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    PAS1 FKBP-type peptidyl-prolyl cis-trans isomerase family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 824568, updated on 15-Oct-2023

    Summary

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    Gene symbol
    PAS1
    Gene description
    FKBP-type peptidyl-prolyl cis-trans isomerase family protein
    Primary source
    Araport:AT3G54010
    Locus tag
    AT3G54010
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    DEI1; PASTICCINO 1
    Summary
    Immunophilin-like protein similar to the p59 FK506-binding protein (FKBP52). Shows rotamase activity and contains an FKBP-like domain and three tetratricopeptide repeat units. Members of this class of mutation show ectopic cell proliferation in cotyledons. Gene may be alternatively spliced. Belongs to one of the 36 carboxylate clamp (CC)-tetratricopeptide repeat (TPR) proteins (Prasad 2010, Pubmed ID: 20856808) with potential to interact with Hsp90/Hsp70 as co-chaperones.
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    Genomic context

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    Location:
    chromosome: 3
    Exon count:
    20
    Sequence:
    Chromosome: 3; NC_003074.8 (20000821..20005280)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene Adenine nucleotide alpha hydrolases-like superfamily protein Neighboring gene TIP41-like protein Neighboring gene Inositol phosphorylceramide synthase 1 Neighboring gene kinase with tetratricopeptide repeat domain-containing protein Neighboring gene PAR1 protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Very-long-chain fatty acids are involved in polar auxin transport and developmental patterning in Arabidopsis. Roudier F, et al. Plant Cell, 2010 Feb. PMID 20145257, Free PMC Article
    2. Mutation in the Arabidopsis PASTICCINO1 gene, which encodes a new FK506-binding protein-like protein, has a dramatic effect on plant development. Vittorioso P, et al. Mol Cell Biol, 1998 May. PMID 9566922, Free PMC Article
    3. The C terminus of the immunophilin PASTICCINO1 is required for plant development and for interaction with a NAC-like transcription factor. Smyczynski C, et al. J Biol Chem, 2006 Sep 1. PMID 16803883
    4. The PASTICCINO genes of Arabidopsis thaliana are involved in the control of cell division and differentiation. Faure JD, et al. Development, 1998 Mar. PMID 9449673
    5. Arabidopsis immunophilin-like TWD1 functionally interacts with vacuolar ABC transporters. Geisler M, et al. Mol Biol Cell, 2004 Jul. PMID 15133126, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PAS1 regulates the function of the NAC-like transcription factor by controlling its targeting to the nucleus upon plant cell division
      Title: The C terminus of the immunophilin PASTICCINO1 is required for plant development and for interaction with a NAC-like transcription factor.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_115261.4
    NM_180370.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables peptidyl-prolyl cis-trans isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within embryo development ending in seed dormancy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within embryonic pattern specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within establishment of cell polarity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within lateral root development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to cytokinin IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within root development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within unidimensional cell growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within very long-chain fatty acid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    FKBP-type peptidyl-prolyl cis-trans isomerase family protein
    NP_566993.1
    • PASTICCINO 1 (PAS1); FUNCTIONS IN: FK506 binding, peptidyl-prolyl cis-trans isomerase activity, binding; INVOLVED IN: in 9 processes; LOCATED IN: endoplasmic reticulum, nucleus; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Tetratricopeptide-like helical (InterPro:IPR011990), Tetratricopeptide repeat-containing (InterPro:IPR013026), Tetratricopeptide repeat (InterPro:IPR019734), Peptidyl-prolyl cis-trans isomerase, FKBP-type (InterPro:IPR001179); BEST Arabidopsis thaliana protein match is: rotamase FKBP 1 (TAIR:AT3G25230.2); Has 6940 Blast hits to 5854 proteins in 534 species: Archae - 36; Bacteria - 500; Metazoa - 3344; Fungi - 737; Plants - 1066; Viruses - 0; Other Eukaryotes - 1257 (source: NCBI BLink).
    NP_850701.1
    • PASTICCINO 1 (PAS1); FUNCTIONS IN: FK506 binding, peptidyl-prolyl cis-trans isomerase activity, binding; INVOLVED IN: in 9 processes; LOCATED IN: endoplasmic reticulum, nucleus; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Tetratricopeptide-like helical (InterPro:IPR011990), Tetratricopeptide repeat-containing (InterPro:IPR013026), Tetratricopeptide repeat (InterPro:IPR019734), Peptidyl-prolyl cis-trans isomerase, FKBP-type (InterPro:IPR001179); BEST Arabidopsis thaliana protein match is: rotamase FKBP 1 (TAIR:AT3G25230.2); Has 6249 Blast hits to 5494 proteins in 451 species: Archae - 36; Bacteria - 312; Metazoa - 2945; Fungi - 683; Plants - 1187; Viruses - 0; Other Eukaryotes - 1086 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      20000821..20005280
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_115261.4 → NP_566993.1  FKBP-type peptidyl-prolyl cis-trans isomerase family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_566993.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O64403, Q7DMA9, Q93ZT7, Q9M326
      UniProtKB/TrEMBL
      A0A5S9XLE3, A0A7G2ER31
      Conserved Domains (4) summary
      sd00006
      Location:437 → 478
      TPR; TPR repeat [structural motif]
      pfam00254
      Location:44 → 144
      FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
      pfam13414
      Location:399 → 480
      TPR_11; TPR repeat
      cl19519
      Location:168 → 257
      FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase

    2. NM_180370.3 → NP_850701.1  FKBP-type peptidyl-prolyl cis-trans isomerase family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_850701.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9XLE3, A0A7G2ER31
      Conserved Domains (4) summary
      sd00006
      Location:347 → 388
      TPR; TPR repeat [structural motif]
      pfam00254
      Location:201 → 290
      FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
      pfam13414
      Location:309 → 390
      TPR_11; TPR repeat
      cl19519
      Location:1 → 54
      FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7DMA9.2

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