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Vulva cancer

MedGen UID:
91196
•Concept ID:
C0375071
•
Neoplastic Process
Synonyms: Cancer of the Vulva; Cancer of Vulva; Cancer, Vulva; Cancer, Vulvar; Cancers, Vulva; Cancers, Vulvar; Vulva Cancer; Vulva Cancers; Vulvar Cancer; Vulvar Cancers
SNOMED CT: Cancer of vulva (363367000); Malignant tumor of vulva (363367000)
 
Monarch Initiative: MONDO:0001528

Definition

A primary or metastatic malignant neoplasm involving the vulva. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVVulva cancer

Professional guidelines

PubMed

Sexual and Psychosexual Consequences of Treatment for Gynaecological Cancers.
Rizzuto I, Oehler MK, Lalondrelle S
Clin Oncol (R Coll Radiol) 2021 Sep;33(9):602-607. Epub 2021 Jul 17 doi: 10.1016/j.clon.2021.07.003. PMID: 34281725
Cold Atmospheric Pressure Plasma (CAP) as a New Tool for the Management of Vulva Cancer and Vulvar Premalignant Lesions in Gynaecological Oncology.
Zubor P, Wang Y, Liskova A, Samec M, Koklesova L, Dankova Z, Dørum A, Kajo K, Dvorska D, Lucansky V, Malicherova B, Kasubova I, Bujnak J, Mlyncek M, Dussan CA, Kubatka P, Büsselberg D, Golubnitschaja O
Int J Mol Sci 2020 Oct 27;21(21) doi: 10.3390/ijms21217988. PMID: 33121141Free PMC Article
Chemotherapy and radiation therapy in the treatment of squamous cell carcinoma of the vulva: Are two therapies better than one?
Moore DH
Gynecol Oncol 2009 Jun;113(3):379-83. Epub 2009 Feb 20 doi: 10.1016/j.ygyno.2009.01.004. PMID: 19232700

Recent clinical studies

Etiology

Burden of HPV-Related Hospitalization in Germany from 2000 to 2021.
Tampakoudis G, Anastasiou OE
Viruses 2023 Aug 31;15(9) doi: 10.3390/v15091857. PMID: 37766265Free PMC Article
Comorbidity in patients with Lichen sclerosus: a retrospective cohort study.
Gulin SJ, Lundin F, Seifert O
Eur J Med Res 2023 Sep 11;28(1):338. doi: 10.1186/s40001-023-01335-9. PMID: 37697418Free PMC Article
Mapping evidence on ovarian, endometrial, vaginal, and vulva cancer research in Africa: a scoping review protocol.
Ninimiya SY, Ansu-Mensah M, Bawontuo V, Kuupiel D
Syst Rev 2021 Apr 14;10(1):108. doi: 10.1186/s13643-021-01654-0. PMID: 33849664Free PMC Article
Cold Atmospheric Pressure Plasma (CAP) as a New Tool for the Management of Vulva Cancer and Vulvar Premalignant Lesions in Gynaecological Oncology.
Zubor P, Wang Y, Liskova A, Samec M, Koklesova L, Dankova Z, Dørum A, Kajo K, Dvorska D, Lucansky V, Malicherova B, Kasubova I, Bujnak J, Mlyncek M, Dussan CA, Kubatka P, Büsselberg D, Golubnitschaja O
Int J Mol Sci 2020 Oct 27;21(21) doi: 10.3390/ijms21217988. PMID: 33121141Free PMC Article
Locally advanced vulva cancer: A single centre review of anovulvectomy and a systematic review of surgical, chemotherapy and radiotherapy alternatives. Is an international collaborative RCT destined for the "too difficult to do" box?
O'Donnell RL, Verleye L, Ratnavelu N, Galaal K, Fisher A, Naik R
Gynecol Oncol 2017 Feb;144(2):438-447. Epub 2016 Dec 27 doi: 10.1016/j.ygyno.2016.12.007. PMID: 28034465

