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Hemihypertrophy of lower limb

MedGen UID:
451056
•Concept ID:
C0431928
•
Congenital Abnormality
Synonyms: Congenital overgrowth of lower limb; Overgrowth of one leg
SNOMED CT: Congenital overgrowth of lower limb (205369009); Hemihypertrophy of lower limb (205369009)
 
HPO: HP:0100553

Definition

Overgrowth of only one leg. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHemihypertrophy of lower limb

Professional guidelines

PubMed

Differential diagnosis of lower extremity enlargement in pediatric patients referred with a diagnosis of lymphedema.
Schook CC, Mulliken JB, Fishman SJ, Alomari AI, Grant FD, Greene AK
Plast Reconstr Surg 2011 Apr;127(4):1571-1581. doi: 10.1097/PRS.0b013e31820a64f3. PMID: 21187804
Vascular abnormalities of the extremities: clinical findings and management.
Rogalski R, Hensinger R, Loder R
J Pediatr Orthop 1993 Jan-Feb;13(1):9-14. doi: 10.1097/01241398-199301000-00003. PMID: 8416363

Recent clinical studies

Etiology

Fifteen-minute consultation: Assessment, surveillance and management of hemihypertrophy.
Mark C, Hart C, McCarthy A, Thompson A
Arch Dis Child Educ Pract Ed 2018 Jun;103(3):114-117. Epub 2017 Aug 26 doi: 10.1136/archdischild-2017-312645. PMID: 28844056
Axial and appendicular body proportions for evaluation of limb and trunk asymmetry.
Weinberg DS, Liu RW, Li SQ, Sanders JO, Cooperman DR
Acta Orthop 2017 Apr;88(2):185-191. Epub 2016 Dec 21 doi: 10.1080/17453674.2016.1265876. PMID: 27998211Free PMC Article
Idiopathic hemihypertrophy.
Mohanna MA, Sallam AK
Saudi Med J 2014 Apr;35(4):403-5. PMID: 24749139
Differential diagnosis of lower extremity enlargement in pediatric patients referred with a diagnosis of lymphedema.
Schook CC, Mulliken JB, Fishman SJ, Alomari AI, Grant FD, Greene AK
Plast Reconstr Surg 2011 Apr;127(4):1571-1581. doi: 10.1097/PRS.0b013e31820a64f3. PMID: 21187804
Efficacy and safety of percutaneous epiphysiodesis.
Inan M, Chan G, Littleton AG, Kubiak P, Bowen JR
J Pediatr Orthop 2008 Sep;28(6):648-51. doi: 10.1097/BPO.0b013e3181832475. PMID: 18724201

Diagnosis

Idiopathic hemihypertrophy.
Mohanna MA, Sallam AK
Saudi Med J 2014 Apr;35(4):403-5. PMID: 24749139
Differential diagnosis of lower extremity enlargement in pediatric patients referred with a diagnosis of lymphedema.
Schook CC, Mulliken JB, Fishman SJ, Alomari AI, Grant FD, Greene AK
Plast Reconstr Surg 2011 Apr;127(4):1571-1581. doi: 10.1097/PRS.0b013e31820a64f3. PMID: 21187804
Hemihypertrophy. Concepts and controversies.
Ballock RT, Wiesner GL, Myers MT, Thompson GH
J Bone Joint Surg Am 1997 Nov;79(11):1731-8. doi: 10.2106/00004623-199711000-00016. PMID: 9384434
Proteus syndrome.
Darmstadt GL, Lane AT
Pediatr Dermatol 1994 Sep;11(3):222-6. doi: 10.1111/j.1525-1470.1994.tb00590.x. PMID: 7971556
Proteus syndrome.
Samlaska CP, Levin SW, James WD, Benson PM, Walker JC, Perlik PC
Arch Dermatol 1989 Aug;125(8):1109-14. PMID: 2667470

