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    ncam1a neural cell adhesion molecule 1a [ Danio rerio (zebrafish) ]

    Gene ID: 30447, updated on 11-Apr-2024

    Summary

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    Official Symbol
    ncam1aprovided by ZNC
    Official Full Name
    neural cell adhesion molecule 1aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-990415-31
    See related
    Ensembl:ENSDARG00000056181 AllianceGenome:ZFIN:ZDB-GENE-990415-31
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    ncam; ncam1; fj56g09; wu:fj56g09
    Summary
    Acts upstream of or within posterior commissure morphogenesis. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in several structures, including anterior neural keel; myotome; nervous system; optic vesicle; and pectoral fin. Human ortholog(s) of this gene implicated in bipolar disorder; middle cerebral artery infarction; and pancreatic cancer. Orthologous to human NCAM1 (neural cell adhesion molecule 1). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See ncam1a in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (23334125..23746960, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (23297520..23710790, complement)

    Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene 5-hydroxytryptamine (serotonin) receptor 3A Neighboring gene zinc finger and BTB domain containing 16a Neighboring gene uncharacterized LOC108180750 Neighboring gene uncharacterized LOC101885070 Neighboring gene uncharacterized LOC101884169 Neighboring gene uncharacterized LOC798286

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Genesis of rods in the zebrafish retina occurs in a microenvironment provided by polysialic acid-expressing Müller glia. Kustermann S, et al. J Comp Neurol, 2010 Mar 1. PMID 20034055
    2. Antibody to the HNK-1 glycoepitope affects fasciculation and axonal pathfinding in the developing posterior lateral line nerve of embryonic zebrafish. Becker T, et al. Mech Dev, 2001 Nov. PMID 11677051
    3. Polysialyltransferase expression is linked to neuronal migration in the developing and adult zebrafish. Rieger S, et al. Dev Dyn, 2008 Jan. PMID 18095350
    4. Transcriptomic analysis of zebrafish prion protein mutants supports conserved cross-species function of the cellular prion protein. Pollock NM, et al. Prion, 2021 Dec. PMID 34139950, Free PMC Article
    5. Involvement of L1.1 in memory consolidation after active avoidance conditioning in zebrafish. Pradel G, et al. J Neurobiol, 2000 Jun 15. PMID 10861564

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ncam1a and Ncam1b: two carriers of polysialic acid with different functions in the developing zebrafish nervous system.
      Title: Ncam1a and Ncam1b: two carriers of polysialic acid with different functions in the developing zebrafish nervous system.
    2. Thus, polySia-negative rod precursors of the mature zebrafish retina face a polySia-NCAM-positive microenvironment presented by radial Muller glia.
      Title: Genesis of rods in the zebrafish retina occurs in a microenvironment provided by polysialic acid-expressing Müller glia.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within posterior commissure morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    neural cell adhesion molecule 1; neural cell adhesion molecule 1a

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131202.2 → NP_571277.2  neural cell adhesion molecule 1a precursor

      See identical proteins and their annotated locations for NP_571277.2

      Status: VALIDATED

      Source sequence(s)
      BC162675, BX005227, CR388411
      UniProtKB/TrEMBL
      B3DH85, E7CR05, F6P9B5
      Related
      ENSDARP00000017613.7, ENSDART00000017229.9
      Conserved Domains (8) summary
      cd05869
      Location:300 → 396
      Ig5_NCAM-1; Fifth immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-1 (NCAM)
      smart00408
      Location:128 → 189
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:219 → 298
      IG_like; Immunoglobulin like
      cd00063
      Location:592 → 683
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:21 → 111
      I-set; Immunoglobulin I-set domain
      pfam00041
      Location:495 → 579
      fn3; Fibronectin type III domain
      pfam00047
      Location:403 → 488
      ig; Immunoglobulin domain
      cl11960
      Location:20 → 112
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007132.7 Reference GRCz11 Primary Assembly

      Range
      23334125..23746960 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009295280.3 → XP_009293555.1  neural cell adhesion molecule 1 isoform X1

