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Castleman disease(ALNH)

MedGen UID:
42211
•Concept ID:
C0017531
•
Disease or Syndrome
Synonyms: ALNH; Angiofollicular lymph hyperplasia; Angiofollicular lymph node hyperplasia; Castleman's disease; Giant Lymph Node Hyperplasia
SNOMED CT: Angiomatous lymphoid hamartoma (207036003); Castleman disease (207036003); Angiofollicular lymph node hyperplasia (207036003); Benign angiofollicular hyperplasia (207036003); Castleman's disease (207036003); Angiolymphoid hyperplasia (207036003); Angiofollicular lymph node hyperplasia (781094002); Giant lymph node hyperplasia (207036003)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0015564
Orphanet: ORPHA160

Definition

A benign lymphoproliferative disorder that may present as a localized or multicentric form. The clinical manifestations are heterogeneous, ranging from asymptomatic discrete lymphadenopathy to recurrent episodes of diffuse lymphadenopathy with severe systemic symptoms. [from ORDO]

Professional guidelines

PubMed

POEMS syndrome: 2021 Update on diagnosis, risk-stratification, and management.
Dispenzieri A
Am J Hematol 2021 Jul 1;96(7):872-888. Epub 2021 May 31 doi: 10.1002/ajh.26240. PMID: 34000085
Polyclonal hypergammaglobulinaemia: assessment, clinical interpretation, and management.
Zhao EJ, Cheng CV, Mattman A, Chen LYC
Lancet Haematol 2021 May;8(5):e365-e375. doi: 10.1016/S2352-3026(21)00056-9. PMID: 33894171
POEMS Syndrome: 2019 Update on diagnosis, risk-stratification, and management.
Dispenzieri A
Am J Hematol 2019 Jul;94(7):812-827. Epub 2019 May 23 doi: 10.1002/ajh.25495. PMID: 31012139

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) B-Cell Lymphomas, 2023

Recent clinical studies

Etiology

Castleman disease.
Carbone A, Borok M, Damania B, Gloghini A, Polizzotto MN, Jayanthan RK, Fajgenbaum DC, Bower M
Nat Rev Dis Primers 2021 Nov 25;7(1):84. doi: 10.1038/s41572-021-00317-7. PMID: 34824298Free PMC Article
Overview of Castleman disease.
Dispenzieri A, Fajgenbaum DC
Blood 2020 Apr 16;135(16):1353-1364. doi: 10.1182/blood.2019000931. PMID: 32106302
Castleman Disease.
Wang W, Medeiros LJ
Surg Pathol Clin 2019 Sep;12(3):849-863. Epub 2019 May 23 doi: 10.1016/j.path.2019.03.003. PMID: 31352991
POEMS Syndrome: 2019 Update on diagnosis, risk-stratification, and management.
Dispenzieri A
Am J Hematol 2019 Jul;94(7):812-827. Epub 2019 May 23 doi: 10.1002/ajh.25495. PMID: 31012139
Idiopathic multicentric Castleman's disease: a systematic literature review.
Liu AY, Nabel CS, Finkelman BS, Ruth JR, Kurzrock R, van Rhee F, Krymskaya VP, Kelleher D, Rubenstein AH, Fajgenbaum DC
Lancet Haematol 2016 Apr;3(4):e163-75. Epub 2016 Mar 17 doi: 10.1016/S2352-3026(16)00006-5. PMID: 27063975

