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Grade 2 Clear Cell Renal Cell Carcinoma

MedGen UID:
232560
Concept ID:
C1333835
Neoplastic Process
Synonym: Grade 2 Conventional (Clear Cell) Renal Cell Carcinoma

Definition

A clear cell renal cell carcinoma characterized by nucleoli conspicuous and eosinophilic at x 400 magnification, and visible but not prominent at x 100 magnification. (WHO 1982 /ISUP 2014) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGrade 2 Clear Cell Renal Cell Carcinoma

Professional guidelines

PubMed

Trpkov K, Williamson SR, Gill AJ, Adeniran AJ, Agaimy A, Alaghehbandan R, Amin MB, Argani P, Chen YB, Cheng L, Epstein JI, Cheville JC, Comperat E, da Cunha IW, Gordetsky JB, Gupta S, He H, Hirsch MS, Humphrey PA, Kapur P, Kojima F, Lopez JI, Maclean F, Magi-Galluzzi C, McKenney JK, Mehra R, Menon S, Netto GJ, Przybycin CG, Rao P, Rao Q, Reuter VE, Saleeb RM, Shah RB, Smith SC, Tickoo S, Tretiakova MS, True L, Verkarre V, Wobker SE, Zhou M, Hes O
Mod Pathol 2021 Jun;34(6):1167-1184. Epub 2021 Feb 1 doi: 10.1038/s41379-021-00737-6. PMID: 33526874
Smith BW, Joseph JR, Saadeh YS, La Marca F, Szerlip NJ, Schermerhorn TC, Spratt DE, Younge KC, Park P
World Neurosurg 2018 Jan;109:e502-e509. Epub 2017 Oct 13 doi: 10.1016/j.wneu.2017.10.011. PMID: 29038086
Pick AM, Nystrom KK
Clin Ther 2012 Mar;34(3):511-20. Epub 2012 Feb 16 doi: 10.1016/j.clinthera.2012.01.014. PMID: 22341567

Recent clinical studies

Etiology

Gui CP, Chen YH, Zhao HW, Cao JZ, Liu TJ, Xiong SW, Yu YF, Liao B, Cao Y, Li JY, Huang KB, Han H, Zhang ZL, Chen WF, Jiang ZY, Gao Y, Han GP, Tang Q, Ouyang K, Qu GM, Wu JT, Guo JP, Li CX, Li PX, Liu ZP, Hsieh JT, Cai MY, Li XS, Wei JH, Luo JH
Lancet Digit Health 2023 Aug;5(8):e515-e524. Epub 2023 Jun 29 doi: 10.1016/S2589-7500(23)00095-X. PMID: 37393162
Choueiri TK, McDermott DF, Merchan J, Bauer TM, Figlin R, Heath EI, Michaelson MD, Arrowsmith E, D'Souza A, Zhao S, Roy A, Perini R, Vickery D, Tykodi SS
Lancet Oncol 2023 May;24(5):553-562. Epub 2023 Mar 31 doi: 10.1016/S1470-2045(23)00097-9. PMID: 37011650
Mohanty SK, Lobo A, Cheng L
Hum Pathol 2023 Jun;136:123-143. Epub 2022 Sep 6 doi: 10.1016/j.humpath.2022.08.006. PMID: 36084769
Ravaud A, Motzer RJ, Pandha HS, George DJ, Pantuck AJ, Patel A, Chang YH, Escudier B, Donskov F, Magheli A, Carteni G, Laguerre B, Tomczak P, Breza J, Gerletti P, Lechuga M, Lin X, Martini JF, Ramaswamy K, Casey M, Staehler M, Patard JJ; S-TRAC Investigators
N Engl J Med 2016 Dec 8;375(23):2246-2254. Epub 2016 Oct 9 doi: 10.1056/NEJMoa1611406. PMID: 27718781
Motzer RJ, Hutson TE, Glen H, Michaelson MD, Molina A, Eisen T, Jassem J, Zolnierek J, Maroto JP, Mellado B, Melichar B, Tomasek J, Kremer A, Kim HJ, Wood K, Dutcus C, Larkin J
Lancet Oncol 2015 Nov;16(15):1473-1482. Epub 2015 Oct 22 doi: 10.1016/S1470-2045(15)00290-9. PMID: 26482279