      UniProtKB/TrEMBL
      A0A8M3ATS9
      Conserved Domains (7) summary
      smart00408
      Location:128 → 189
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:219 → 298
      IG_like; Immunoglobulin like
      cd00063
      Location:624 → 715
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:21 → 111
      I-set; Immunoglobulin I-set domain
      pfam00041
      Location:505 → 589
      fn3; Fibronectin type III domain
      pfam00047
      Location:413 → 498
      ig; Immunoglobulin domain
      cl11960
      Location:300 → 406
      Ig; Immunoglobulin domain

    2. XM_017352744.2 → XP_017208233.1  neural cell adhesion molecule 1 isoform X4

      UniProtKB/TrEMBL
      A0A8M6Z3L2

    3. XM_009295281.3 → XP_009293556.1  neural cell adhesion molecule 1 isoform X3

      UniProtKB/TrEMBL
      A0A8M3ALE2
      Conserved Domains (8) summary
      cd05869
      Location:300 → 396
      Ig5_NCAM-1; Fifth immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-1 (NCAM)
      smart00408
      Location:128 → 189
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:219 → 298
      IG_like; Immunoglobulin like
      cd00063
      Location:614 → 705
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:21 → 111
      I-set; Immunoglobulin I-set domain
      pfam00041
      Location:495 → 579
      fn3; Fibronectin type III domain
      pfam00047
      Location:403 → 488
      ig; Immunoglobulin domain
      cl11960
      Location:20 → 112
      Ig; Immunoglobulin domain

    4. XM_005161138.4 → XP_005161195.1  neural cell adhesion molecule 1 isoform X7

      UniProtKB/TrEMBL
      A0A8M2B8D1
      Related
      ENSDARP00000130606.2, ENSDART00000157454.2
      Conserved Domains (7) summary
      smart00408
      Location:128 → 189
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:219 → 298
      IG_like; Immunoglobulin like
      cd00063
      Location:602 → 693
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:21 → 111
      I-set; Immunoglobulin I-set domain
      pfam00041
      Location:505 → 589
      fn3; Fibronectin type III domain
      pfam00047
      Location:413 → 498
      ig; Immunoglobulin domain
      cl11960
      Location:300 → 406
      Ig; Immunoglobulin domain

    5. XM_005161137.4 → XP_005161194.1  neural cell adhesion molecule 1 isoform X6

      UniProtKB/TrEMBL
      A0A8M2B821
      Conserved Domains (7) summary
      smart00408
      Location:128 → 189
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:219 → 298
      IG_like; Immunoglobulin like
      cd00063
      Location:603 → 694
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:21 → 111
      I-set; Immunoglobulin I-set domain
      pfam00041
      Location:505 → 589
      fn3; Fibronectin type III domain
      pfam00047
      Location:413 → 498
      ig; Immunoglobulin domain
      cl11960
      Location:300 → 406
      Ig; Immunoglobulin domain

    6. XM_005161135.4 → XP_005161192.1  neural cell adhesion molecule 1 isoform X2

      UniProtKB/TrEMBL
      A0A8M2B837
      Conserved Domains (7) summary
      smart00408
      Location:128 → 189
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:219 → 298
      IG_like; Immunoglobulin like
      cd00063
      Location:619 → 710
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:21 → 111
      I-set; Immunoglobulin I-set domain
      pfam00041
      Location:505 → 589
      fn3; Fibronectin type III domain
      pfam00047
      Location:413 → 498
      ig; Immunoglobulin domain
      cl11960
      Location:300 → 406
      Ig; Immunoglobulin domain

    7. XM_009295282.3 → XP_009293557.1  neural cell adhesion molecule 1 isoform X5

      UniProtKB/TrEMBL
      A0A8M3B4M6
      Conserved Domains (7) summary
      smart00408
      Location:128 → 189
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:219 → 298
      IG_like; Immunoglobulin like
      cd00063
      Location:608 → 699
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:21 → 111
      I-set; Immunoglobulin I-set domain
      pfam00041
      Location:505 → 589
      fn3; Fibronectin type III domain
      pfam00047
      Location:413 → 498
      ig; Immunoglobulin domain
      cl11960
      Location:300 → 406
      Ig; Immunoglobulin domain