Diagnosis

Idiopathic multicentric Castleman disease and associated autoimmune and autoinflammatory conditions: practical guidance for diagnosis.
González García A, Fernández-Martín J, Robles Marhuenda Á
Rheumatology (Oxford) 2023 Apr 3;62(4):1426-1435. doi: 10.1093/rheumatology/keac481. PMID: 35997567Free PMC Article
Recent Advances in Castleman Disease.
Hoffmann C, Hentrich M, Tiemann M, Rosenwald A, Weber F, Willenbacher W, Hübel K
Oncol Res Treat 2022;45(11):693-704. Epub 2022 Oct 11 doi: 10.1159/000526640. PMID: 36219975
Castleman disease and TAFRO syndrome.
Masaki Y, Arita K, Sakai T, Takai K, Aoki S, Kawabata H
Ann Hematol 2022 Mar;101(3):485-490. Epub 2022 Jan 19 doi: 10.1007/s00277-022-04762-6. PMID: 35044513Free PMC Article
Overview of Castleman disease.
Dispenzieri A, Fajgenbaum DC
Blood 2020 Apr 16;135(16):1353-1364. doi: 10.1182/blood.2019000931. PMID: 32106302
Castleman Disease.
van Rhee F, Munshi NC
Hematol Oncol Clin North Am 2018 Feb;32(1):xiii-xiv. doi: 10.1016/j.hoc.2017.10.001. PMID: 29157623

Therapy

Recent Advances in Castleman Disease.
Hoffmann C, Hentrich M, Tiemann M, Rosenwald A, Weber F, Willenbacher W, Hübel K
Oncol Res Treat 2022;45(11):693-704. Epub 2022 Oct 11 doi: 10.1159/000526640. PMID: 36219975
Castleman disease.
Carbone A, Borok M, Damania B, Gloghini A, Polizzotto MN, Jayanthan RK, Fajgenbaum DC, Bower M
Nat Rev Dis Primers 2021 Nov 25;7(1):84. doi: 10.1038/s41572-021-00317-7. PMID: 34824298Free PMC Article
Overview of Castleman disease.
Dispenzieri A, Fajgenbaum DC
Blood 2020 Apr 16;135(16):1353-1364. doi: 10.1182/blood.2019000931. PMID: 32106302
POEMS Syndrome: 2019 Update on diagnosis, risk-stratification, and management.
Dispenzieri A
Am J Hematol 2019 Jul;94(7):812-827. Epub 2019 May 23 doi: 10.1002/ajh.25495. PMID: 31012139
Interleukin (IL-6) Immunotherapy.
Tanaka T, Narazaki M, Kishimoto T
Cold Spring Harb Perspect Biol 2018 Aug 1;10(8) doi: 10.1101/cshperspect.a028456. PMID: 28778870Free PMC Article

Prognosis

Castleman disease.
Carbone A, Borok M, Damania B, Gloghini A, Polizzotto MN, Jayanthan RK, Fajgenbaum DC, Bower M
Nat Rev Dis Primers 2021 Nov 25;7(1):84. doi: 10.1038/s41572-021-00317-7. PMID: 34824298Free PMC Article
Castleman Disease.
Wang W, Medeiros LJ
Surg Pathol Clin 2019 Sep;12(3):849-863. Epub 2019 May 23 doi: 10.1016/j.path.2019.03.003. PMID: 31352991
TAFRO Syndrome.
Igawa T, Sato Y
Hematol Oncol Clin North Am 2018 Feb;32(1):107-118. doi: 10.1016/j.hoc.2017.09.009. PMID: 29157612
Lymphoproliferative Disorders of the Lung.
Borie R, Wislez M, Antoine M, Cadranel J
Respiration 2017;94(2):157-175. Epub 2017 Jun 14 doi: 10.1159/000477740. PMID: 28609772
Siltuximab for multicentric Castleman's disease: a randomised, double-blind, placebo-controlled trial.
van Rhee F, Wong RS, Munshi N, Rossi JF, Ke XY, Fosså A, Simpson D, Capra M, Liu T, Hsieh RK, Goh YT, Zhu J, Cho SG, Ren H, Cavet J, Bandekar R, Rothman M, Puchalski TA, Reddy M, van de Velde H, Vermeulen J, Casper C
Lancet Oncol 2014 Aug;15(9):966-74. Epub 2014 Jul 17 doi: 10.1016/S1470-2045(14)70319-5. PMID: 25042199

