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Castleman Disease, Hyaline-Vascular Type

MedGen UID:
231376
•Concept ID:
C1332293
•
Neoplastic Process
Synonyms: Angiofollicular Lymphoid Hyperplasia, Hyaline-Vascular Type; Castleman's Disease, Hyaline-Vascular Type

Definition

The commonest type of Castleman disease. It is seen most commonly in the mediastinum. Histologically this is characterized by hyalinized germinal centers surrounded by small lymphocytes in a concentric fashion, giving an onion skin appearance. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCastleman Disease, Hyaline-Vascular Type

Professional guidelines

PubMed

Clinical features and treatment outcomes of Castleman disease in children: a retrospective cohort in China.
Hu S, Li Z, Wang H, Chen L, Ma Y, Zhu X, Li J, Dong R, Yao W, Dong C, Zhang H, Li K, Dong K, Zhai X
Eur J Pediatr 2023 Dec;182(12):5519-5530. Epub 2023 Oct 2 doi: 10.1007/s00431-023-05235-2. PMID: 37782352Free PMC Article
The clinicopathological behaviour and surgical treatment of abdominal Castleman's disease.
Han SL, Chen XX, Zheng XF, Yan JY, Shen X, Zhu GB
Singapore Med J 2010 Oct;51(10):813-6. PMID: 21103818
The management of unicentric and multicentric Castleman's disease: a report of 16 cases and a review of the literature.
Bowne WB, Lewis JJ, Filippa DA, Niesvizky R, Brooks AD, Burt ME, Brennan MF
Cancer 1999 Feb 1;85(3):706-17. doi: 10.1002/(sici)1097-0142(19990201)85:3<706::aid-cncr21>3.0.co;2-7. PMID: 10091744

Recent clinical studies

Etiology

A Case of Unicentric Castleman Disease with Concomitant Myasthenia Gravis and Persistent Left Superior Vena Cava.
Cardwell M, Lu MS, Melamed J, Astle J, Gasparri M, Johnstone DW
Am J Case Rep 2023 Feb 2;24:e938305. doi: 10.12659/AJCR.938305. PMID: 36726305Free PMC Article
Clinical analysis of Castleman disease (hyaline vascular type) in parotid and neck region.
Zhong LP, Wang LZ, Ji T, Hu YH, Hu YJ, Ye WM, Li J, Sun J, Zhu HG, Li J, Zhang CP
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2010 Mar;109(3):432-40. Epub 2009 Dec 6 doi: 10.1016/j.tripleo.2009.09.025. PMID: 19969478
Cervical Castleman disease in children.
Zhong LP, Chen GF, Zhao SF
Br J Oral Maxillofac Surg 2004 Feb;42(1):69-71. doi: 10.1016/s0266-4356(03)00204-3. PMID: 14706308

Diagnosis

A unicentric center, multicenter, and mixed-type Castleman disease: Three case reports and a review of the literature.
Xu Y, Shao S, Kang H, Xu Z, Wen G, Shan Y, Gong Z, Al-Sharabi A, Qu B, Ren Y, Zhang F, Guan J, Chen X
Medicine (Baltimore) 2024 Apr 12;103(15):e37722. doi: 10.1097/MD.0000000000037722. PMID: 38608101Free PMC Article
A Case of Unicentric Castleman Disease with Concomitant Myasthenia Gravis and Persistent Left Superior Vena Cava.
Cardwell M, Lu MS, Melamed J, Astle J, Gasparri M, Johnstone DW
Am J Case Rep 2023 Feb 2;24:e938305. doi: 10.12659/AJCR.938305. PMID: 36726305Free PMC Article
Treatment of unicentric Castleman disease with neoadjuvant rituximab.
Bandera B, Ainsworth C, Shikle J, Rupard E, Roach M
Chest 2010 Nov;138(5):1239-41. doi: 10.1378/chest.09-2084. PMID: 21051400
Clinical analysis of Castleman disease (hyaline vascular type) in parotid and neck region.
Zhong LP, Wang LZ, Ji T, Hu YH, Hu YJ, Ye WM, Li J, Sun J, Zhu HG, Li J, Zhang CP
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2010 Mar;109(3):432-40. Epub 2009 Dec 6 doi: 10.1016/j.tripleo.2009.09.025. PMID: 19969478
Rare case of Castleman disease involving the pancreas.
Tunru-Dinh VW, Ghani A, Tom YD
Am Surg 2007 Dec;73(12):1284-7. PMID: 18186391

