Conserved Protein Domain Family
DOPA_deC_like

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cd06450: DOPA_deC_like 
Click on image for an interactive view with Cn3D
DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and glutamate decarboxylase (GDC). DDC is active as a dimer and catalyzes the decarboxylation of tyrosine. GDC catalyzes the decarboxylation of glutamate and HDC catalyzes the decarboxylation of histidine.
Statistics
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PSSM-Id: 99743
View PSSM: cd06450
Aligned: 40 rows
Threshold Bit Score: 312.6
Threshold Setting Gi: 6320500
Created: 30-Jun-2008
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
catalyticpyridoxal
Conserved site include 1 residue -Click on image for an interactive view with Cn3D
Feature 1:catalytic residue [active site]
Evidence:
  • Comment:pyridoxal 5'-phosphate (PLP) forms an internal aldimine bond (Schiff base linkage) with the catalytic residue lysine
  • Structure:1JS6_A; catalytic residue (lys) and cofactor (PLP)
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                       
1JS6_A       76 FFAYfpta--ssypAMLADMLcgaigcigfs--waaspacteLETVMMDWLGKMlqlpeaflageagegGGVIQGsASEA 151
gi 10129683 144 RASGtvys--geekLTELLVKaygdfawsnplhpdifpglrkIEAEIVRIACSLfngg--------pdsCGCVTSgGTES 213
gi 20090797  67 NLASfvntw-mepeADKLVMEniskniidi---feypqtsrvIHHNMVNMLGRLfngh-------htdfVGTSTAgSSEA 135
gi 21355963 132 RVSGavyg--ykpdLVELVTEvygkasytnplhadlfpgvckMEAEVVRMACNLfhgn--------sasCGTMTTgGTES 201
gi 17543922 138 RVSGavytd-rhaeHINLLGKiyekyafsnplhpdvfpgarkMEAELIRMVLNLyngp--------edsSGSVTSgGTES 208
gi 18376029 146 YVSGavys--gedeLLKLQTEaygkftvanpihpdvfpgvrkMEAEVVAMVLSLfnap--------pgaAGVSTSgGTES 215
gi 6320500  168 KVSGavyh--ggddLIHLQTIayekycvanqlhpdvfpavrkMESEVVSMVLRMfnap-------sdtgCGTTTSgGTES 238
gi 30908928 116 KVSGcvyl--gekeHTKLLNEayslfslsnplhpsvfpsirkFETESISMVSNMlnah--------skvVGSLTSgGTES 185
gi 15229517  58 NLASfvttw-mepeCDKLIMDsvnknyvdm----deypvtteLQNRCVNMIANLfhapvg----edeaaIGCGTVgSSEA 128
gi 17557272 130 RVSGavfnreddkdEREMYEEvfgkfawtnplwpklfpgvriMEAEVVRMCCNMmngd--------setCGTMSTgGSIS 201
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                       
1JS6_A      152 TLVALLAArtkvvrrlqaaspgltqgavleklVAYASdqAHSSVERAGLiggvKLKAIpsdgkf-amrasALQEALerdk 230
gi 10129683 214 ILMACKAYrdlafe------------kgiktpEIVAPqsAHAAFNKAASyfgmKIVRVpltkmm-evdvrAMRRAIsr-- 278
gi 20090797 136 IMLGLLAHkwswkks----------grgtdkpNIIFGndAHVCWDKFARyfdvDTRKVpidkdrrtitaeAVAERIde-- 203
gi 21355963 202 IVMAMKAYrdfarey-----------kgitrpNIVVPktVHAAFDKGGQyfniHVRSVdvdpetyevdikKFKRAInr-- 268
gi 17543922 209 IIMACFSYrnrahs------------lgiehpVILACktAHAAFDKAAHlcgmRLRHVpvdsdn-rvdlkEMERLIds-- 273
gi 18376029 216 ILMAILSArqkayhe-----------rgvtepEMIIPetAHTAFRKAAEyfniKLHLVacpaptyqvdtkRVARLInr-- 282
gi 6320500  239 LLLACLSAkmyalhh-----------rgitepEIIAPvtAHAGFDKAAYyfgmKLRHVeldpttyqvdlgKVKKFInk-- 305
gi 30908928 186 IFMAVKAYrdfykd-------------rtdrpEIVVPvtIHAAFDKACEylkiRIVHIdvgpvsykvdmaAMKKAInk-- 250
gi 15229517 129 IMLAGLAFkrkwqhrrk------aqglpidkpNIVTGanVQVCWEKFARyfevELKEVklsedyyvmdpaKAVEMVde-- 200
gi 17557272 202 ILLACLAHrnrllkr-----------gekyteMIVPSsvHAAFFKAAECfr-iKVRKIpvdpvtfkvdlvKMKAAInk-- 267
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                       
1JS6_A      231 aagliPFFVVATLGTTsccsfdnLLEVGPICHee------dIWLHVDAAYAGSAFicpefrhl------lngvefaDSFN 298
gi 10129683 279 ----nTAMLVCSTPQFphgvidpVPEVAKLAVky------kIPLHVDACLGGFLIvfmekagyplehpfdfrvkgvTSIS 348
gi 20090797 204 ----nTICVGCVLGTTftgeidpVKDINDLLLeykeekgwdIPIHIDAASGGFILpftepdfe-----wdfrlervKSIN 274
