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    OTUD7B OTU deubiquitinase 7B [ Homo sapiens (human) ]

    Gene ID: 56957, updated on 17-Mar-2024

    Summary

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    Official Symbol
    OTUD7Bprovided by HGNC
    Official Full Name
    OTU deubiquitinase 7Bprovided by HGNC
    Primary source
    HGNC:HGNC:16683
    See related
    Ensembl:ENSG00000264522 MIM:611748; AllianceGenome:HGNC:16683
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZA20D1; CEZANNE
    Summary
    Enables Lys48-specific deubiquitinase activity and thiol-dependent deubiquitinase. Involved in several processes, including negative regulation of I-kappaB kinase/NF-kappaB signaling; negative regulation of macromolecule metabolic process; and protein deubiquitination. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in fat (RPKM 4.7), testis (RPKM 4.3) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See OTUD7B in Genome Data Viewer
    Location:
    1q21.2
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (149937812..150067653, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (149062296..149192273, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (149909705..149982675, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1665 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1666 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:149908038-149908562 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1667 Neighboring gene splicing factor 3b subunit 4 Neighboring gene myotubularin related protein 11 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:149981420-149982302 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1292 Neighboring gene uncharacterized LOC124904413 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:149989091-149989750 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:149989751-149990408 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1293 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1669 Neighboring gene ribosomal protein L6 pseudogene 31 Neighboring gene vacuolar protein sorting 45 homolog Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:150122046-150122546 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:150131051-150131552 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1296 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1670 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1297 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1298 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1671 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1672 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1673 Neighboring gene pleckstrin homology domain containing O1 Neighboring gene long intergenic non-protein coding RNA 2988 Neighboring gene Sharpr-MPRA regulatory region 9169

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Decreased Cezanne expression is associated with the progression and poor prognosis in hepatocellular carcinoma. Wang JH, et al. J Transl Med, 2015 Feb 1. PMID 25638165, Free PMC Article
    2. [Expression of zinc finger protein A20 in pediatric inflammatory bowel disease]. Zheng CF, et al. Zhonghua Er Ke Za Zhi, 2011 Apr. PMID 21624200
    3. OTUD7B stabilizes estrogen receptor α and promotes breast cancer cell proliferation. Tang J, et al. Cell Death Dis, 2021 May 25. PMID 34035221, Free PMC Article
    4. Cezanne is a critical regulator of pathological arterial remodelling by targeting β-catenin signalling. An W, et al. Cardiovasc Res, 2022 Jan 29. PMID 33599243, Free PMC Article
    5. Cezanne contributes to cancer progression by playing a key role in the deubiquitination of IGF-1R. Chen X, et al. Am J Cancer Res, 2020. PMID 33415003, Free PMC Article

    See all (84) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. OTU deubiquitinase 7B facilitates the hyperthermia-induced inhibition of lung cancer progression through enhancing Smac-mediated mitochondrial dysfunction.
      Title: OTU deubiquitinase 7B facilitates the hyperthermia-induced inhibition of lung cancer progression through enhancing Smac-mediated mitochondrial dysfunction.
    2. OTUD7B deubiquitinates and stabilizes YAP1 to upregulate NUAK2 expression, thus accelerating gastric cancer procession.
      Title: OTUD7B deubiquitinates and stabilizes YAP1 to upregulate NUAK2 expression, thus accelerating gastric cancer procession.
    3. The deubiquitinating enzyme OTUD7b protects dendritic cells from TNF-induced apoptosis by stabilizing the E3 ligase TRAF2.
      Title: The deubiquitinating enzyme OTUD7b protects dendritic cells from TNF-induced apoptosis by stabilizing the E3 ligase TRAF2.
    4. Cezanne is a critical regulator of pathological arterial remodelling by targeting beta-catenin signalling.
      Title: Cezanne is a critical regulator of pathological arterial remodelling by targeting β-catenin signalling.
    5. OTUD7B stabilizes estrogen receptor alpha and promotes breast cancer cell proliferation.
      Title: OTUD7B stabilizes estrogen receptor α and promotes breast cancer cell proliferation.
    6. Oxygen-dependent asparagine hydroxylation of the ubiquitin-associated (UBA) domain in Cezanne regulates ubiquitin binding.
      Title: Oxygen-dependent asparagine hydroxylation of the ubiquitin-associated (UBA) domain in Cezanne regulates ubiquitin binding.
    7. The present study demonstrates that linc00976 enhances the proliferation and invasion ability of PC cells by upregulating OTUD7B expression, which was a target of miR-137. Ultimately, OTUD7B mediates EGFR and MAPK signaling pathway.
      Title: Long noncoding RNA 00976 promotes pancreatic cancer progression through OTUD7B by sponging miR-137 involving EGFR/MAPK pathway.
    8. Cezanne serves as a "reader" of the Lys63-linkage polyubiquitin at DNA damage sites and an "eraser" of the Lys11-linkage ubiquitination, indicating a crosstalk between linkage-specific ubiquitination at DNA damage sites
      Title: Crosstalk between Lys63- and Lys11-polyubiquitin signaling at DNA damage sites is driven by Cezanne.
    9. Cezanne binds established APC/C substrates and reverses their APC/C-mediated ubiquitination. Cezanne depletion accelerates APC/C substrate degradation and causes errors in mitotic progression and formation of micronuclei.
      Title: Cezanne/OTUD7B is a cell cycle-regulated deubiquitinase that antagonizes the degradation of APC/C substrates.
    10. Study demonstrated that the N-terminal UBA domain is crucial for the function of Cezanne during NF-kappaB activation. Cezanne is recognized and recruited into activated TNFR complex by specifically binding to polyubiquitinated signaling proteins after TNF stimulation through its N-terminal polyubiquitin binding site.
      Title: The N-terminal ubiquitin-associated domain of Cezanne is crucial for its function to suppress NF-κB pathway.
    Submit: New GeneRIF Correction See all GeneRIFs (28)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Biological insights from 108 schizophrenia-associated genetic loci.
    EBI GWAS Catalog
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables K48-linked deubiquitinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables K48-linked deubiquitinase activity TAS
    Traceable Author Statement
    more info
    		  