Therapy

Treatment of unicentric Castleman disease with neoadjuvant rituximab.
Bandera B, Ainsworth C, Shikle J, Rupard E, Roach M
Chest 2010 Nov;138(5):1239-41. doi: 10.1378/chest.09-2084. PMID: 21051400
Development of a calcifying fibrous pseudotumour within a lesion of Castleman disease, hyaline-vascular subtype.
Dargent JL, Delplace J, Roufosse C, Laget JP, Lespagnard L
J Clin Pathol 1999 Jul;52(7):547-9. doi: 10.1136/jcp.52.7.547. PMID: 10605414Free PMC Article

Prognosis

Exuberant cortical thymocyte proliferation mimicking T-lymphoblastic lymphoma within recurrent large inguinal lymph node masses of localized Castleman disease.
Kansal R, Nathwani BN, Yiakoumis X, Moschogiannis M, Sachanas S, Stefanaki K, Pangalis GA
Hum Pathol 2015 Jul;46(7):1057-61. Epub 2015 Mar 26 doi: 10.1016/j.humpath.2015.03.007. PMID: 25953658
Treatment of unicentric Castleman disease with neoadjuvant rituximab.
Bandera B, Ainsworth C, Shikle J, Rupard E, Roach M
Chest 2010 Nov;138(5):1239-41. doi: 10.1378/chest.09-2084. PMID: 21051400
Clinical analysis of Castleman disease (hyaline vascular type) in parotid and neck region.
Zhong LP, Wang LZ, Ji T, Hu YH, Hu YJ, Ye WM, Li J, Sun J, Zhu HG, Li J, Zhang CP
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2010 Mar;109(3):432-40. Epub 2009 Dec 6 doi: 10.1016/j.tripleo.2009.09.025. PMID: 19969478
Cervical Castleman disease in children.
Zhong LP, Chen GF, Zhao SF
Br J Oral Maxillofac Surg 2004 Feb;42(1):69-71. doi: 10.1016/s0266-4356(03)00204-3. PMID: 14706308
Paraneoplastic pemphigus: a case of long-term survival associated with systemic lupus erythematosus and polymyositis.
Mascaró JM Jr, Ferrando J, Solé MT, Alsina M, Nousari HC, Anhalt GJ, Font J, Mascaró JM
Dermatology 1999;199(1):63-6. doi: 10.1159/000018182. PMID: 10449962

Clinical prediction guides

A unicentric center, multicenter, and mixed-type Castleman disease: Three case reports and a review of the literature.
Xu Y, Shao S, Kang H, Xu Z, Wen G, Shan Y, Gong Z, Al-Sharabi A, Qu B, Ren Y, Zhang F, Guan J, Chen X
Medicine (Baltimore) 2024 Apr 12;103(15):e37722. doi: 10.1097/MD.0000000000037722. PMID: 38608101Free PMC Article
Exuberant cortical thymocyte proliferation mimicking T-lymphoblastic lymphoma within recurrent large inguinal lymph node masses of localized Castleman disease.
Kansal R, Nathwani BN, Yiakoumis X, Moschogiannis M, Sachanas S, Stefanaki K, Pangalis GA
Hum Pathol 2015 Jul;46(7):1057-61. Epub 2015 Mar 26 doi: 10.1016/j.humpath.2015.03.007. PMID: 25953658

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