gi 21355963 269 ----nTILLVGSAPNFpygtiddIEAIAALGVky------dIPVHVDACLGSFVValvrnagykl-rpfdfevkgvTSIS 337
gi 17543922 274 ----nVCMLVGSAPNFpsgtidpIPEIAKLGKky------gIPVHVDACLGGFMIpfmndagyli-pvfdfrnpgvTSIS 342
gi 18376029 283 ----nTIMLVGSAPNFphgiiddISALSKLALrk------kIPLHVDCCLGSFLVpfldkagfds-qpfdfrlkgvTSIS 351
gi 6320500  306 ----nTILLVGSAPNFphgiaddIEGLGKIAQky------kLPLHVDSCLGSFIVsfmekagyknlplldfrvpgvTSIS 375
gi 30908928 251 ----dTILVAGSAVNFphgiidpIDEIAKLAQqy------dIGCHVDACLGGFILpfaekldydi-pvfdfripgvTSMS 319
gi 15229517 201 ----nTICVAAILGSTltgefedVKQLNDLLAeknaetgweTPIHVDAASGGFIApflypdle-----wdfrlpwvKSIN 271
gi 17557272 268 ----rTCMLVGSAPNFpfgtvddIEAIGQLGLey------dIPVHVDACLGGFLLpfleedeir----ydfrvpgvSSIS 333
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1           #                                                                           
1JS6_A      299 FNPHKWLLVnfDCSAMWVKrrtdltgafkldpvylkhshqgsglitdyrhwqlplgrrfrSLKMWFVFRmygvkglQAYI 378
gi 10129683 349 ADTHKYGYApkGSSLVLYSdkkyrnyqffvdtdwqg--------giyasptiagsrpggiSAAAWAALMhfgengyVEAT 420
gi 20090797 275 VSGHKYGLTypGLGWLIFRnknalpedlifhvnylg--------emedsytlnfsggsamVAAQYYNFLrfgragyTGIM 346
gi 21355963 338 ADTHKYGFApkGSSVILYSdkkykdhqftvttdwpg--------gvygsptvngsraggiIAACWATMMsfgydgyLEAT 409
gi 17543922 343 CDTHKYGCTpkGSSIVMYRskelhhfqyfsvadwcg--------giyatptiagsraganTAVAWATLLsfgrdeyVRRC 414
gi 18376029 352 CDTHKYGFApkGNSTVLYRtaelrsyqyfvdpswsg--------gvyaspgiagsrpgalIAACWASLMsvgeegyLKSC 423
gi 6320500  376 CDTHKYGFApkGSSVIMYRnsdlrmhqyyvnpawtg--------glygsptlagsrpgaiVVGCWATMVnmgengyIESC 447
gi 30908928 320 VDTHKFGYAakGTSVVLFGnkklrramyfvapnwpg--------giyasptlpgsrpgglVAACWASLVsmgndgfLEKA 391
gi 15229517 272 VSGHKYGLVyaGVGWVVWRtkddlpeelvfhinylg--------adqptftlnfskgssqIIAQYYQFIrlgfegyKNIM 343
gi 17557272 334 ADSHKYGLApkGSSVVLYRnkellhnqyfcdadwqg--------giyasatmegsraghnIALCWAAMLyhaqegyKANA 405
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                       
1JS6_A      379 RKHVQLSHEFEAfvlqdprf-evcaevtlGLVCFRlkgs--dglNEALLERINsarkIHLVPCrlr----gqfVLRFAIC 451
gi 10129683 421 KQIIKTARFLKSelenikgi-fvfgnpqlSVIALGsrd----fdIYRLSNLMTak-gWNLNQLqf------ppSIHFCIT 488
gi 20090797 347 KKILAVSQDLAEkvdrlgrfemlnkgerlPIIAFRqkek-tgysLLQLSHKLRek-gWIVPAYclpenaadieIMRIVVR 424
gi 21355963 410 KRIVDTARYIERgvrdidgi-fifgkpatSVIALGsnv----fdIFRLSDSLCkl-gWNLNALqf------psGIHLCVT 477
gi 17543922 415 AQIVKHTRMLAEkiekikwi-kpygksdvSLVAFSgng----vnIYEVSDKMMkl-gWNLNTLqn------paAIHICLT 482
gi 18376029 424 TQIVGATKKLAEhirshptlqqeleilgnPLVSVLafqargdlnIYDIADGMSsr-gWHLNALqn------ppAIHVAVT 496
gi 6320500  448 QEIVGAAMKFKKyiqenipdlnimgnprySVISFSskt----lnIHELSDRLSkk-gWHFNALqk------pvALHMAFT 516
gi 30908928 392 KGVMETTKKIIKglqsingv-kiigdpkaMVVAFTcd------nIFYVNDYMSkk-gWHLNALqr------pnSLHVCVT 457
gi 15229517 344 ENCMDNARRLREgiemtgkfnivskdigvPLVAFSlkds-skhtVFEIAESLRkf-gWIIPAYtmpadaqhiaVLRVVIR 421
gi 17557272 406 RKIVDTTRKIRNglsnikgi-klqgpsdvCIVSWTtnd---gveLYRFHNFMKek-hWQLNGLqf------paGVHIMVT 474
                       410
                ....*....|....*....
Feature 1                          
1JS6_A      452 srkvesGHVRLAWEHIRGL 470
gi 10129683 489 llharkRVAIQFLKDIRES 507
gi 20090797 425 enl-tpDMASIIVEDLEKA 442
gi 21355963 478 dmhtqpGVADKFIADVRSC 496
gi 17543922 483 inqaneEVVNAFAVDLEKI 501
gi 18376029 497 ap--vaKNWERLAQDLEGV 513
gi 6320500  517 rl--saHVVDEICDILRTT 533
gi 30908928 458 ak--miGMESLFIEDLKDS 474
gi 15229517 422 edf-srGLADRLITHIIQV 439
gi 17557272 475 mnhthpGLAEAFVADCRAA 493

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