TRIM36 tripartite motif containing 36 [Homo sapiens (human)] - Gene

Summary

Official Symbol: TRIM36provided by HGNC
Official Full Name: tripartite motif containing 36provided by HGNC
Primary source: HGNC:HGNC:16280
See related: Ensembl:ENSG00000152503 MIM:609317; AllianceGenome:HGNC:16280
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ANPH; ANPH1; RNF98; HAPRIN; RBCC728
Summary: The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Expression: Biased expression in testis (RPKM 36.6), brain (RPKM 4.1) and 4 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 5q22.3

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	5	NC_000005.10 (115124772..115180294, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	5	NC_060929.1 (115637975..115693508, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	5	NC_000005.9 (114460469..114515991, complement)

Chromosome 5 - NC_000005.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FOXA2 Suppression by TRIM36 Exerts Anti-Tumor Role in Colorectal Cancer Via Inducing NRF2/GPX4-Regulated Ferroptosis.
Title: FOXA2 Suppression by TRIM36 Exerts Anti-Tumor Role in Colorectal Cancer Via Inducing NRF2/GPX4-Regulated Ferroptosis.
Genome-wide association study reveals HSF2, GJA1 and TRIM36 as susceptibility genes for preeclampsia: a community-based population study in Tianjin, China.
Title: Genome-wide association study reveals HSF2, GJA1 and TRIM36 as susceptibility genes for preeclampsia: a community-based population study in Tianjin, China.
Trigred motif 36 regulates neuroendocrine differentiation of prostate cancer via HK2 ubiquitination and GPx4 deficiency.
Title: Trigred motif 36 regulates neuroendocrine differentiation of prostate cancer via HK2 ubiquitination and GPx4 deficiency.
TRIM36 enhances lung adenocarcinoma radiosensitivity and inhibits tumorigenesis through promoting RAD51 ubiquitination and antagonizing hsa-miR-376a-5p.
Title: TRIM36 enhances lung adenocarcinoma radiosensitivity and inhibits tumorigenesis through promoting RAD51 ubiquitination and antagonizing hsa-miR-376a-5p.
TRIM36 suppresses cell growth and promotes apoptosis in human esophageal squamous cell carcinoma cells by inhibiting Wnt/beta-catenin signaling pathway.
Title: TRIM36 suppresses cell growth and promotes apoptosis in human esophageal squamous cell carcinoma cells by inhibiting Wnt/β-catenin signaling pathway.
TRIM36 is a novel androgen-responsive gene, and it dramatically enhanced the efficacy of anti-androgen drugs against prostate cancer.
Title: TRIM36, a novel androgen-responsive gene, enhances anti-androgen efficacy against prostate cancer by inhibiting MAPK/ERK signaling pathways.
Results suggest that high expression of TRIM36 is associated with favorable prognosis and that TRIM36 plays a tumor-suppressive role by inhibiting cell proliferation and migration as well as promoting apoptosis in prostate cancer.
Title: Androgen-responsive tripartite motif 36 enhances tumor-suppressive effect by regulating apoptosis-related pathway in prostate cancer.
aberrant hypermethylation of TRIM36 might be involved in the acquisition of malignant phenotype and could be served as a biomarker for risk assessment of PAHs exposure
Title: (TRIM36 hypermethylation is involved in polycyclic aromatic hydrocarbons-induced cell transformation).
The siRNA knock down of TRIM36 in HeLa and LN229 cells also led to reduced cell proliferation and increased apoptosis. We suggest that microtubule disruption and disorganized spindles mediated by mutant TRIM36 affect neural cell proliferation during neural tube formation, leading to Anencephaly .
Title: A homozygous mutation in TRIM36 causes autosomal recessive anencephaly in an Indian family.
TRIM36 is the causative gene for autosomal recessive anencephaly
Title: A homozygous mutation in TRIM36 causes autosomal recessive anencephaly in an Indian family.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Anencephaly 1 MedGen: C5561928 OMIM: 206500 GeneReviews: Not available	Compare labs

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Vif	vif	HIV-1 Vif downregulates the expression of tripartite motif containing 36 (TRIM36) in Vif-expression T cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

FB25G10 (e-PCR)
- UniSTS:66623

TRIM36 (e-PCR)
- UniSTS:504926

RH94386 (e-PCR)
- UniSTS:91548

G59597 (e-PCR)
- UniSTS:136901

RH92001 (e-PCR)
- UniSTS:91080

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables alpha-tubulin binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin-protein transferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin-protein transferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in acrosome reaction	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell cycle	IEA Inferred from Electronic Annotation more info
involved_in regulation of microtubule cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spindle organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in spindle organization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in acrosomal vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytosol	IDA Inferred from Direct Assay more info
located_in cytosol	TAS Traceable Author Statement more info
located_in plasma membrane	IDA Inferred from Direct Assay more info

General protein information

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Preferred Names: E3 ubiquitin-protein ligase TRIM36

Names: RING finger protein 98; RING-type E3 ubiquitin transferase TRIM36; tripartite motif protein 36; tripartite motif-containing protein 36; zinc-binding protein Rbcc728