    enables K63-linked polyubiquitin modification-dependent protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type deubiquitinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cysteine-type deubiquitinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables cysteine-type peptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in in utero embryonic development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mucosal immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of canonical NF-kappaB signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of interleukin-8 production IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of protein localization to nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein K11-linked deubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein K11-linked deubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein K48-linked deubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein K48-linked deubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein K48-linked deubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein K63-linked deubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein K63-linked deubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein deubiquitination involved in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    OTU domain-containing protein 7B
    Names
    OTU domain containing 7B
    cellular zinc finger anti-NF-kappa-B protein
    cellular zinc finger anti-NF-kappaB Cezanne
    zinc finger A20 domain-containing protein 1
    zinc finger protein Cezanne
    zinc finger, A20 domain containing 1
    NP_064590.2
    XP_011508084.1
    XP_011508086.1
    XP_011508087.1
    XP_011508090.1
    XP_016857339.1
    XP_047281668.1
    XP_047281671.1
    XP_047281672.1
    XP_047281673.1
    XP_047281676.1
    XP_047281677.1
    XP_054193734.1
    XP_054193735.1
    XP_054193736.1
    XP_054193737.1
    XP_054193738.1
    XP_054193739.1
    XP_054193740.1
    XP_054193741.1
    XP_054193742.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020205.4 → NP_064590.2  OTU domain-containing protein 7B

      See identical proteins and their annotated locations for NP_064590.2

      Status: VALIDATED

      Source sequence(s)
      AC244033, BC015719, BC072681, BP321045, T51077
      Consensus CDS
      CCDS72903.1
      UniProtKB/Swiss-Prot
      B7Z643, D3DUZ8, Q5SZ60, Q6GQQ9, Q8WWA7, Q9NQ53, Q9UFF4
      Related
      ENSP00000462729.1, ENST00000581312.6
      Conserved Domains (4) summary
      cd14347
      Location:4 → 46
      UBA_Cezanne_like; UBA-like domain found in OTU domain-containing proteins OTU7A, OTU7B and similar proteins
      pfam07271
      Location:667 → 797
      Cytadhesin_P30; Cytadhesin P30/P32
      pfam01754
      Location:801 → 823
      zf-A20; A20-like zinc finger
      cl19932
      Location:189 → 359
      OTU; OTU-like cysteine protease

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      149937812..150067653 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047425721.1 → XP_047281677.1  OTU domain-containing protein 7B isoform X2

      UniProtKB/Swiss-Prot
      B7Z643, D3DUZ8, Q5SZ60, Q6GQQ9, Q8WWA7, Q9NQ53, Q9UFF4

