Conserved Protein Domain Family
P-type_ATPase_cation
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cd07542: P-type_ATPase_cation 
P-type cation-transporting ATPases, similar to human ATPase type 13A2 (ATP13A2) protein and Saccharomyces cerevisiae Ypk9p
Saccharomyces cerevisiae Yph9p localizes to the yeast vacuole and may play a role in sequestering heavy metal ions, its deletion confers sensitivity for growth for cadmium, manganese, nickel or selenium. Human ATP13A2 (PARK9/CLN12) is a lysosomal transporter with zinc as the possible substrate. Mutation in the ATP13A2 gene has been linked to Parkinson's disease and Kufor-Rakeb syndrome, and to neuronal ceroid lipofuscinoses. ATP13A3/AFURS1 is a candidate gene for oculo auriculo vertebral spectrum (OAVS), being one of nine genes included in a 3q29 microduplication in a patient with OAVS. Mutation in the human ATP13A4 may be involved in a speech-language disorder. This subfamily also includes zebrafish ATP13A2 a lysosome-specific transmembrane ATPase protein of unknown function which plays a crucial role during embryonic development, its deletion is lethal. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.
Links
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Statistics
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PSSM-Id: 319842
Aligned: 16 rows
Threshold Bit Score: 1035.28
Created: 19-May-2008
Updated: 2-Oct-2020
Structure
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Aligned Rows:
Download Cn3D
 
Feature 1: P-type ATPase signature motif, 7 residue positions
Conserved feature residue pattern:D K [TS] G T [LIVM] [TS]Click to see conserved feature residue pattern help
Evidence:
  • Comment:a characteristic P-type ATPase conserved sequence motif: DK[TS]GT[LIV]T, in which D is the reversibly phosphorylated Asp
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                         
Q9H7F0        182 GMHAYRKLLYGVNEIAVKVPSVFKLLIKEVLNPFYIFQLFSVILWSTDEYYYYALAIVVMSIVSIVSSLYsirkqyvmlh 261  human
Q27533        158 SEISRRLEFYGRNEIVVQLRPILYLLVMEVITPFYVFQIFSVTVWYNDEYAYYASLIVILSLGSIVMDVYqirtqei--r 235  nematode
CAD70973      331 DEKSHRDAVFGGNLIDIEEKSTFRLLADEVFHPFYVFQIASLILWSVDEYYYYAIAIFVMSVGSIVATLIetkstmk--r 408  Neurospora cr...
NP_001096849  326 HEQISRRIVFGDNEITVPLRDFKTLLFLEVLNPFYVFQLFSVILWFTYDYYYYACVILLMSVFGITVSVLqtkknqd--v 403  fruit fly
NP_001023542  189 DDVALRRTYFGPNVMPVKLSPFYELVYKEVLSPFYIFQAISVTVWYIDDYVWYAALIIVMSLYSVIMTLRqtrsqqr--r 266  nematode
EAL21261      579 AVRKQRLVLMGENIIDIASKSVVGLLVDEVLHPFYVFQIASIILWSLDDYYYYAFAIALISITSIMSTLIetkrtie--r 656  Cryptococcus ...
NP_001024768  194 QDVIASRKIYNMNALALALTPILVILFKEVLGPFYLFQCFSVALWYSDNYAYYASVIVIITVGSAAVAVYqmraqek--r 271  nematode
Q04956         12 KLINDRKILYGECNLNIKSDSFIILLFKEIMNPFFIFQIFAMIVWSLDNYIEYTISILFITSISIILELKntiknqk--k 89   malaria paras...
O74431        301 DAINDRLCIFGENLIDLELKSVSQLLIDEVLHPFYIFQVFSIILWSMDSYYYYAICILIISVVSILGSLIetrktlr--r 378  Schizosacchar...
Q12697        465 GVQEDRELAFGKNQINLRMKTTSEILFNEVLHPFYVFQVFSIILWGIDEYYYYAACIFLISVLSIFDSLNeqkkvsr--n 542  Saccharomyces...