NP_001017397.1

EC 2.3.2.27

NP_001017398.1

EC 2.3.2.27

NP_001287681.1

EC 2.3.2.27

NP_001287688.1

EC 2.3.2.27

NP_061170.2

EC 2.3.2.27

XP_016865110.1

EC 2.3.2.27

XP_016865111.1

EC 2.3.2.27

XP_016865112.1

EC 2.3.2.27

XP_047273316.1

EC 2.3.2.27

XP_047273317.1

EC 2.3.2.27

XP_047273318.1

EC 2.3.2.27

XP_054208879.1

EC 2.3.2.27

XP_054208880.1

EC 2.3.2.27

XP_054208881.1

EC 2.3.2.27

XP_054208882.1

EC 2.3.2.27

XP_054208883.1

EC 2.3.2.27

XP_054208884.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001017397.2 → NP_001017397.1 E3 ubiquitin-protein ligase TRIM36 isoform 2

See identical proteins and their annotated locations for NP_001017397.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks several 3' exons, but has a much shorter and alternate 3' segment, as compared to variant 1. The resulting isoform (2) has a much shorter and distinct C-terminus, as compared to isoform 1.

Source sequence(s)

BC046096

Consensus CDS

CCDS34211.1

UniProtKB/Swiss-Prot

Q9NQ86

Related

ENSP00000368938.2, ENST00000379618.6
NM_001017398.2 → NP_001017398.1 E3 ubiquitin-protein ligase TRIM36 isoform 3

See identical proteins and their annotated locations for NP_001017398.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks several 3' exons, but has a much shorter and alternate 3' segment, as compared to variant 1. The resulting isoform (3) has a much shorter and distinct C-terminus, as compared to isoform 1.

Source sequence(s)

AC008494, AI142389, BF592910

Consensus CDS

CCDS34212.1

UniProtKB/Swiss-Prot

Q9NQ86

Related

ENSP00000368937.2, ENST00000379617.2
NM_001300752.2 → NP_001287681.1 E3 ubiquitin-protein ligase TRIM36 isoform 4

Status: REVIEWED

Description

Transcript Variant: This variant (4) lacks an internal exon in the 5' region, which results in translation initiation at a downstream AUG start codon, compared to variant 1. The resulting isoform (4) has a shorter N-terminus, compared to isoform 1.

Source sequence(s)

AB196558, AC008494, AC094104, AJ272269

Consensus CDS

CCDS78047.1

UniProtKB/TrEMBL

E9PBG3, Q4R1Q4

Related

ENSP00000424259.1, ENST00000514154.1

Conserved Domains (4) summary

smart00060
Location:276 → 336

FN3; Fibronectin type 3 domain

cd00021
Location:56 → 94

BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.

cd12894
Location:360 → 563

SPRY_PRY_TRIM36; PRY/SPRY domain in tripartite motif-containing protein 36 (TRIM36)

cl23765
Location:101 → 225

iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
NM_001300759.2 → NP_001287688.1 E3 ubiquitin-protein ligase TRIM36 isoform 5

Status: REVIEWED

Description

Transcript Variant: This variant (5) has an alternate 5' terminal exon, compared to variant 1. The resulting isoform (5) is shorter and has a distinct N-terminus, compared to isoform 1.

Source sequence(s)

AC094104, AJ272269, AK296389, AK316422

Consensus CDS

CCDS75287.1

UniProtKB/Swiss-Prot

Q9NQ86

Related

ENSP00000423934.1, ENST00000513154.6

Conserved Domains (5) summary

smart00060
Location:419 → 479

FN3; Fibronectin type 3 domain

cd00021
Location:199 → 237

BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.

pfam13445
Location:21 → 49

zf-RING_UBOX; RING-type zinc-finger

cd12894
Location:503 → 706

SPRY_PRY_TRIM36; PRY/SPRY domain in tripartite motif-containing protein 36 (TRIM36)

cl23765
Location:244 → 368

iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
NM_018700.4 → NP_061170.2 E3 ubiquitin-protein ligase TRIM36 isoform 1

See identical proteins and their annotated locations for NP_061170.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AC008494, AC094104, AJ272269

Consensus CDS

CCDS4115.1

UniProtKB/Swiss-Prot

A1L3Z1, A6NDD0, B7Z3V4, B7ZAV7, E9PFI8, Q0P5Z9, Q9NQ86

Related

ENSP00000282369.3, ENST00000282369.7

Conserved Domains (5) summary

smart00060
Location:431 → 491

FN3; Fibronectin type 3 domain

cd00021
Location:211 → 249

BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.

pfam13445
Location:33 → 61

zf-RING_UBOX; RING-type zinc-finger

cd12894
Location:515 → 718

SPRY_PRY_TRIM36; PRY/SPRY domain in tripartite motif-containing protein 36 (TRIM36)

cl23765
Location:256 → 380

iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000005.10 Reference GRCh38.p14 Primary Assembly

Range

115124772..115180294 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017009621.3 → XP_016865110.1 E3 ubiquitin-protein ligase TRIM36 isoform X1
XM_017009622.3 → XP_016865111.1 E3 ubiquitin-protein ligase TRIM36 isoform X2
XM_047417360.1 → XP_047273316.1 E3 ubiquitin-protein ligase TRIM36 isoform X3
XM_047417361.1 → XP_047273317.1 E3 ubiquitin-protein ligase TRIM36 isoform X4

UniProtKB/TrEMBL

E9PBG3
XM_017009623.3 → XP_016865112.1 E3 ubiquitin-protein ligase TRIM36 isoform X5
XM_047417362.1 → XP_047273318.1 E3 ubiquitin-protein ligase TRIM36 isoform X6