    2. XM_047425716.1 → XP_047281672.1  OTU domain-containing protein 7B isoform X1

    3. XM_047425712.1 → XP_047281668.1  OTU domain-containing protein 7B isoform X1

    4. XM_047425720.1 → XP_047281676.1  OTU domain-containing protein 7B isoform X2

      UniProtKB/Swiss-Prot
      B7Z643, D3DUZ8, Q5SZ60, Q6GQQ9, Q8WWA7, Q9NQ53, Q9UFF4

    5. XM_011509784.4 → XP_011508086.1  OTU domain-containing protein 7B isoform X1

      See identical proteins and their annotated locations for XP_011508086.1

      Conserved Domains (3) summary
      cd14347
      Location:4 → 46
      UBA_Cezanne_like; UBA-like domain found in OTU domain-containing proteins OTU7A, OTU7B and similar proteins
      pfam01754
      Location:810 → 832
      zf-A20; A20-like zinc finger
      cl19932
      Location:189 → 359
      OTU; OTU-like cysteine protease

    6. XM_011509782.2 → XP_011508084.1  OTU domain-containing protein 7B isoform X1

      See identical proteins and their annotated locations for XP_011508084.1

      Conserved Domains (3) summary
      cd14347
      Location:4 → 46
      UBA_Cezanne_like; UBA-like domain found in OTU domain-containing proteins OTU7A, OTU7B and similar proteins
      pfam01754
      Location:810 → 832
      zf-A20; A20-like zinc finger
      cl19932
      Location:189 → 359
      OTU; OTU-like cysteine protease

    7. XM_047425715.1 → XP_047281671.1  OTU domain-containing protein 7B isoform X1

    8. XM_047425717.1 → XP_047281673.1  OTU domain-containing protein 7B isoform X2

      UniProtKB/Swiss-Prot
      B7Z643, D3DUZ8, Q5SZ60, Q6GQQ9, Q8WWA7, Q9NQ53, Q9UFF4

    9. XM_011509785.3 → XP_011508087.1  OTU domain-containing protein 7B isoform X1

      See identical proteins and their annotated locations for XP_011508087.1

      Conserved Domains (3) summary
      cd14347
      Location:4 → 46
      UBA_Cezanne_like; UBA-like domain found in OTU domain-containing proteins OTU7A, OTU7B and similar proteins
      pfam01754
      Location:810 → 832
      zf-A20; A20-like zinc finger
      cl19932
      Location:189 → 359
      OTU; OTU-like cysteine protease

    10. XM_017001850.2 → XP_016857339.1  OTU domain-containing protein 7B isoform X4

    11. XM_011509788.3 → XP_011508090.1  OTU domain-containing protein 7B isoform X3

      See identical proteins and their annotated locations for XP_011508090.1

      Conserved Domains (2) summary
      pfam01754
      Location:731 → 753
      zf-A20; A20-like zinc finger
      cl19932
      Location:110 → 280
      OTU; OTU-like cysteine protease

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      149062296..149192273 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054337764.1 → XP_054193739.1  OTU domain-containing protein 7B isoform X2

      UniProtKB/Swiss-Prot
      B7Z643, D3DUZ8, Q5SZ60, Q6GQQ9, Q8WWA7, Q9NQ53, Q9UFF4

    2. XM_054337760.1 → XP_054193735.1  OTU domain-containing protein 7B isoform X1

    3. XM_054337761.1 → XP_054193736.1  OTU domain-containing protein 7B isoform X1

    4. XM_054337763.1 → XP_054193738.1  OTU domain-containing protein 7B isoform X2

      UniProtKB/Swiss-Prot
      B7Z643, D3DUZ8, Q5SZ60, Q6GQQ9, Q8WWA7, Q9NQ53, Q9UFF4

    5. XM_054337759.1 → XP_054193734.1  OTU domain-containing protein 7B isoform X1

    6. XM_054337762.1 → XP_054193737.1  OTU domain-containing protein 7B isoform X1

    7. XM_054337765.1 → XP_054193740.1  OTU domain-containing protein 7B isoform X2

      UniProtKB/Swiss-Prot
      B7Z643, D3DUZ8, Q5SZ60, Q6GQQ9, Q8WWA7, Q9NQ53, Q9UFF4

    8. XM_054337767.1 → XP_054193742.1  OTU domain-containing protein 7B isoform X4

    9. XM_054337766.1 → XP_054193741.1  OTU domain-containing protein 7B isoform X3

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6GQQ9.1 GenPept UniProtKB/Swiss-Prot:Q6GQQ9

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