Feature 1                                                                                         
Q9H7F0        262 dmvathSTVRVSVCRvnEEIEEIFSTDLVPGDVMVIpl-nGTIMPCDAVLINGTCIVNESMLTGESVPVTKTNLpnpsvd 340  human
Q27533        236 lrsmvhSTESVEVIRe-GTEMTIGSDQLVPGDILLIpp-hGCLMQCDSVLMNGTVIVNESVLTGESVPITKVALtdetnd 313  nematode
CAD70973      409 lreisrFVCDVRVLRn-GFWRHVSSSDLVPGDIYEVsdpsLSQFPADSLLLGGDCIVNESMLTGESVPVSKTPAtdqslr 487  Neurospora cr...
NP_001096849  404 lqktvyNTGNAWVVDhkGLSKELPTRAIVPGDIIEIps-sGCTLHCDAILISGNCILDESMLTGESVPVTKTPLpskrdm 482  fruit fly
NP_001023542  267 lqsmvvEHDEVQVIRenGRVLTLDSSEIVPGDVLVIpp-qGCMMYCDAVLLNGTCIVNESMLTGESIPITKSAIsddghe 345  nematode
EAL21261      657 mremsrFHCDIKVLId-GEWVMKDCSELVPGDIFDSsdpnLSVFPCDALLLSGDAIVNESMLTGESVPVSKIPAkdetlr 735  Cryptococcus ...
NP_001024768  272 irnmvgDTISVIVRRd-GHDITIDASEIVPMDILILps-nTFILPCDCLLMNGTVIVNEAMLTGESVPVTKASLkeadec 349  nematode
Q04956         90 iknmlnYTCPINVYRy-NTSYIISSSELVPGDIYEIk--nNMTIPCDTIILSGSVTMSEHMLTGESVPIHKERLpfegna 166  malaria paras...
O74431        379 mremsrFTCPVRVYRd-GFWTSISSTDLVIGDVFEIsdpeLTIFPADALLLSGDCIVNESMLTGESIPVSKIPAtdqsmk 457  Schizosacchar...
Q12697        543 laemshFHCDVRVLRd-KFWTTISSSELVPGDIYEVsdpnITILPCDSILLSSDCIVNESMLTGESVPVSKFPAteetmy 621  Saccharomyces...

Feature 1                                                                                         
Q9H7F0        341 vkgi---------------------------------------------------------------------------- 344  human
Q27533        314 s------------------------------------------------------------------------------- 314  nematode
CAD70973      488 nldl---------------------------------------------------------------------------- 491  Neurospora cr...
NP_001096849  483 i------------------------------------------------------------------------------- 483  fruit fly
NP_001023542  346 k------------------------------------------------------------------------------- 346  nematode
EAL21261      736 alsres-------------------------------------------------------------------------- 741  Cryptococcus ...
NP_001024768  350 gp------------------------------------------------------------------------------ 351  nematode
Q04956        167 iinknnkydsndekddylriynnhasinmikrnhlieetlgkkdreyksnthdlcsmnklcyinntyddvhmknnkmdyn 246  malaria paras...
O74431        458 elfs---------------------------------------------------------------------------- 461  Schizosacchar...
Q12697        622 qlcdd--------------------------------------------------------------------------- 626  Saccharomyces...

Feature 1                                                                                         
Q9H7F0            --------------------------------------------------------------------------------      human
Q27533            --------------------------------------------------------------------------------      nematode
CAD70973          --------------------------------------------------------------------------------      Neurospora cr...
NP_001096849      --------------------------------------------------------------------------------      fruit fly
NP_001023542      --------------------------------------------------------------------------------      nematode
EAL21261          --------------------------------------------------------------------------------      Cryptococcus ...
NP_001024768      --------------------------------------------------------------------------------      nematode
Q04956        247 nnnnnkkkkkinnlnfvkgtyinsndllyddkigvnifeddvnnmkhkfnqrninyynkdtnnleynnkhryiydcllkk 326  malaria paras...
O74431            --------------------------------------------------------------------------------      Schizosacchar...
Q12697            --------------------------------------------------------------------------------      Saccharomyces...

