, giant fibroadenoma and phyllodes tumour: sonographic features and core needle biopsy.
Gatta G, Iaselli F, Parlato V, Di Grezia G, Grassi R, Rotondo A
Radiol Med 2011 Sep;116(6):905-18. Epub 2011 Apr 19 doi: 10.1007/s11547-011-0672-y. PMID: 21509559
FNA of breast fibroadenoma: observer variability and review of cytomorphology with cytohistological correlation.
Kollur SM, El Hag IA
Cytopathology 2006 Oct;17(5):239-44. doi: 10.1111/j.1365-2303.2006.00360.x. PMID: 16961651

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