fgf20a fibroblast growth factor 20a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: fgf20aprovided by ZNC
Official Full Name: fibroblast growth factor 20aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-060110-1
See related: Ensembl:ENSDARG00000007356 AllianceGenome:ZFIN:ZDB-GENE-060110-1
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: dob; wu:fb05c08
Summary: Predicted to enable fibroblast growth factor receptor binding activity and growth factor activity. Acts upstream of or within anatomical structure homeostasis; fin regeneration; and regulation of bone remodeling. Predicted to be located in extracellular region. Predicted to be active in cytoplasm and extracellular space. Is expressed in caudal fin; dermatocranium; inter-frontal joint; and kidney. Human ortholog(s) of this gene implicated in renal agenesis. Orthologous to human FGF20 (fibroblast growth factor 20). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 1

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	1	NC_007112.7 (16392410..16394473, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	1	NC_007112.6 (15700186..15701443, complement)

Chromosome 1 - NC_007112.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The evidence presented here indicates that fgf20a is important for normal mid-facial and calvarial growth and homeostasis in zebrafish, and that a key aspect of its influence on skull morphogenesis is the regulation of osteoblast and osteoclast activity during craniofacial remodeling.
Title: Deficiency of zebrafish fgf20a results in aberrant skull remodeling that mimics both human cranial disease and evolutionarily important fish skull morphologies.
Data indicate that fgf20a, fgf24, FGF receptor fgfr1 are expressed in normal and regenerating barbel tissue.
Title: Divergent requirements for fibroblast growth factor signaling in zebrafish maxillary barbel and caudal fin regeneration.
Hdac1 is required for expression of erm and fgf20a in rhombomeres; Hdac1-dependent expression of these two genes is attenuated in rhombomere boundary regions by Notch signalling activity
Title: Opposing actions of histone deacetylase 1 and Notch signalling restrict expression of erm and fgf20a to hindbrain rhombomere centres during zebrafish neurogenesis.
fgf20a is expressed in the intact fin and is required for homeostasis.
Title: Fgfs control homeostatic regeneration in adult zebrafish fins.
fgf20a has a regeneration-specific requirement, initiating fin regeneration, and controlling blastema formation
Title: fgf20 is essential for initiating zebrafish fin regeneration.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables fibroblast growth factor receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables growth factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables growth factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within anatomical structure homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in animal organ morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in fibroblast growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within fin regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of protein phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of bone remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell migration	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: fibroblast growth factor 20a

Names: devoid of blastema

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.