Feature 1                                                                                         
Q9H7F0        345 -------gdelynpethKRHTLFCGTTVIQtrf---------ytGELVKAIVVRTGFSTSKGQLVRSILYPKPTDFKLYR 408  human
Q27533        315 ----------vfnieknSKNVLFCGTQVLQtrf---------yrGKKVKAIVLRTAYSTLKGQLVRSIMYPKPVDFRFTK 375  nematode
CAD70973      492 --------gastvlpevAKHFLFCGTKIIRarrpq----ddhneEAVALALVVRTGFNTTKGALVRSMLFPKPSGFKFYR 559  Neurospora cr...
NP_001096849  484 -----------fdktehARHTLFCGTKVIQtry---------igSKKVLAFVINTGNITAKGELIRSILYPPPVDYKFEQ 543  fruit fly
NP_001023542  347 ----------ifsidkhGKNIIFNGTKVLQtky---------ykGQNVKALVIRTAYSTTKGQLIRAIMYPKPADFKFFR 407  nematode
EAL21261      742 ------kqgsseidsdlAKHYLFSGTKIIRvragakpvwapkseSSIALAMVTRTGFNTTKGALVRSMLFPKPMGFKFYR 815  Cryptococcus ...
NP_001024768  352 ---------eirlssehNRHTLFSGTTVLQtrn---------ykGQPVMARVIRTGFSTLKGQLVRSIMYPKPQEKEALK 413  nematode
Q04956        327 veaisqknkiiysnediNKYMLYGGTYVLSlyninki-kynnkeENRILGLVIKTGFITTKGKIVNNILYHKKKELNLIN 405  malaria paras...
O74431        462 --------fsknipaslCKHFLFSGTKIIQvrkpf----vnekeEGASLAMVVRTGFNTTKGALVRSMIFPKPTNFSFYR 529  Schizosacchar...
Q12697        627 -------fqstqissfvSKSFLYNGTNIIRari--------apgQTAALAMVVRTGFSTTKGSLVRSMVFPKPTGFKFYR 691  Saccharomyces...

Feature 1                                                                                         
Q9H7F0        409 DAYLFLLCLVAVAGIGFIYTIINSILNEvqvgvIIIESLDIITITVPPALPAAMTAGIVYAQRRLKKi-GIFCISPQRIN 487  human
Q27533        376 DLFKFILFLACISGCGFIYTIIVMIMRGntlrrIIVRSLDIITITVPPALPAAMSVGIINAQLRLKKk-EIFCISPSTIN 454  nematode
CAD70973      560 DSFRYISVMACVAMVGFAASFVNFIRLNlswhlIIVRALDLITIVVPPALPATLTIGTNFALGRLKSk-KIFCISPQRVN 638  Neurospora cr...
NP_001096849  544 DSYKFIQFLAIIACVGFIYTLVTKILRGtdpvkIAVESLDLITIVVPPALPAAMTVGRFYAQKRLKTs-EIFCISPRSIN 622  fruit fly
NP_001023542  408 ELMKFIGVLAIVAFFGFMYTSFILFYRGssigkIIIRALDLVTIVVPPALPAVMGIGIFYAQRRLRQk-SIYCISPTTIN 486  nematode
EAL21261      816 DSMNFIGVLAIIAGFGFAISAVQFVRIGihwhtIMLRALDLITIVVPPALPATLTIGTTFAIDRLRKs-GIFCISPNRVN 894  Cryptococcus ...
NP_001024768  414 DVMVFILVLGFIALIGFIYTVIEMVSRGeslkhIIIRSLDIITIVVPPALPAAMSVGIINANSRLKKk-KIFCTSPTTVN 492  nematode
Q04956        406 DSYKFLIILIIYALFSVFILLYITLSNNeytnhIIIKCLDIITDAIPPALPTTLTVGISIAISRLKKkfSISCLCPHKIN 485  malaria paras...
O74431        530 DSFRFITAMFIIALIGFVFSSINLLTLGvpiatIIIRALDLITIVVPPALPATLTIGTTFAISRLRKq-GIFCISPQRVN 608  Schizosacchar...
Q12697        692 DSFKYIGFMSLIAIFGFCVSCVQFIKLGldkktMILRALDIITIVVPPALPATLTIGTNFALSRLKEk-GIFCISPTRLN 770  Saccharomyces...