Diagnosis

Gui CP, Chen YH, Zhao HW, Cao JZ, Liu TJ, Xiong SW, Yu YF, Liao B, Cao Y, Li JY, Huang KB, Han H, Zhang ZL, Chen WF, Jiang ZY, Gao Y, Han GP, Tang Q, Ouyang K, Qu GM, Wu JT, Guo JP, Li CX, Li PX, Liu ZP, Hsieh JT, Cai MY, Li XS, Wei JH, Luo JH
Lancet Digit Health 2023 Aug;5(8):e515-e524. Epub 2023 Jun 29 doi: 10.1016/S2589-7500(23)00095-X. PMID: 37393162
Rupert K, Kural T, Skalický T, Zeithaml J, Hess O, Třeška V
Rozhl Chir 2020 Summer;99(7):311-315. doi: 10.33699/PIS.2020.99.7.311-315. PMID: 32972149
Tian K, Rubadue CA, Lin DI, Veta M, Pyle ME, Irshad H, Heng YJ
PLoS One 2019;14(10):e0222641. Epub 2019 Oct 3 doi: 10.1371/journal.pone.0222641. PMID: 31581201Free PMC Article
Delahunt B, Egevad L, Samaratunga H, Martignoni G, Nacey JN, Srigley JR
Histopathology 2016 Mar;68(4):475-81. Epub 2015 Nov 16 doi: 10.1111/his.12803. PMID: 26266664
Delahunt B, Cheville JC, Martignoni G, Humphrey PA, Magi-Galluzzi C, McKenney J, Egevad L, Algaba F, Moch H, Grignon DJ, Montironi R, Srigley JR; Members of the ISUP Renal Tumor Panel
Am J Surg Pathol 2013 Oct;37(10):1490-504. doi: 10.1097/PAS.0b013e318299f0fb. PMID: 24025520

Therapy

Choueiri TK, Powles T, Albiges L, Burotto M, Szczylik C, Zurawski B, Yanez Ruiz E, Maruzzo M, Suarez Zaizar A, Fein LE, Schutz FA, Heng DYC, Wang F, Mataveli F, Chang YL, van Kooten Losio M, Suarez C, Motzer RJ; COSMIC-313 Investigators
N Engl J Med 2023 May 11;388(19):1767-1778. doi: 10.1056/NEJMoa2212851. PMID: 37163623Free PMC Article
Powles T, Tomczak P, Park SH, Venugopal B, Ferguson T, Symeonides SN, Hajek J, Gurney H, Chang YH, Lee JL, Sarwar N, Thiery-Vuillemin A, Gross-Goupil M, Mahave M, Haas NB, Sawrycki P, Burgents JE, Xu L, Imai K, Quinn DI, Choueiri TK; KEYNOTE-564 Investigators
Lancet Oncol 2022 Sep;23(9):1133-1144. doi: 10.1016/S1470-2045(22)00487-9. PMID: 36055304
Motzer RJ, Powles T, Burotto M, Escudier B, Bourlon MT, Shah AY, Suárez C, Hamzaj A, Porta C, Hocking CM, Kessler ER, Gurney H, Tomita Y, Bedke J, Zhang J, Simsek B, Scheffold C, Apolo AB, Choueiri TK
Lancet Oncol 2022 Jul;23(7):888-898. Epub 2022 Jun 7 doi: 10.1016/S1470-2045(22)00290-X. PMID: 35688173Free PMC Article
Choueiri TK, Powles T, Burotto M, Escudier B, Bourlon MT, Zurawski B, Oyervides Juárez VM, Hsieh JJ, Basso U, Shah AY, Suárez C, Hamzaj A, Goh JC, Barrios C, Richardet M, Porta C, Kowalyszyn R, Feregrino JP, Żołnierek J, Pook D, Kessler ER, Tomita Y, Mizuno R, Bedke J, Zhang J, Maurer MA, Simsek B, Ejzykowicz F, Schwab GM, Apolo AB, Motzer RJ; CheckMate 9ER Investigators
N Engl J Med 2021 Mar 4;384(9):829-841. doi: 10.1056/NEJMoa2026982. PMID: 33657295Free PMC Article
Motzer RJ, Tannir NM, McDermott DF, Arén Frontera O, Melichar B, Choueiri TK, Plimack ER, Barthélémy P, Porta C, George S, Powles T, Donskov F, Neiman V, Kollmannsberger CK, Salman P, Gurney H, Hawkins R, Ravaud A, Grimm MO, Bracarda S, Barrios CH, Tomita Y, Castellano D, Rini BI, Chen AC, Mekan S, McHenry MB, Wind-Rotolo M, Doan J, Sharma P, Hammers HJ, Escudier B; CheckMate 214 Investigators
N Engl J Med 2018 Apr 5;378(14):1277-1290. Epub 2018 Mar 21 doi: 10.1056/NEJMoa1712126. PMID: 29562145Free PMC Article

