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Localized Castleman disease

MedGen UID:
858176
•Concept ID:
C3898582
•
Disease or Syndrome
Synonyms: localised Angiofollicular lymphoid hyperplasia; Localized Angiofollicular Lymphoid Hyperplasia; localized Angiofollicular lymphoid hyperplasia; Localized Castleman Disease; localized Castleman disease; Unicentric angiofollicular ganglionic hyperplasia; Unicentric angiofollicular lymph hyperplasia; Unicentric Castleman disease
SNOMED CT: Localized Castleman disease (1156784009)
 
Monarch Initiative: MONDO:0019753
Orphanet: ORPHA93685

Definition

A form of Castleman disease that is usually asymptomatic or that may present with enlarged lymph nodes. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLocalized Castleman disease

Professional guidelines

PubMed

Diagnosis and management of neuropathies associated with plasma cell dyscrasias.
Rosenbaum E, Marks D, Raza S
Hematol Oncol 2018 Feb;36(1):3-14. Epub 2017 Apr 10 doi: 10.1002/hon.2417. PMID: 28397326
POEMS syndrome: update on diagnosis, risk-stratification, and management.
Dispenzieri A
Am J Hematol 2015 Oct;90(10):951-62. Epub 2015 Sep 1 doi: 10.1002/ajh.24171. PMID: 26331353
Diagnosis and management of Castleman disease.
Soumerai JD, Sohani AR, Abramson JS
Cancer Control 2014 Oct;21(4):266-78. doi: 10.1177/107327481402100403. PMID: 25310208

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Castleman Disease, 2024

Recent clinical studies

Etiology

Sonographic findings of localized Castleman disease of the abdomen and pelvis.
Zhou W, Zhan W, Zhou J, Zhu Y, Yao J
J Clin Ultrasound 2015 Sep;43(7):401-5. Epub 2014 Oct 27 doi: 10.1002/jcu.22245. PMID: 25346169
Castleman disease of the thorax: radiologic features with clinical and histopathologic correlation.
McAdams HP, Rosado-de-Christenson M, Fishback NF, Templeton PA
Radiology 1998 Oct;209(1):221-8. doi: 10.1148/radiology.209.1.9769835. PMID: 9769835

Diagnosis

Radiologic and Histopathologic Features in an Intracranial Localized Castleman Disease: A Case Report and Review of Literature.
Escribano Paredes JB, Carrasco Moro R, López Gutiérrez M, Arias HP, García-Cosío M, García Madrona S, Nedkova Hristova V, Martínez Poles J, Francisco JBC
Neurologist 2019 Jan;24(1):33-36. doi: 10.1097/NRL.0000000000000203. PMID: 30586033
Exuberant cortical thymocyte proliferation mimicking T-lymphoblastic lymphoma within recurrent large inguinal lymph node masses of localized Castleman disease.
Kansal R, Nathwani BN, Yiakoumis X, Moschogiannis M, Sachanas S, Stefanaki K, Pangalis GA
Hum Pathol 2015 Jul;46(7):1057-61. Epub 2015 Mar 26 doi: 10.1016/j.humpath.2015.03.007. PMID: 25953658
Sonographic findings of localized Castleman disease of the abdomen and pelvis.
Zhou W, Zhan W, Zhou J, Zhu Y, Yao J
J Clin Ultrasound 2015 Sep;43(7):401-5. Epub 2014 Oct 27 doi: 10.1002/jcu.22245. PMID: 25346169
Localized Castleman disease of plasma cell type in the abdomen.
Lu ZH, Wu M
Chin Med J (Engl) 2011 Sep;124(17):2789-91. PMID: 22040445
Localized Castleman disease in retroperitoneum: newly discovered features by multi-detector helical CT.
Zheng X, Pan K, Cheng J, Dong L, Yang K, Wu E
Abdom Imaging 2008 Jul-Aug;33(4):489-92. doi: 10.1007/s00261-007-9273-6. PMID: 17619097

Therapy

Multicentric Castleman disease with secondary AA renal amyloidosis, nephrotic syndrome and chronic renal failure, remission after high-dose melphalan and autologous stem cell transplantation.
Ogita M, Hoshino J, Sogawa Y, Sawa N, Katori H, Takemoto F, Ubara Y, Hara S, Miyakoshi S, Takaichi K
Clin Nephrol 2007 Sep;68(3):171-6. doi: 10.5414/cnp68171. PMID: 17915620

Prognosis

Radiologic and Histopathologic Features in an Intracranial Localized Castleman Disease: A Case Report and Review of Literature.
Escribano Paredes JB, Carrasco Moro R, López Gutiérrez M, Arias HP, García-Cosío M, García Madrona S, Nedkova Hristova V, Martínez Poles J, Francisco JBC
Neurologist 2019 Jan;24(1):33-36. doi: 10.1097/NRL.0000000000000203. PMID: 30586033
Exuberant cortical thymocyte proliferation mimicking T-lymphoblastic lymphoma within recurrent large inguinal lymph node masses of localized Castleman disease.
Kansal R, Nathwani BN, Yiakoumis X, Moschogiannis M, Sachanas S, Stefanaki K, Pangalis GA
Hum Pathol 2015 Jul;46(7):1057-61. Epub 2015 Mar 26 doi: 10.1016/j.humpath.2015.03.007. PMID: 25953658
Human herpesvirus 8 and Epstein-Barr virus coinfection in localized Castleman disease during pregnancy.
Hernández JL, Gómez-Román J, Ramos-Estébanez C, Nan D, Martín-Oviedo J, Riancho JA, González-Macías J
Haematologica 2005 Nov;90 Suppl:ECR35. PMID: 16266926

Clinical prediction guides

Exuberant cortical thymocyte proliferation mimicking T-lymphoblastic lymphoma within recurrent large inguinal lymph node masses of localized Castleman disease.
Kansal R, Nathwani BN, Yiakoumis X, Moschogiannis M, Sachanas S, Stefanaki K, Pangalis GA
Hum Pathol 2015 Jul;46(7):1057-61. Epub 2015 Mar 26 doi: 10.1016/j.humpath.2015.03.007. PMID: 25953658
Castleman disease of the thorax: radiologic features with clinical and histopathologic correlation.
McAdams HP, Rosado-de-Christenson M, Fishback NF, Templeton PA
Radiology 1998 Oct;209(1):221-8. doi: 10.1148/radiology.209.1.9769835. PMID: 9769835

Supplemental Content

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    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NCCN, 2024
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Castleman Disease, 2024

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

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