Feature 1                   #######                                                               
Q9H7F0        488 ICGQLNLVCFDKTGTLTEDGLDLWGIQRVENARFLspeenvcne------------------------------------ 531  human
Q27533        455 TCGAINVVCFDKTGTLTEDGLDFHVVRPVMSAVNQeiqkvkleksnrtefmge--------------------------- 507  nematode
CAD70973      639 VGGKLDIMCFDKTGTLTEEGLDVLGVRVVDRTNNRfsdildnpddlvprqdh---------------------------- 690  Neurospora cr...
NP_001096849  623 VAGSINCCCFDKTGTLTEDGLDMWGVVPKSSTNQFqiplksvdr------------------------------------ 666  fruit fly
NP_001023542  487 TCGAIDVVCFDKTGTLTEDGLDFYALRVVNDAKIGdnivqiaan------------------------------------ 530  nematode
EAL21261      895 IGGKINVVCFDKTGTLTEDGLDVLGARTIDRQNSRfselhsdiadvpi-------------------------------- 942  Cryptococcus ...
NP_001024768  493 VCGLINVACFDKTGTLTEDGLDFNCLKAIRKNEDGkpeftsefeeldpv------------------------------- 541  nematode
Q04956        486 IAGQINTMVFDKTGTLTENNLQFIGIITQNKKNKNmlsdfihikemntesyihskddnmihnknsiiseyyikdnmknlh 565  malaria paras...
O74431        609 VSGKLDLISFDKTGTLTEDGLDIMGVSVIEGSELGdlrsnsgnlcskd-------------------------------- 656  Schizosacchar...
Q12697        771 ISGKIDVMCFDKTGTLTEDGLDVLGVQISEPNGVRgqkfgellsdirqvfpkf--------------------------- 823  Saccharomyces...

Feature 1                                                                                         
Q9H7F0            --------------------------------------------------------------------------------      human
Q27533            --------------------------------------------------------------------------------      nematode
CAD70973          --------------------------------------------------------------------------------      Neurospora cr...
NP_001096849      --------------------------------------------------------------------------------      fruit fly
NP_001023542      --------------------------------------------------------------------------------      nematode
EAL21261          --------------------------------------------------------------------------------      Cryptococcus ...
NP_001024768      --------------------------------------------------------------------------------      nematode
Q04956        566 tsskkksitkersnflvqtikscllkdhyikekkkeyytnntycndlhindstcssyllnsetkdayceyynidhlcdin 645  malaria paras...
O74431            --------------------------------------------------------------------------------      Schizosacchar...
Q12697            --------------------------------------------------------------------------------      Saccharomyces...

Feature 1                                                                                         
Q9H7F0            --------------------------------------------------------------------------------      human
Q27533            --------------------------------------------------------------------------------      nematode
CAD70973          --------------------------------------------------------------------------------      Neurospora cr...
NP_001096849      --------------------------------------------------------------------------------      fruit fly
NP_001023542      --------------------------------------------------------------------------------      nematode
EAL21261          --------------------------------------------------------------------------------      Cryptococcus ...
NP_001024768      --------------------------------------------------------------------------------      nematode
Q04956        646 kknmdinsknelmgkysknelmgktiknelmgkysknelmgkysknelmgkysknelmgkysknelmgkysknelmgkti 725  malaria paras...
O74431            --------------------------------------------------------------------------------      Schizosacchar...
Q12697            --------------------------------------------------------------------------------      Saccharomyces...

Feature 1                                                                                         
Q9H7F0        532 -------------------------------------------------------------------mlvksqfvaCMAT 544  human
Q27533        508 ----------------------------------------------------------mteltsrnglpfdgdlvkAIAT 529  nematode
CAD70973      691 ------------------------------------------------------------gtgirdssdtlkaalyTMAT 710  Neurospora cr...
NP_001096849  667 --------------------------------------------------------------------lpfdhflfGMVT 678  fruit fly
NP_001023542  531 --------------------------------------------------------------------dscqnvvrAIAT 542  nematode
EAL21261      943 ----------------------------------------------------------------eggvngktpllyALAT 958  Cryptococcus ...
NP_001024768  542 ---------------------------------------------------------------klsaenanlnivvAAAS 558  nematode
Q04956        726 knqvgvdtniyhmncdndynydypcdyncnncndtyhrleyhninkdnsfnippeknksynnisehikinypllfeALAC 805  malaria paras...
O74431        657 ----------------------------------------------------------------llsndspsnllyTMAT 672  Schizosacchar...
Q12697        824 ----------------------------------------------------------slndcsspldfksrnffmSLLT 845  Saccharomyces...