Therapy

Fifteen-minute consultation: Assessment, surveillance and management of hemihypertrophy.
Mark C, Hart C, McCarthy A, Thompson A
Arch Dis Child Educ Pract Ed 2018 Jun;103(3):114-117. Epub 2017 Aug 26 doi: 10.1136/archdischild-2017-312645. PMID: 28844056
Efficacy and safety of percutaneous epiphysiodesis.
Inan M, Chan G, Littleton AG, Kubiak P, Bowen JR
J Pediatr Orthop 2008 Sep;28(6):648-51. doi: 10.1097/BPO.0b013e3181832475. PMID: 18724201
Severe growth retardation following limb lengthening: a case report.
Price CT, Carantzas AC
Iowa Orthop J 1996;16:139-46. PMID: 9129286Free PMC Article

Prognosis

Axial and appendicular body proportions for evaluation of limb and trunk asymmetry.
Weinberg DS, Liu RW, Li SQ, Sanders JO, Cooperman DR
Acta Orthop 2017 Apr;88(2):185-191. Epub 2016 Dec 21 doi: 10.1080/17453674.2016.1265876. PMID: 27998211Free PMC Article
Efficacy and safety of percutaneous epiphysiodesis.
Inan M, Chan G, Littleton AG, Kubiak P, Bowen JR
J Pediatr Orthop 2008 Sep;28(6):648-51. doi: 10.1097/BPO.0b013e3181832475. PMID: 18724201
Congenital hemihypertrophy with hemihypertrichosis.
Akarsu S, Coskun BK, Aydin AM, Tekatli M, Aygun AD
J Dermatol 2005 Jun;32(6):478-81. doi: 10.1111/j.1346-8138.2005.tb00784.x. PMID: 16043924
Hemihypertrophy and a poorly differentiated embryonal rhabdomyosarcoma of the pelvis.
Samuel DP, Tsokos M, DeBaun MR
Med Pediatr Oncol 1999 Jan;32(1):38-43. doi: 10.1002/(sici)1096-911x(199901)32:1<38::aid-mpo8>3.0.co;2-h. PMID: 9917751
Vascular abnormalities of the extremities: clinical findings and management.
Rogalski R, Hensinger R, Loder R
J Pediatr Orthop 1993 Jan-Feb;13(1):9-14. doi: 10.1097/01241398-199301000-00003. PMID: 8416363

Clinical prediction guides

Clinical Phenotype and Bone Biopsy Characteristics in a Child with Proteus Syndrome.
Al Kaissi A, Misof BM, Laccone F, Blouin S, Roschger P, Kircher SG, Shboul M, Mindler GT, Girsch W, Ganger R
Calcif Tissue Int 2021 Nov;109(5):586-595. Epub 2021 May 18 doi: 10.1007/s00223-021-00862-z. PMID: 34003338
Axial and appendicular body proportions for evaluation of limb and trunk asymmetry.
Weinberg DS, Liu RW, Li SQ, Sanders JO, Cooperman DR
Acta Orthop 2017 Apr;88(2):185-191. Epub 2016 Dec 21 doi: 10.1080/17453674.2016.1265876. PMID: 27998211Free PMC Article
Efficacy and safety of percutaneous epiphysiodesis.
Inan M, Chan G, Littleton AG, Kubiak P, Bowen JR
J Pediatr Orthop 2008 Sep;28(6):648-51. doi: 10.1097/BPO.0b013e3181832475. PMID: 18724201
Proteus syndrome.
Yasuda H, Yamamoto O, Hirokawa H, Asahi M, Kashimura M, Sakai A
Dermatology 2001;203(2):180-4. doi: 10.1159/000051739. PMID: 11586023
Vascular abnormalities of the extremities: clinical findings and management.
Rogalski R, Hensinger R, Loder R
J Pediatr Orthop 1993 Jan-Feb;13(1):9-14. doi: 10.1097/01241398-199301000-00003. PMID: 8416363

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