Gipr gastric inhibitory polypeptide receptor [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Giprprovided by MGI
Official Full Name: gastric inhibitory polypeptide receptorprovided by MGI
Primary source: MGI:MGI:1352753
See related: Ensembl:ENSMUSG00000030406 AllianceGenome:MGI:1352753
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: GIP-R; Gm160; Gm1081
Summary: Predicted to enable G protein-coupled peptide receptor activity; gastric inhibitory peptide receptor activity; and glucagon family peptide binding activity. Acts upstream of or within endocrine pancreas development. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Is expressed in foregut-midgut junction; pancreas; and pancreas primordium. Human ortholog(s) of this gene implicated in cardiovascular system disease; diabetes mellitus; obesity; and type 2 diabetes mellitus. Orthologous to human GIPR (gastric inhibitory polypeptide receptor). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in CNS E18 (RPKM 9.0), testis adult (RPKM 4.8) and 10 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 A3; 7 9.46 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (18889988..18904173, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (19156063..19170248, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Loss of GIPR in LEPR cells impairs glucose control by GIP and GIP:GLP-1 co-agonism without affecting body weight and food intake in mice.
Title: Loss of GIPR in LEPR cells impairs glucose control by GIP and GIP:GLP-1 co-agonism without affecting body weight and food intake in mice.
Gastric inhibitory polypeptide receptor antagonism suppresses intramuscular adipose tissue accumulation and ameliorates sarcopenia.
Title: Gastric inhibitory polypeptide receptor antagonism suppresses intramuscular adipose tissue accumulation and ameliorates sarcopenia.
Genetic disruption of the Gipr in Apoe(-/-) mice promotes atherosclerosis.
Title: Genetic disruption of the Gipr in Apoe(-/-) mice promotes atherosclerosis.
Activation of GIPR Exerts Analgesic and Anxiolytic-Like Effects in the Anterior Cingulate Cortex of Mice.
Title: Activation of GIPR Exerts Analgesic and Anxiolytic-Like Effects in the Anterior Cingulate Cortex of Mice.
GIPR gene expression in testis is mouse specific and can impact male mouse fertility.
Title: GIPR gene expression in testis is mouse specific and can impact male mouse fertility.
GIPR Is Predominantly Localized to Nonadipocyte Cell Types Within White Adipose Tissue.
Title: GIPR Is Predominantly Localized to Nonadipocyte Cell Types Within White Adipose Tissue.
Targeting the GIPR for obesity: To agonize or antagonize? Potential mechanisms.
Title: Targeting the GIPR for obesity: To agonize or antagonize? Potential mechanisms.
GIPR Signaling in Immune Cells Maintains Metabolically Beneficial Type 2 Immune Responses in the White Fat From Obese Mice.
Title: GIPR Signaling in Immune Cells Maintains Metabolically Beneficial Type 2 Immune Responses in the White Fat From Obese Mice.
The gut hormone receptor GIPR links energy availability to the control of hematopoiesis.
Title: The gut hormone receptor GIPR links energy availability to the control of hematopoiesis.
GIP receptor deletion in mice confers resistance to high-fat diet-induced obesity via alterations in energy expenditure and adipose tissue lipid metabolism.
Title: GIP receptor deletion in mice confers resistance to high-fat diet-induced obesity via alterations in energy expenditure and adipose tissue lipid metabolism.

Submit: New GeneRIF Correction See all GeneRIFs (50)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (6) 1 citation
Targeted (8) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:492156

Gipr (e-PCR), detects polymorphism
- UniSTS:548042

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled peptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables gastric inhibitory peptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables gastric inhibitory peptide receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables gastric inhibitory peptide receptor activity	ISO Inferred from Sequence Orthology more info	PubMed
enables glucagon family peptide binding	ISO Inferred from Sequence Orthology more info
enables peptide hormone binding	IBA Inferred from Biological aspect of Ancestor more info
enables peptide hormone binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor activity	TAS Traceable Author Statement more info	PubMed
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info	PubMed
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in desensitization of G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within endocrine pancreas development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gastric inhibitory peptide signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuropeptide signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of cAMP-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of insulin secretion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of insulin secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of insulin secretion	ISO Inferred from Sequence Orthology more info	PubMed
involved_in response to calcium ion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: gastric inhibitory polypeptide receptor

Names: glucose-dependent insulinotropic polypeptide receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001080815.1 → NP_001074284.1 gastric inhibitory polypeptide receptor precursor

See identical proteins and their annotated locations for NP_001074284.1

Status: PROVISIONAL

Source sequence(s)

AC145199

Consensus CDS

CCDS39795.1

UniProtKB/Swiss-Prot

Q0P543, Q80UB4

Related

ENSMUSP00000092384.4, ENSMUST00000094790.5

Conserved Domains (2) summary

pfam00002
Location:130 → 384

7tm_2; 7 transmembrane receptor (Secretin family)

pfam02793
Location:54 → 117

HRM; Hormone receptor domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

18889988..18904173 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006540142.2 → XP_006540205.1 gastric inhibitory polypeptide receptor isoform X1

See identical proteins and their annotated locations for XP_006540205.1

Conserved Domains (2) summary

cd15929
Location:130 → 447

7tmB1_GlucagonR-like; glucagon receptor-like subfamily, member of the class B family of seven-transmembrane G protein-coupled receptors

pfam02793
Location:54 → 117

HRM; Hormone receptor domain
XM_006540143.2 → XP_006540206.1 gastric inhibitory polypeptide receptor isoform X1

See identical proteins and their annotated locations for XP_006540206.1

Conserved Domains (2) summary

cd15929
Location:130 → 447

7tmB1_GlucagonR-like; glucagon receptor-like subfamily, member of the class B family of seven-transmembrane G protein-coupled receptors

pfam02793
Location:54 → 117

HRM; Hormone receptor domain
XM_006540144.2 → XP_006540207.1 gastric inhibitory polypeptide receptor isoform X2

See identical proteins and their annotated locations for XP_006540207.1

Related

ENSMUST00000206857.2

Conserved Domains (2) summary

cd15929
Location:86 → 403

7tmB1_GlucagonR-like; glucagon receptor-like subfamily, member of the class B family of seven-transmembrane G protein-coupled receptors

pfam02793
Location:10 → 73

HRM; Hormone receptor domain
XM_006540145.2 → XP_006540208.1 gastric inhibitory polypeptide receptor isoform X2

See identical proteins and their annotated locations for XP_006540208.1

Conserved Domains (2) summary

cd15929
Location:86 → 403

7tmB1_GlucagonR-like; glucagon receptor-like subfamily, member of the class B family of seven-transmembrane G protein-coupled receptors

pfam02793
Location:10 → 73

HRM; Hormone receptor domain