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    LOC127268961 OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:44232560-44233095 [ Homo sapiens (human) ]

    Gene ID: 127268961, updated on 10-Oct-2023

    Summary

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    Gene symbol
    LOC127268961
    Gene description
    OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:44232560-44233095
    Gene type
    biological region
    Feature type(s)
    regulatory: enhancer
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This genomic region was validated as an active enhancer by the ChIP-STARR-seq massively parallel reporter assay in primed human embryonic stem cells. This enhancer associates with the OCT4 and NANOG transcription factors and is marked by the H3K27ac histone modification. [provided by RefSeq, Oct 2022]
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    Genomic context

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    See LOC127268961 in Genome Data Viewer
    Location:
    chromosome: 1
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (43766889..43767424)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (43637706..43638241)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene lysine demethylase 4A Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:44172642-44173159 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 790 Neighboring gene KDM4A antisense RNA 1 Neighboring gene ST3GAL3 antisense RNA 1 Neighboring gene uncharacterized LOC124904721 Neighboring gene ST3 beta-galactoside alpha-2,3-sialyltransferase 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 923 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 924 Neighboring gene uncharacterized LOC124904166 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 791 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr1:44287043-44288242 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:44299839-44300606 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:44300607-44301374 Neighboring gene microRNA 6079

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_090822.1 

      Range
      101..636
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      43766889..43767424
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      43637706..43638241
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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