Feature 1                                                                                         
Q9H7F0        545 CHSLTKIEGVLSGDPLDLKMFEAIGWILEeateeetalhnrimptvvrppkql-----------------lpestpagnq 607  human
Q27533        530 CHSLTRINGVLHGDPLDLILFQKTGWTMEegiegdieeetqrfdnv--------------------------------qp 577  nematode
CAD70973      711 CHSLRSIDDELVGDPLDLKMFEFTRWSFEeghegggatdgeeqgtlqpsiarpp---------------tvdkgytdadr 775  Neurospora cr...
NP_001096849  679 CHSITILNGRMMGDPLDLKMFESTGWELEdsnnipdtekygilyptilrqprgglsgmaetesgskneikrqssvddlla 758  fruit fly
NP_001023542  543 CHTLSKINNELHGDPLDVIMFEQTGYSLEeddseshesiesiqp-----------------------------------i 587  nematode
EAL21261      959 CHALKLIDGEIIGDPLDIKMFEYTGWTLDegqsrpvtkgnaegarpqalvqtvvr-------------ppgtdrwrmeda 1025 Cryptococcus ...
NP_001024768  559 CHSLTRIDGTLHGDPLELILVEKSKWIIEeavnsdeetqdfdtvqptv----------------------------lrpp 610  nematode
Q04956        806 CHTLSKVNNKIMGDVLEILMFNFTNCDMLinnnsfiikekkkncsydfqkid--------------------gdknigan 865  malaria paras...
O74431        673 CHMLRYVDGELVGDPLDIKMFKFTHWSYSeenflnkkmsseqaedaayvrtqql----------------ipptvsppwn 736  Schizosacchar...
Q12697        846 CHSLRSVDGNLLGDPLDFKMFQFTGWSFEedfqkrafhslyegrheddvfpensei------------ipavvhpdsnnr 913  Saccharomyces...

Feature 1                                                                                         
Q9H7F0        608 emelfelpatyeigIVRQFPFSSALQRMSVVARvlg---------------------------------------drkMD 648  human
Q27533        578 siikptddksaeysVIRQFTFSSSLQRMSVIVFdpred------------------------------------rpdnMM 621  nematode
CAD70973      776 qdatqngrapfelgVLKSFEFVSQLRRASVIVKtfg---------------------------------------qksGD 816  Neurospora cr...
NP_001096849  759 tvgispsqknfdhgIVREFPFTSALQRMSVVTRcls---------------------------------------dqvFN 799  fruit fly
NP_001023542  588 lirppkdsslpdcqIVKQFTFSSGLQRQSVIVTee-----------------------------------------dsMK 626  nematode
EAL21261     1026 lkqgskhahflelgVIRTFDFVSALRRMSVIVKrlk---------------------------------------stcME 1066 Cryptococcus ...
NP_001024768  611 peqatyhpenneysVIKQHPFNSALQRMSVIIStpseh------------------------------------sahdMM 654  nematode
Q04956        866 derchlnnnlvsynILKRFEFQSRLQRMSVIVKstygnnnddnndddnnndddnnddnnnddnnnddnnddnnnnnyyYN 945  malaria paras...
O74431        737 spsnnytesdlelgIVRTFEFVSQLRRMAVIVKhgk---------------------------------------fkkMD 777  Schizosacchar...
Q12697        914 entftdndphnflgVVRSFEFLSELRRMSVIVKtnn---------------------------------------ddvYW 954  Saccharomyces...