Diagnosis

Comorbidity in patients with Lichen sclerosus: a retrospective cohort study.
Gulin SJ, Lundin F, Seifert O
Eur J Med Res 2023 Sep 11;28(1):338. doi: 10.1186/s40001-023-01335-9. PMID: 37697418Free PMC Article
Sexual and Psychosexual Consequences of Treatment for Gynaecological Cancers.
Rizzuto I, Oehler MK, Lalondrelle S
Clin Oncol (R Coll Radiol) 2021 Sep;33(9):602-607. Epub 2021 Jul 17 doi: 10.1016/j.clon.2021.07.003. PMID: 34281725
Mapping evidence on ovarian, endometrial, vaginal, and vulva cancer research in Africa: a scoping review protocol.
Ninimiya SY, Ansu-Mensah M, Bawontuo V, Kuupiel D
Syst Rev 2021 Apr 14;10(1):108. doi: 10.1186/s13643-021-01654-0. PMID: 33849664Free PMC Article
Cold Atmospheric Pressure Plasma (CAP) as a New Tool for the Management of Vulva Cancer and Vulvar Premalignant Lesions in Gynaecological Oncology.
Zubor P, Wang Y, Liskova A, Samec M, Koklesova L, Dankova Z, Dørum A, Kajo K, Dvorska D, Lucansky V, Malicherova B, Kasubova I, Bujnak J, Mlyncek M, Dussan CA, Kubatka P, Büsselberg D, Golubnitschaja O
Int J Mol Sci 2020 Oct 27;21(21) doi: 10.3390/ijms21217988. PMID: 33121141Free PMC Article
Lymphatic mapping and sentinel node biopsy in gynecological cancers: a critical review of the literature.
Ayhan A, Celik H, Dursun P
World J Surg Oncol 2008 May 20;6:53. doi: 10.1186/1477-7819-6-53. PMID: 18492253Free PMC Article

Therapy

Immunotherapy and radiation therapy sequencing: State of the data on timing, efficacy, and safety.
Williamson CW, Sherer MV, Zamarin D, Sharabi AB, Dyer BA, Mell LK, Mayadev JS
Cancer 2021 May 15;127(10):1553-1567. Epub 2021 Feb 23 doi: 10.1002/cncr.33424. PMID: 33620731Free PMC Article
Cold Atmospheric Pressure Plasma (CAP) as a New Tool for the Management of Vulva Cancer and Vulvar Premalignant Lesions in Gynaecological Oncology.
Zubor P, Wang Y, Liskova A, Samec M, Koklesova L, Dankova Z, Dørum A, Kajo K, Dvorska D, Lucansky V, Malicherova B, Kasubova I, Bujnak J, Mlyncek M, Dussan CA, Kubatka P, Büsselberg D, Golubnitschaja O
Int J Mol Sci 2020 Oct 27;21(21) doi: 10.3390/ijms21217988. PMID: 33121141Free PMC Article
Locally advanced vulva cancer: A single centre review of anovulvectomy and a systematic review of surgical, chemotherapy and radiotherapy alternatives. Is an international collaborative RCT destined for the "too difficult to do" box?
O'Donnell RL, Verleye L, Ratnavelu N, Galaal K, Fisher A, Naik R
Gynecol Oncol 2017 Feb;144(2):438-447. Epub 2016 Dec 27 doi: 10.1016/j.ygyno.2016.12.007. PMID: 28034465
A review of complications associated with the surgical treatment of vulvar cancer.
Wills A, Obermair A
Gynecol Oncol 2013 Nov;131(2):467-79. Epub 2013 Jul 14 doi: 10.1016/j.ygyno.2013.07.082. PMID: 23863358
Chemotherapy and radiation therapy in the treatment of squamous cell carcinoma of the vulva: Are two therapies better than one?
Moore DH
Gynecol Oncol 2009 Jun;113(3):379-83. Epub 2009 Feb 20 doi: 10.1016/j.ygyno.2009.01.004. PMID: 19232700

