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Advanced Bladder Carcinoma

MedGen UID:
1718946
•Concept ID:
C5238474
•
Neoplastic Process

Definition

A bladder carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdvanced Bladder Carcinoma

Professional guidelines

PubMed

The Challenge of Managing Bladder Cancer and Upper Tract Urothelial Carcinoma: A Review with Treatment Recommendations from the Spanish Oncology Genitourinary Group (SOGUG).
Font A, Luque R, Villa JC, Domenech M, Vázquez S, Gallardo E, Virizuela JA, Beato C, Morales-Barrera R, Gelabert A, Maciá S, Puente J, Rubio G, Maldonado X, Perez-Valderrama B, Pinto A, Fernández Calvo O, Grande E, Garde-Noguera J, Fernández-Parra E, Arranz JÁ
Target Oncol 2019 Feb;14(1):15-32. doi: 10.1007/s11523-019-00619-7. PMID: 30694442
Sunitinib malate and sorafenib may be beneficial at the treatment of advanced bladder cancer due to their anti-angiogenic effects.
Silay MS, Miroglu C
Med Hypotheses 2007;69(4):892-5. Epub 2007 Mar 26 doi: 10.1016/j.mehy.2007.01.065. PMID: 17368754
Treatment of advanced bladder carcinoma with irradiation and concomitant 5-fluorouracil infusion.
Rotman M, Macchia R, Silverstein M, Aziz H, Choi K, Rosenthal J, Braverman A, Laungani GB
Cancer 1987 Feb 15;59(4):710-4. doi: 10.1002/1097-0142(19870215)59:4<710::aid-cncr2820590408>3.0.co;2-u. PMID: 3802030

Recent clinical studies

Etiology

Radiotherapy with concurrent carbogen and nicotinamide in bladder carcinoma.
Hoskin PJ, Rojas AM, Bentzen SM, Saunders MI
J Clin Oncol 2010 Nov 20;28(33):4912-8. Epub 2010 Oct 18 doi: 10.1200/JCO.2010.28.4950. PMID: 20956620
Clinical outcome in patients with locally advanced bladder carcinoma treated with conservative multimodality therapy.
George L, Bladou F, Bardou VJ, Gravis G, Tallet A, Alzieu C, Serment G, Salem N
Urology 2004 Sep;64(3):488-93. doi: 10.1016/j.urology.2004.04.088. PMID: 15351577
Gemcitabine and carboplatin combination as first-line treatment in elderly patients and those unfit for cisplatin-based chemotherapy with advanced bladder carcinoma: Phase II study of the Hellenic Co-operative Oncology Group.
Linardou H, Aravantinos G, Efstathiou E, Kalofonos C, Anagnostopoulos A, Deliveliotis C, Bafaloukos D, Athanasios Dimopoulos M, Bamias A; Phase II study of Hellenic Co-operative Oncology Group
Urology 2004 Sep;64(3):479-84. doi: 10.1016/j.urology.2004.04.024. PMID: 15351574
Symptomatic relief of patients with advanced bladder carcinoma after regional intra-arterial chemotherapy.
Mantadakis E, Panagiotidis C, Delakas D, Samonis G
Anticancer Res 2003 Nov-Dec;23(6D):5143-7. PMID: 14981980
Carboplatin-based versus cisplatin-based chemotherapy in the treatment of surgically incurable advanced bladder carcinoma.
Bellmunt J, Ribas A, Eres N, Albanell J, Almanza C, Bermejo B, Solé LA, Baselga J
Cancer 1997 Nov 15;80(10):1966-72. doi: 10.1002/(sici)1097-0142(19971115)80:10<1966::aid-cncr14>3.0.co;2-w. PMID: 9366300

Diagnosis

Bladder carcinoma during pregnancy.
Spahn M, Bader P, Westermann D, Echtle D, Frohneberg D
Urol Int 2005;74(2):153-9. doi: 10.1159/000083287. PMID: 15756068
Cytostatic sensitivity and MDR in bladder carcinoma cells: implications for tumor therapy.
Schuldes H, Dolderer JH, Schoch C, Bickeböller R, Woodcock BG
Int J Clin Pharmacol Ther 2000 Apr;38(4):204-8. doi: 10.5414/cpp38204. PMID: 10783830
CMV front-line chemotherapy in transitional bladder carcinoma.
Paz-Ares L, Lianes P, Díaz-Puente M, Rivera F, Passas J, Costas P, Mendiola C, Cortés-Funes H
Ann Oncol 1993 Feb;4(2):147-50. doi: 10.1093/oxfordjournals.annonc.a058418. PMID: 8448083
Altered expression of retinoblastoma protein and known prognostic variables in locally advanced bladder cancer.
Logothetis CJ, Xu HJ, Ro JY, Hu SX, Sahin A, Ordonez N, Benedict WF
J Natl Cancer Inst 1992 Aug 19;84(16):1256-61. doi: 10.1093/jnci/84.16.1256. PMID: 1640485
Radical radiation treatment of invasive and locally advanced bladder carcinoma in elderly patients.
Smaaland R, Akslen LA, Tønder B, Mehus A, Lote K, Albrektsen G
Br J Urol 1991 Jan;67(1):61-9. doi: 10.1111/j.1464-410x.1991.tb15071.x. PMID: 1993278