Feature 1                                                                                         
Q9H7F0        649 AYMKGAPEAIaglCKPETVPVDFQNVLEDFTKQGFRVIALAHRKLeskltwhkvqnisrdaIENNMDFMGLIIMQNKLKQ 728  human
Q27533        622 LYSKGSPEMIlslCDPNTVPEDYLLQVNSYAQHGFRLIAVARRPLdlnfnka--skvkrdaVECDLEMLGLIVMENRVKP 699  nematode
CAD70973      817 IFVKGAPECMrdiCKPESFPADYDDQLNYYTHKGYRVIGCATKHIpklswvka-qkmtrhnVESDLDFVGFIIFENKLKP 895  Neurospora cr...
NP_001096849  800 VYCKGSPEMLkklCKPQSLPDNYSQQLSEFAKKGYRIIAIAFKALshkmnytkvqrlsreeVENNMEFLGFVILENRLKP 879  fruit fly
NP_001023542  627 AYCKGSPEMImslCRPETVPENFHDIVEEYSQHGYRLIAVAEKELvvgsevq---ktprqsIECDLTLIGLVALENRLKP 703  nematode
EAL21261     1067 VYVKGAPEVMpeiCDPSSFPHDYDDMLSYYTRNGFRVIAIAGKSIegltwlra-qrmrrdvAESDLQFLGFIVFENKLKP 1145 Cryptococcus ...
NP_001024768  655 VFTKGSPEMIaslCIPDTIPEDYMEVVDEYAQRGFRLIAVASKAVhlnfaka--lktprdiMESELEFLGLIVMENRLKD 732  nematode
Q04956        946 IFCKGSPEKIkelCLKSKIPNNYDEILNKYTKQGMRILSISYKRVkskninl--lnvkrsfVESNLHFLGFLIFTNNMKK 1023 malaria paras...
O74431        778 AYVKGAPEIMpsiCKPESFPANYQEVLDYYTHNGFRVIACASKQLenctwaka-qrmkreqVECDLDFCGFIVFENKLKS 856  Schizosacchar...
Q12697        955 SFTKGAPEVIseiCNKSTLPADFEEVLRCYTHNGYRVIACAGKTLpkrtwlys-qkvsreeVESNLEFLGFIIFQNKLKK 1033 Saccharomyces...

Feature 1                                                                                         
Q9H7F0        729 ETPAVLEDLHKANIRTVMVTGDSMLTAVSVARDCGMILPQDKVIIAEAl------------------------------- 777  human
Q27533        700 VTLGVINQLNRANIRTVMVTGDNLLTGLSVARECGIIRPSKRAFLVEHvpgeldeygrtki------------------- 760  nematode
CAD70973      896 ATAPVLKELAESNIGSVMVTGDNILTAISVARECSLINKTAHCFVGRFva------------------------------ 945  Neurospora cr...
NP_001096849  880 DTTKVINALNAAKIRTIMITGDNILTAISVARDCGIVSPSQSVITVHAdpigdsaniqtntgtecnfdnssdkhyk---- 955  fruit fly
NP_001023542  704 VTTEVIQKLNEANIRSVMVTGDNLLTALSVARECGIIVPNKSAYLIEHengvvdrrgrtvlt------------------ 765  nematode
EAL21261     1146 GTAPNIHTLRAAHLACRMVTGDNVRTAISVARECGLVSHSASVYIPTFip------------------------------ 1195 Cryptococcus ...
NP_001024768  733 VTLSVINELSVANIRCVMVTGDNLLTAMSVARECGIIRPTKKAFLITHs------------------------------- 781  nematode
Q04956       1024 NAPDIIHNLQTSGCQCIMSTGDNVLTSIHVAKKCGIINSNVESIIIGDvipvvgknnkqkkklvwynhkndtylkghdkt 1103 malaria paras...
O74431        857 TTATVIRELNDARIRTVMCTGDNVLTSICVGKRCGMLPEDGYVFLPRFde------------------------------ 906  Schizosacchar...
Q12697       1034 ETSETLKSLQDANIRTIMCTGDNILTAISVGREAGLIQCSRVYVPSINd------------------------------- 1082 Saccharomyces...

Feature 1                                                                                         
Q9H7F0            --------------------------------------------------------------------------------      human
Q27533            --------------------------------------------------------------------------------      nematode
CAD70973          --------------------------------------------------------------------------------      Neurospora cr...
NP_001096849      --------------------------------------------------------------------------------      fruit fly
NP_001023542      --------------------------------------------------------------------------------      nematode
EAL21261          --------------------------------------------------------------------------------      Cryptococcus ...
NP_001024768      --------------------------------------------------------------------------------      nematode
Q04956       1104 cidneftsiqsqmnsdnicgdnicgdniygdnicgdniygdningdningdniygdningdningdnintydniygdnyn 1183 malaria paras...
O74431            --------------------------------------------------------------------------------      Schizosacchar...
Q12697            --------------------------------------------------------------------------------      Saccharomyces...