Prognosis

Temporal Trends and Projection of Cancer Attributable to Human Papillomavirus Infection in China, 2007-2030.
Duan R, Xu K, Huang L, Yuan M, Wang H, Qiao Y, Zhao F
Cancer Epidemiol Biomarkers Prev 2022 May 4;31(5):1130-1136. doi: 10.1158/1055-9965.EPI-21-1124. PMID: 35266990
Sexual and Psychosexual Consequences of Treatment for Gynaecological Cancers.
Rizzuto I, Oehler MK, Lalondrelle S
Clin Oncol (R Coll Radiol) 2021 Sep;33(9):602-607. Epub 2021 Jul 17 doi: 10.1016/j.clon.2021.07.003. PMID: 34281725
Cold Atmospheric Pressure Plasma (CAP) as a New Tool for the Management of Vulva Cancer and Vulvar Premalignant Lesions in Gynaecological Oncology.
Zubor P, Wang Y, Liskova A, Samec M, Koklesova L, Dankova Z, Dørum A, Kajo K, Dvorska D, Lucansky V, Malicherova B, Kasubova I, Bujnak J, Mlyncek M, Dussan CA, Kubatka P, Büsselberg D, Golubnitschaja O
Int J Mol Sci 2020 Oct 27;21(21) doi: 10.3390/ijms21217988. PMID: 33121141Free PMC Article
Sexual, psychological, and relational functioning in women after surgical treatment for vulvar malignancy: a literature review.
Aerts L, Enzlin P, Vergote I, Verhaeghe J, Poppe W, Amant F
J Sex Med 2012 Feb;9(2):361-71. Epub 2011 Nov 14 doi: 10.1111/j.1743-6109.2011.02520.x. PMID: 22082135
Lymphatic mapping and sentinel node biopsy in gynecological cancers: a critical review of the literature.
Ayhan A, Celik H, Dursun P
World J Surg Oncol 2008 May 20;6:53. doi: 10.1186/1477-7819-6-53. PMID: 18492253Free PMC Article

Clinical prediction guides

Burden of HPV-Related Hospitalization in Germany from 2000 to 2021.
Tampakoudis G, Anastasiou OE
Viruses 2023 Aug 31;15(9) doi: 10.3390/v15091857. PMID: 37766265Free PMC Article
Financial toxicity in patients with gynecologic malignancies: a cross sectional study.
Zeybek B, Webster E, Pogosian N, Tymon-Rosario J, Balch A, Altwerger G, Clark M, Menderes G, Huang G, Azodi M, Ratner ES, Schwartz PE, Santin AD, Andikyan V
J Gynecol Oncol 2021 Nov;32(6):e87. Epub 2021 Jul 23 doi: 10.3802/jgo.2021.32.e87. PMID: 34431257Free PMC Article
Cold Atmospheric Pressure Plasma (CAP) as a New Tool for the Management of Vulva Cancer and Vulvar Premalignant Lesions in Gynaecological Oncology.
Zubor P, Wang Y, Liskova A, Samec M, Koklesova L, Dankova Z, Dørum A, Kajo K, Dvorska D, Lucansky V, Malicherova B, Kasubova I, Bujnak J, Mlyncek M, Dussan CA, Kubatka P, Büsselberg D, Golubnitschaja O
Int J Mol Sci 2020 Oct 27;21(21) doi: 10.3390/ijms21217988. PMID: 33121141Free PMC Article
Locally advanced vulva cancer: A single centre review of anovulvectomy and a systematic review of surgical, chemotherapy and radiotherapy alternatives. Is an international collaborative RCT destined for the "too difficult to do" box?
O'Donnell RL, Verleye L, Ratnavelu N, Galaal K, Fisher A, Naik R
Gynecol Oncol 2017 Feb;144(2):438-447. Epub 2016 Dec 27 doi: 10.1016/j.ygyno.2016.12.007. PMID: 28034465
Lymphatic mapping and sentinel node biopsy in gynecological cancers: a critical review of the literature.
Ayhan A, Celik H, Dursun P
World J Surg Oncol 2008 May 20;6:53. doi: 10.1186/1477-7819-6-53. PMID: 18492253Free PMC Article

Recent systematic reviews

Assessing Patient-reported Quality of Life Outcomes in Vulva Cancer Patients: A Systematic Literature Review.
Froeding LP, Greimel E, Lanceley A, Oberguggenberger A, Schmalz C, Radisic VB, Nordin A, Galalaei R, Kuljanic K, Vistad I, Schnack TH, Jensen PT; European Organization of Research Treatment of Cancer Quality of Life Group the Gynecological Cancer group
Int J Gynecol Cancer 2018 May;28(4):808-817. doi: 10.1097/IGC.0000000000001211. PMID: 29420364
Locally advanced vulva cancer: A single centre review of anovulvectomy and a systematic review of surgical, chemotherapy and radiotherapy alternatives. Is an international collaborative RCT destined for the "too difficult to do" box?
O'Donnell RL, Verleye L, Ratnavelu N, Galaal K, Fisher A, Naik R
Gynecol Oncol 2017 Feb;144(2):438-447. Epub 2016 Dec 27 doi: 10.1016/j.ygyno.2016.12.007. PMID: 28034465

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