Therapy

Neoadjuvant and adjuvant chemotherapy for locally advanced bladder carcinoma: development of novel bladder preservation approach, Osaka Medical College regimen.
Azuma H, Inamoto T, Takahara K, Ibuki N, Nomi H, Yamamoto K, Narumi Y, Ubai T
Int J Urol 2012 Jan;19(1):26-38. Epub 2011 Nov 13 doi: 10.1111/j.1442-2042.2011.02856.x. PMID: 22077821
Carbogen and nicotinamide in locally advanced bladder cancer: early results of a phase-III randomized trial.
Hoskin PJ, Rojas AM, Saunders MI, Bentzen SM, Motohashi KJ; BCON investigators
Radiother Oncol 2009 Apr;91(1):120-5. Epub 2008 Nov 5 doi: 10.1016/j.radonc.2008.10.001. PMID: 18992952
Acute and late morbidity in the treatment of advanced bladder carcinoma with accelerated radiotherapy, carbogen, and nicotinamide.
Hoskin PJ, Rojas AM, Phillips H, Saunders MI
Cancer 2005 Jun 1;103(11):2287-97. doi: 10.1002/cncr.21048. PMID: 15834926
Clinical outcome in patients with locally advanced bladder carcinoma treated with conservative multimodality therapy.
George L, Bladou F, Bardou VJ, Gravis G, Tallet A, Alzieu C, Serment G, Salem N
Urology 2004 Sep;64(3):488-93. doi: 10.1016/j.urology.2004.04.088. PMID: 15351577
The chemotherapy of advanced bladder carcinoma.
deKernion JB
Cancer Res 1977 Aug;37(8 Pt 2):2771-4. PMID: 326391

Prognosis

Sunitinib malate and sorafenib may be beneficial at the treatment of advanced bladder cancer due to their anti-angiogenic effects.
Silay MS, Miroglu C
Med Hypotheses 2007;69(4):892-5. Epub 2007 Mar 26 doi: 10.1016/j.mehy.2007.01.065. PMID: 17368754
Acute and late morbidity in the treatment of advanced bladder carcinoma with accelerated radiotherapy, carbogen, and nicotinamide.
Hoskin PJ, Rojas AM, Phillips H, Saunders MI
Cancer 2005 Jun 1;103(11):2287-97. doi: 10.1002/cncr.21048. PMID: 15834926
Bladder carcinoma during pregnancy.
Spahn M, Bader P, Westermann D, Echtle D, Frohneberg D
Urol Int 2005;74(2):153-9. doi: 10.1159/000083287. PMID: 15756068
Single-agent gemcitabine in previously untreated elderly patients with advanced bladder carcinoma: response to treatment and correlation with the comprehensive geriatric assessment.
Castagneto B, Zai S, Marenco D, Bertetto O, Repetto L, Scaltriti L, Mencoboni M, Ferraris V, Botta M
Oncology 2004;67(1):27-32. doi: 10.1159/000080282. PMID: 15459492
Clinical outcome in patients with locally advanced bladder carcinoma treated with conservative multimodality therapy.
George L, Bladou F, Bardou VJ, Gravis G, Tallet A, Alzieu C, Serment G, Salem N
Urology 2004 Sep;64(3):488-93. doi: 10.1016/j.urology.2004.04.088. PMID: 15351577

Clinical prediction guides

Accelerated radiotherapy, carbogen, and nicotinamide (ARCON) in the treatment of advanced bladder cancer: mature results of a Phase II nonrandomized study.
Hoskin P, Rojas A, Saunders M
Int J Radiat Oncol Biol Phys 2009 Apr 1;73(5):1425-31. Epub 2008 Nov 25 doi: 10.1016/j.ijrobp.2008.06.1950. PMID: 19036531
Gemcitabine plus vinorelbine chemotherapy in patients with advanced bladder carcinoma who are medically unsuitable for or who have failed cisplatin-based chemotherapy.
Türkölmez K, Bedük Y, Baltaci S, Göğüş C, Göğüş O
Eur Urol 2003 Dec;44(6):682-6. doi: 10.1016/s0302-2838(03)00385-3. PMID: 14644120
Carboplatin-based versus cisplatin-based chemotherapy in the treatment of surgically incurable advanced bladder carcinoma.
Bellmunt J, Ribas A, Eres N, Albanell J, Almanza C, Bermejo B, Solé LA, Baselga J
Cancer 1997 Nov 15;80(10):1966-72. doi: 10.1002/(sici)1097-0142(19971115)80:10<1966::aid-cncr14>3.0.co;2-w. PMID: 9366300
Feasibility, toxicity, and preliminary results of weekly loco-regional hyperthermia and cisplatin in patients with previously irradiated recurrent cervical carcinoma or locally advanced bladder cancer.
Rietbroek RC, Bakker PJ, Schilthuis MS, Postma AJ, Zum Vörde Sive Vording PJ, Gonzalèz Gonzalèz D, Kurth KH, Bakker AJ, Veenhof CH
Int J Radiat Oncol Biol Phys 1996 Mar 1;34(4):887-93. doi: 10.1016/0360-3016(95)02152-3. PMID: 8598366
CMV front-line chemotherapy in transitional bladder carcinoma.
Paz-Ares L, Lianes P, Díaz-Puente M, Rivera F, Passas J, Costas P, Mendiola C, Cortés-Funes H
Ann Oncol 1993 Feb;4(2):147-50. doi: 10.1093/oxfordjournals.annonc.a058418. PMID: 8448083

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