Prognosis

Liu DH, Dani KA, Reddy SS, Lei X, Demirjian NL, Hwang DH, Varghese BA, Rhie SK, Yap FY, Quinn DI, Siddiqi I, Aron M, Vaishampayan U, Zahoor H, Cen SY, Gill IS, Duddalwar VA
Oncology 2023;101(6):375-388. Epub 2023 Apr 20 doi: 10.1159/000530719. PMID: 37080171
Powles T, Tomczak P, Park SH, Venugopal B, Ferguson T, Symeonides SN, Hajek J, Gurney H, Chang YH, Lee JL, Sarwar N, Thiery-Vuillemin A, Gross-Goupil M, Mahave M, Haas NB, Sawrycki P, Burgents JE, Xu L, Imai K, Quinn DI, Choueiri TK; KEYNOTE-564 Investigators
Lancet Oncol 2022 Sep;23(9):1133-1144. doi: 10.1016/S1470-2045(22)00487-9. PMID: 36055304
Motzer RJ, Powles T, Burotto M, Escudier B, Bourlon MT, Shah AY, Suárez C, Hamzaj A, Porta C, Hocking CM, Kessler ER, Gurney H, Tomita Y, Bedke J, Zhang J, Simsek B, Scheffold C, Apolo AB, Choueiri TK
Lancet Oncol 2022 Jul;23(7):888-898. Epub 2022 Jun 7 doi: 10.1016/S1470-2045(22)00290-X. PMID: 35688173Free PMC Article
Choueiri TK, Escudier B, Powles T, Tannir NM, Mainwaring PN, Rini BI, Hammers HJ, Donskov F, Roth BJ, Peltola K, Lee JL, Heng DYC, Schmidinger M, Agarwal N, Sternberg CN, McDermott DF, Aftab DT, Hessel C, Scheffold C, Schwab G, Hutson TE, Pal S, Motzer RJ; METEOR investigators
Lancet Oncol 2016 Jul;17(7):917-927. Epub 2016 Jun 5 doi: 10.1016/S1470-2045(16)30107-3. PMID: 27279544
Delahunt B, Cheville JC, Martignoni G, Humphrey PA, Magi-Galluzzi C, McKenney J, Egevad L, Algaba F, Moch H, Grignon DJ, Montironi R, Srigley JR; Members of the ISUP Renal Tumor Panel
Am J Surg Pathol 2013 Oct;37(10):1490-504. doi: 10.1097/PAS.0b013e318299f0fb. PMID: 24025520

Clinical prediction guides

Gui CP, Chen YH, Zhao HW, Cao JZ, Liu TJ, Xiong SW, Yu YF, Liao B, Cao Y, Li JY, Huang KB, Han H, Zhang ZL, Chen WF, Jiang ZY, Gao Y, Han GP, Tang Q, Ouyang K, Qu GM, Wu JT, Guo JP, Li CX, Li PX, Liu ZP, Hsieh JT, Cai MY, Li XS, Wei JH, Luo JH
Lancet Digit Health 2023 Aug;5(8):e515-e524. Epub 2023 Jun 29 doi: 10.1016/S2589-7500(23)00095-X. PMID: 37393162
Liu DH, Dani KA, Reddy SS, Lei X, Demirjian NL, Hwang DH, Varghese BA, Rhie SK, Yap FY, Quinn DI, Siddiqi I, Aron M, Vaishampayan U, Zahoor H, Cen SY, Gill IS, Duddalwar VA
Oncology 2023;101(6):375-388. Epub 2023 Apr 20 doi: 10.1159/000530719. PMID: 37080171
Lee CH, Voss MH, Carlo MI, Chen YB, Zucker M, Knezevic A, Lefkowitz RA, Shapnik N, Dadoun C, Reznik E, Shah NJ, Owens CN, McHugh DJ, Aggen DH, Laccetti AL, Kotecha R, Feldman DR, Motzer RJ
J Clin Oncol 2022 Jul 20;40(21):2333-2341. Epub 2022 Mar 17 doi: 10.1200/JCO.21.01944. PMID: 35298296Free PMC Article
Delahunt B, Egevad L, Samaratunga H, Martignoni G, Nacey JN, Srigley JR
Histopathology 2016 Mar;68(4):475-81. Epub 2015 Nov 16 doi: 10.1111/his.12803. PMID: 26266664
Lohse CM, Gupta S, Cheville JC
Semin Diagn Pathol 2015 Mar;32(2):172-83. Epub 2015 Feb 7 doi: 10.1053/j.semdp.2015.02.008. PMID: 25753528

Recent systematic reviews

Riveros C, Huang E, Ranganathan S, Klaassen Z, Rini B, Wallis CJD, Satkunasivam R
BJU Int 2023 May;131(5):553-561. Epub 2023 Feb 28 doi: 10.1111/bju.15981. PMID: 36709462
Wu Z, Chen Q, Qu L, Li M, Wang L, Mir MC, Carbonara U, Pandolfo SD, Black PC, Paul AK, Di Lorenzo G, Porpiglia F, Mari A, Necchi A, Rouprêt M, Psutka SP, Autorino R
Eur Urol 2022 Apr;81(4):414-425. Epub 2022 Jan 31 doi: 10.1016/j.eururo.2022.01.028. PMID: 35101302
Hussaini S, Chehade R, Boldt RG, Raphael J, Blanchette P, Maleki Vareki S, Fernandes R
Cancer Treat Rev 2021 Jan;92:102134. Epub 2020 Dec 3 doi: 10.1016/j.ctrv.2020.102134. PMID: 33302134
Khoja L, Day D, Wei-Wu Chen T, Siu LL, Hansen AR
Ann Oncol 2017 Oct 1;28(10):2377-2385. doi: 10.1093/annonc/mdx286. PMID: 28945858
Pierorazio PM, Johnson MH, Patel HD, Sozio SM, Sharma R, Iyoha E, Bass EB, Allaf ME
J Urol 2016 Oct;196(4):989-99. Epub 2016 May 6 doi: 10.1016/j.juro.2016.04.081. PMID: 27157369Free PMC Article

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