    8. XM_009295286.3 → XP_009293561.1  neural cell adhesion molecule 1 isoform X9

      UniProtKB/TrEMBL
      A0A8M3AM36
      Conserved Domains (7) summary
      smart00408
      Location:128 → 189
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:219 → 298
      IG_like; Immunoglobulin like
      cd00063
      Location:624 → 715
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:21 → 111
      I-set; Immunoglobulin I-set domain
      pfam00041
      Location:505 → 589
      fn3; Fibronectin type III domain
      pfam00047
      Location:413 → 498
      ig; Immunoglobulin domain
      cl11960
      Location:300 → 406
      Ig; Immunoglobulin domain

    9. XM_005161139.4 → XP_005161196.1  neural cell adhesion molecule 1 isoform X8

      UniProtKB/TrEMBL
      A0A8M2B824
      Related
      ENSDARP00000128320.3, ENSDART00000156658.3
      Conserved Domains (8) summary
      cd05869
      Location:300 → 396
      Ig5_NCAM-1; Fifth immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-1 (NCAM)
      smart00408
      Location:128 → 189
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:219 → 298
      IG_like; Immunoglobulin like
      cd00063
      Location:592 → 683
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:21 → 111
      I-set; Immunoglobulin I-set domain
      pfam00041
      Location:495 → 579
      fn3; Fibronectin type III domain
      pfam00047
      Location:403 → 488
      ig; Immunoglobulin domain
      cl11960
      Location:20 → 112
      Ig; Immunoglobulin domain

    10. XM_017352746.2 → XP_017208235.1  neural cell adhesion molecule 1 isoform X14

      UniProtKB/TrEMBL
      A0A8M6Z2Y4

    11. XM_017352745.2 → XP_017208234.1  neural cell adhesion molecule 1 isoform X11

      UniProtKB/TrEMBL
      A0A8M6YUF3

    12. XM_005161141.4 → XP_005161198.2  neural cell adhesion molecule 1 isoform X10

      UniProtKB/TrEMBL
      A0A8M2B827
      Conserved Domains (7) summary
      smart00408
      Location:128 → 189
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:219 → 298
      IG_like; Immunoglobulin like
      cd00063
      Location:624 → 715
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:21 → 111
      I-set; Immunoglobulin I-set domain
      pfam00041
      Location:505 → 589
      fn3; Fibronectin type III domain
      pfam00047
      Location:413 → 498
      ig; Immunoglobulin domain
      cl11960
      Location:300 → 406
      Ig; Immunoglobulin domain

    13. XM_005161142.4 → XP_005161199.1  neural cell adhesion molecule 1 isoform X12

      UniProtKB/TrEMBL
      A0A8M2B851
      Conserved Domains (8) summary
      cd05869
      Location:300 → 396
      Ig5_NCAM-1; Fifth immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-1 (NCAM)
      smart00408
      Location:128 → 189
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:219 → 298
      IG_like; Immunoglobulin like
      cd00063
      Location:592 → 683
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:21 → 111
      I-set; Immunoglobulin I-set domain
      pfam00041
      Location:495 → 579
      fn3; Fibronectin type III domain
      pfam00047
      Location:403 → 488
      ig; Immunoglobulin domain
      cl11960
      Location:20 → 112
      Ig; Immunoglobulin domain

    14. XM_009295288.3 → XP_009293563.1  neural cell adhesion molecule 1 isoform X13

      UniProtKB/TrEMBL
      A0A8M3AWT0
      Conserved Domains (6) summary
      smart00408
      Location:128 → 189
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:219 → 298
      IG_like; Immunoglobulin like
      pfam07679
      Location:21 → 111
      I-set; Immunoglobulin I-set domain
      pfam00041
      Location:505 → 589
      fn3; Fibronectin type III domain
      pfam00047
      Location:413 → 498
      ig; Immunoglobulin domain
      cl11960
      Location:300 → 406
      Ig; Immunoglobulin domain
    Nucleotide Protein Strain
    Heading Accession and Version

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