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Study Description

Recently, tumor sequencing and profiling analyses have improved molecular classification and refined existing breast cancer subtypes. However, epidemiologic data are absent in most somatic profiling studies even in extensively studied Western populations. The expansion of genomic studies to understudied populations with the integration of etiologic factors will allow the capture of a much wider range of genetic structure and mutagenic exposures associated with breast cancer risk. We therefore conducted a detailed molecular characterization of paired breast tumor/normal tissues using fresh frozen tissues collected from breast cancer cases in an ongoing breast cancer case-control study in Hong Kong. These analyses included whole exome sequencing, RNA sequencing, and genome-wide methylation profiling analyses.

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Molecular Data
TypeSourcePlatformNumber of Oligos/SNPsSNP Batch IdComment
RNA Sequencing Illumina HiSeq 4000 N/A N/A
Whole Exome Sequencing Illumina HiSeq 2000 N/A N/A
Whole Exome Sequencing Roche NimbleGen SeqCap EZ Exome v3 N/A N/A
Methylation Array Illumina Illumina-Infinium CytoSNP-850K N/A N/A
Selected Publications
Diseases/Traits Related to Study (MeSH terms)
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Study Attribution
  • Principal Investigator
    • Rose Yang, PhD. National Institutes of Health, Bethesda, MD, USA.
  • Funding Source
    • Intramural research. National Institutes of Health, Bethesda, MD, USA.