Clinical prediction guides

CXCL13 is a predictive biomarker in idiopathic multicentric Castleman disease.
Pierson SK, Katz L, Williams R, Mumau M, Gonzalez M, Guzman S, Rubenstein A, Oromendia AB, Beineke P, Fosså A, van Rhee F, Fajgenbaum DC
Nat Commun 2022 Nov 24;13(1):7236. doi: 10.1038/s41467-022-34873-7. PMID: 36433996Free PMC Article
Clinical characteristics and immunological abnormalities of Castleman disease complicated with autoimmune diseases.
Sun DP, Chen WM, Wang L, Wang Z, Liang JH, Zhu HY, Fan L, Wu YJ, Xu W, Li JY
J Cancer Res Clin Oncol 2021 Jul;147(7):2107-2115. Epub 2021 Feb 5 doi: 10.1007/s00432-020-03494-2. PMID: 33544201Free PMC Article
International evidence-based consensus diagnostic and treatment guidelines for unicentric Castleman disease.
van Rhee F, Oksenhendler E, Srkalovic G, Voorhees P, Lim M, Dispenzieri A, Ide M, Parente S, Schey S, Streetly M, Wong R, Wu D, Maillard I, Brandstadter J, Munshi N, Bowne W, Elenitoba-Johnson KS, Fössa A, Lechowicz MJ, Chandrakasan S, Pierson SK, Greenway A, Nasta S, Yoshizaki K, Kurzrock R, Uldrick TS, Casper C, Chadburn A, Fajgenbaum DC
Blood Adv 2020 Dec 8;4(23):6039-6050. doi: 10.1182/bloodadvances.2020003334. PMID: 33284946Free PMC Article
Imaging and clinical features of Castleman Disease.
Zhao S, Wan Y, Huang Z, Song B, Yu J
Cancer Imaging 2019 Jul 25;19(1):53. doi: 10.1186/s40644-019-0238-0. PMID: 31345268Free PMC Article
Idiopathic multicentric Castleman's disease: a systematic literature review.
Liu AY, Nabel CS, Finkelman BS, Ruth JR, Kurzrock R, van Rhee F, Krymskaya VP, Kelleher D, Rubenstein AH, Fajgenbaum DC
Lancet Haematol 2016 Apr;3(4):e163-75. Epub 2016 Mar 17 doi: 10.1016/S2352-3026(16)00006-5. PMID: 27063975

Recent systematic reviews

TAFRO syndrome: A severe manifestation of Sjogren's syndrome? A systematic review.
Grange L, Chalayer E, Boutboul D, Paul S, Galicier L, Gramont B, Killian M
Autoimmun Rev 2022 Aug;21(8):103137. Epub 2022 Jul 6 doi: 10.1016/j.autrev.2022.103137. PMID: 35803499
Efficacy and safety of regimens used for the treatment of multicentric Castleman disease: A systematic review.
Rehman MEU, Chattaraj A, Neupane K, Rafae A, Saeed S, Basit J, Ibrahim A, Khouri J, Mukherjee S, Anwer F
Eur J Haematol 2022 Oct;109(4):309-320. Epub 2022 Jul 13 doi: 10.1111/ejh.13823. PMID: 35770616
The role of surgical resection in Unicentric Castleman's disease: a systematic review.
Mitsos S, Stamatopoulos A, Patrini D, George RS, Lawrence DR, Panagiotopoulos N
Adv Respir Med 2018;86(1):36-43. doi: 10.5603/ARM.2018.0008. PMID: 29490420
Idiopathic multicentric Castleman's disease: a systematic literature review.
Liu AY, Nabel CS, Finkelman BS, Ruth JR, Kurzrock R, van Rhee F, Krymskaya VP, Kelleher D, Rubenstein AH, Fajgenbaum DC
Lancet Haematol 2016 Apr;3(4):e163-75. Epub 2016 Mar 17 doi: 10.1016/S2352-3026(16)00006-5. PMID: 27063975
Surgery in Castleman's disease: a systematic review of 404 published cases.
Talat N, Belgaumkar AP, Schulte KM
Ann Surg 2012 Apr;255(4):677-84. doi: 10.1097/SLA.0b013e318249dcdc. PMID: 22367441

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    Curated

    • NCCN, 2023
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) B-Cell Lymphomas, 2023

    Reviews

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