Feature 1                                                                                         
Q9H7F0            --------------------------------------------------------------------------------      human
Q27533            --------------------------------------------------------------------------------      nematode
CAD70973          --------------------------------------------------------------------------------      Neurospora cr...
NP_001096849      --------------------------------------------------------------------------------      fruit fly
NP_001023542      --------------------------------------------------------------------------------      nematode
EAL21261          --------------------------------------------------------------------------------      Cryptococcus ...
NP_001024768      --------------------------------------------------------------------------------      nematode
Q04956       1184 ldycpteyhkctynnsilyrnnflykkenkkdknyknistlyehrtndiqfdklcdilinkdprnvnivltgkafiflkk 1263 malaria paras...
O74431            --------------------------------------------------------------------------------      Schizosacchar...
Q12697            --------------------------------------------------------------------------------      Saccharomyces...

Feature 1                                                                                         
Q9H7F0            --------------------------------------------------------------------------------      human
Q27533            --------------------------------------------------------------------------------      nematode
CAD70973          --------------------------------------------------------------------------------      Neurospora cr...
NP_001096849      --------------------------------------------------------------------------------      fruit fly
NP_001023542      --------------------------------------------------------------------------------      nematode
EAL21261          --------------------------------------------------------------------------------      Cryptococcus ...
NP_001024768      --------------------------------------------------------------------------------      nematode
Q04956       1264 kfysfhlpyyeecknivhyimkkkhkkikniinnhnsnlyyhyniidtfvkrmnkeymcfnkllykiqqkllynlihnly 1343 malaria paras...
O74431            --------------------------------------------------------------------------------      Schizosacchar...
Q12697            --------------------------------------------------------------------------------      Saccharomyces...

Feature 1                                                                                         
Q9H7F0            --------------------------------------------------------------------------------      human
Q27533            --------------------------------------------------------------------------------      nematode
CAD70973          --------------------------------------------------------------------------------      Neurospora cr...
NP_001096849      --------------------------------------------------------------------------------      fruit fly
NP_001023542      --------------------------------------------------------------------------------      nematode
EAL21261          --------------------------------------------------------------------------------      Cryptococcus ...
NP_001024768      --------------------------------------------------------------------------------      nematode
Q04956       1344 kkkkymnnyydidevhlignnnnnnnknnskekklplknkmkhirknesndnitfntytsnnihlskykyvhhknyyypd 1423 malaria paras...
O74431            --------------------------------------------------------------------------------      Schizosacchar...
Q12697            --------------------------------------------------------------------------------      Saccharomyces...

Feature 1                                                                                         
Q9H7F0            --------------------------------------------------------------------------------      human
Q27533            --------------------------------------------------------------------------------      nematode
CAD70973          --------------------------------------------------------------------------------      Neurospora cr...
NP_001096849      --------------------------------------------------------------------------------      fruit fly
NP_001023542      --------------------------------------------------------------------------------      nematode
EAL21261          --------------------------------------------------------------------------------      Cryptococcus ...
NP_001024768      --------------------------------------------------------------------------------      nematode
Q04956       1424 sctnlrkkknslfynlkkyiyyekkkylqhcllkhdnykkvelprikdinysyqmesiktrnfihslseqfafsnlilsf 1503 malaria paras...
O74431            --------------------------------------------------------------------------------      Schizosacchar...
Q12697            --------------------------------------------------------------------------------      Saccharomyces...

Feature 1                                                                                         
Q9H7F0            --------------------------------------------------------------------------------      human
Q27533            --------------------------------------------------------------------------------      nematode
CAD70973          --------------------------------------------------------------------------------      Neurospora cr...
NP_001096849      --------------------------------------------------------------------------------      fruit fly
NP_001023542      --------------------------------------------------------------------------------      nematode
EAL21261          --------------------------------------------------------------------------------      Cryptococcus ...
NP_001024768      --------------------------------------------------------------------------------      nematode
Q04956       1504 yiiknddnnvynknyiynknyiynknsicnknyicnknyiynknniynknniynkknilthaksvllsgsskkflkffsn 1583 malaria paras...
O74431            --------------------------------------------------------------------------------      Schizosacchar...
Q12697            --------------------------------------------------------------------------------      Saccharomyces...

