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    gcy-34 Soluble guanylate cyclase gcy-34 [ Caenorhabditis elegans ]

    Gene ID: 191656, updated on 12-Jun-2024

    Summary

    Gene symbol
    gcy-34
    Gene description
    Soluble guanylate cyclase gcy-34
    Locus tag
    CELE_M04G12.3
    See related
    AllianceGenome:WB:WBGene00001554
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable several functions, including GTP binding activity; guanylate cyclase activity; and heme binding activity. Involved in chemosensory behavior and sensory perception of bitter taste. Predicted to be located in cytoplasm. Is expressed in AQR; PQR; URXL; and URXR. Orthologous to human GUCY1B1 (guanylate cyclase 1 soluble subunit beta 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

    See gcy-34 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    9
    Sequence:
    Chromosome: V; NC_003283.11 (13383019..13385898, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Serpentine receptor class gamma-46 Neighboring gene 7TM GPCR serpentine receptor class x (Srx) domain-containing protein Neighboring gene IRF-2BP1_2 domain-containing protein;Interferon regulatory factor 2-binding protein 1 & 2 zinc finger domain-containing protein;RING-type domain-containing protein Neighboring gene cathepsin X Neighboring gene Zinc finger protein somi-1 Neighboring gene ncRNA Neighboring gene ZP domain-containing protein

    General gene information

    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables guanylate cyclase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables guanylate cyclase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in cGMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cGMP-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in chemosensory behavior IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in chemosensory behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cyclic nucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to oxygen levels IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in response to stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in sensory perception of bitter taste IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in sensory perception of bitter taste IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    part_of guanylate cyclase complex, soluble IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    Soluble guanylate cyclase gcy-34
    NP_506319.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      13383019..13385898 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_073918.6NP_506319.1  Soluble guanylate cyclase gcy-34 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_506319.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P92006
      Conserved Domains (3) summary
      smart00044
      Location:421609
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      pfam07700
      Location:3167
      HNOB; Haem-NO-binding
      pfam07701
      Location:224441
      HNOBA; Heme NO binding associated