TRIM72 tripartite motif containing 72 [Homo sapiens (human)] - Gene

Summary

Official Symbol: TRIM72provided by HGNC
Official Full Name: tripartite motif containing 72provided by HGNC
Primary source: HGNC:HGNC:32671
See related: Ensembl:ENSG00000177238 MIM:613288; AllianceGenome:HGNC:32671
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MG53
Summary: Enables identical protein binding activity. Predicted to be involved in several processes, including cellular protein metabolic process; plasma membrane repair; and protein homooligomerization. Predicted to act upstream of or within negative regulation of insulin receptor signaling pathway; negative regulation of insulin-like growth factor receptor signaling pathway; and negative regulation of myotube differentiation. Predicted to be located in cytoplasmic vesicle membrane. Predicted to be active in cytoplasm and sarcolemma. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in prostate (RPKM 2.0), esophagus (RPKM 0.3) and 1 other tissue See more
Orthologs: mouse all
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Genomic context

Location:: 16p11.2

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	16	NC_000016.10 (31214119..31231537)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	16	NC_060940.1 (31601549..31618973)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	16	NC_000016.9 (31225440..31242858)

Chromosome 16 - NC_000016.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Targeting TRIM Proteins: A Quest towards Drugging an Emerging Protein Class.
Title: Targeting TRIM Proteins: A Quest towards Drugging an Emerging Protein Class.
TRIM proteins trim the balance of homoeostasis by modulating various biological pathways through protein-protein interactions.
Title: TRIM proteins as trim tabs for the homoeostasis.
MG53 ameliorates nerve injury induced neuropathic pain through the regulation of Nrf2/HO-1 signaling in rats.
Title: MG53 ameliorates nerve injury induced neuropathic pain through the regulation of Nrf2/HO-1 signaling in rats.
Tripartite motif 72 inhibits apoptosis and mitochondrial dysfunction in neural stem cells induced by anesthetic sevoflurane by activating PI3K/AKT pathway.
Title: Tripartite motif 72 inhibits apoptosis and mitochondrial dysfunction in neural stem cells induced by anesthetic sevoflurane by activating PI3K/AKT pathway.
Cryo-EM structure of human MG53 homodimer.
Title: Cryo-EM structure of human MG53 homodimer.
MG53 represses high glucose-induced inflammation and angiogenesis in human retinal endothelial cells by repressing the EGR1/STAT3 axis.
Title: MG53 represses high glucose-induced inflammation and angiogenesis in human retinal endothelial cells by repressing the EGR1/STAT3 axis.
Ubiquitination and degradation of MGMT by TRIM72 increases the sensitivity of uveal melanoma cells to Dacarbazine treatment.
Title: Ubiquitination and degradation of MGMT by TRIM72 increases the sensitivity of uveal melanoma cells to Dacarbazine treatment.
TRIM72 exerts antitumor effects in breast cancer and modulates lactate production and MCT4 promoter activity by interacting with PPP3CA.
Title: TRIM72 exerts antitumor effects in breast cancer and modulates lactate production and MCT4 promoter activity by interacting with PPP3CA.
MG53 suppresses tumor progression and stress granule formation by modulating G3BP2 activity in non-small cell lung cancer.
Title: MG53 suppresses tumor progression and stress granule formation by modulating G3BP2 activity in non-small cell lung cancer.
MG53/CAV1 regulates transforming growth factor-beta1 signaling-induced atrial fibrosis in atrial fibrillation.
Title: MG53/CAV1 regulates transforming growth factor-β1 signaling-induced atrial fibrosis in atrial fibrillation.

Submit: New GeneRIF Correction See all GeneRIFs (28)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH103987 (e-PCR)
- UniSTS:98312

G35510 (e-PCR)
- UniSTS:44150

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables mitogen-activated protein kinase kinase kinase binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylserine binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin conjugating enzyme binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in exocytosis	IEA Inferred from Electronic Annotation more info
involved_in muscle organ development	ISS Inferred from Sequence or Structural Similarity more info
involved_in muscle system process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of insulin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of insulin-like growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of myotube differentiation	IEA Inferred from Electronic Annotation more info
involved_in plasma membrane repair	ISS Inferred from Sequence or Structural Similarity more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein homooligomerization	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic vesicle membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasmic vesicle membrane	TAS Traceable Author Statement more info
is_active_in sarcolemma	IBA Inferred from Biological aspect of Ancestor more info
located_in sarcolemma	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: tripartite motif-containing protein 72

Names: mitsugumin-53; tripartite motif containing 72, E3 ubiquitin protein ligase

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001008274.4 → NP_001008275.2 tripartite motif-containing protein 72

See identical proteins and their annotated locations for NP_001008275.2

Status: VALIDATED

Source sequence(s)

AC009088, AK131485, DA058421

Consensus CDS

CCDS32437.1

UniProtKB/Swiss-Prot

Q6ZMU5, Q8N4X6, Q8NBD9

Related

ENSP00000312675.3, ENST00000322122.8

Conserved Domains (3) summary

cd13742
Location:278 → 470

SPRY_PRY_TRIM72; PRY/SPRY domain in tripartite motif-binding protein 72 (TRIM72)

cd16612
Location:11 → 57

RING-HC_TRIM72_C-IV; RING finger, HC subclass, found in tripartite motif-containing protein 72 (TRIM72) and similar proteins

cl00034
Location:84 → 125

Bbox_SF; B-box-type zinc finger superfamily