Feature 1                                                                                         
Q9H7F0        778 -----------------------------------------------------------------pPKDGKVAKINWHya 792  human
Q27533        761 ------------------------------------------------------fvkqsvsssdevIEDDASVSISMCss 786  nematode
CAD70973      946 -----------------------------------------------------------------gHSRDPNAKLQWEsi 960  Neurospora cr...
NP_001096849  956 --------------------------------------lhytldlgsktsraylfkscfnsnlfdpETPEFTAQVGKTif 997  fruit fly
NP_001023542  766 ----------------------------------------------------irekedhhterqpkIVDLTKMTNKDCqf 793  nematode
EAL21261     1196 -----------------------------------------------------------------gTGVHDEARLDWSsv 1210 Cryptococcus ...
NP_001024768  782 -----------------------------------------------------------------kTEKDPLGRTKLFik 796  nematode
Q04956       1584 iirrhklkekknkknikrykmnhvnntskghiilnmcthgfkkdysslknkyrivnnkrymlkndnVYDRHMYNLTDMyr 1663 malaria paras...
O74431        907 -----------------------------------------------------------------eSESADEASRQLVwq 921  Schizosacchar...
Q12697       1083 -----------------------------------------------------------------tPLHGEPVIVWRDvn 1097 Saccharomyces...

Feature 1                                                                                         
Q9H7F0        793 dsltqcshpsaidpeaipvklvhdsle------------------------dlqmtryhfamngksfsvilehfqdlvpk 848  human
Q27533        787 twkgssegdgfsptntevetpnpvtadsl---------------------ghliassyhlaisgptfavivheypelvdq 845  nematode
CAD70973      961 dnpiyqlddrtllplppppegdvslpyd----------------------isnlrnyslavsgdvfrwvidyappevmrr 1018 Neurospora cr...
NP_001096849  998 hmestnslvnestssyaesglptsdslasvktidtwthndaelgikhtpdeswrrqecifamdgktwqivkdyfpeemei 1077 fruit fly
NP_001023542  794 aisgstfsv------------------------------------------------------------vtheypdlldq 813  nematode
EAL21261     1211 dddrlkldewtlkpltnqvgvamdtae------------------------aemhdyqlaltgdvfrwmleyaefetmer 1266 Cryptococcus ...
NP_001024768  797 esvsssendidtdsevrafdrkavl----------------------------rtatyqmaiagptysvitheypelvdr 848  nematode
Q04956       1664 gtqygcskkknkniymnnnnnilknkinr--------------------flehllvdkckrnichkytdikniklsiyey 1723 malaria paras...
O74431        922 aienneifldphtlrpnvdfadhepvsie---------------------larlkdfhialtgdvfrwlvdyaplnvfhh 980  Schizosacchar...
Q12697       1098 epdkildtktlkpvklgnnsveslrec-------------------------nytlavsgdvfrllfrdeneipeeylne 1152 Saccharomyces...

Feature 1                                                                                         
Q9H7F0        849 LMLHGTVFARMAPDQKTQLIEALQNVD--YFVGMCGDGANDCGALKRAHGGISLSe-lEASVASPFTSKTPSISCVPNLI 925  human
Q27533        846 LCSVCDVFARMAPDQKQSLVEQLQQID--YTVAMCGDGANDCAALKAAHAGISLSd-aEASIAAPFTSKVPDIRCVPTVI 922  nematode
CAD70973     1019 MLVTGKVFARMSPDEKHELVEKLQSID--YCCGFCGDGANDCGALKAADVGISLSe-aEASVAAPFTSRVFDIRCVPEVI 1095 Neurospora cr...
NP_001096849 1078 LLTRGSIYARMSPDQKQALVIELQNLD--YCVAMCGDGANDCGALKVAHAGISLSe-tEASIASPFTSRNPTISAVLKVI 1154 fruit fly
NP_001023542  814 LVLVCNVFARMAPEQKQLLVEHLQDVG--QTVAMCGDGANDCAALKAAHAGISLSe-aEASIAAPFTSKVADIRCVITLI 890  nematode
EAL21261     1267 MLVKGVIFARMSPDEKAELVERLQSLG--YTVAFCGDGANDCGALKAADVGVSLSe-aEASVAAPFTSQIPDISCMVEII 1343 Cryptococcus ...
NP_001024768  849 ITAMCDVYARMAPDQKAQLIGALQEIG--AKVSMCGDGANDCAALKAAHAGISLSq-aEASIAAPFTSNVPDIRCVPTVI 925  nematode
Q04956       1724 ILRTCTVYARMKPKDKSDLILSLKKLPnnSYVGMCGDGANDCLALSCADIGISLCnnnESSICSSFTSNKLCLHSIVHIL 1803 malaria paras...
O74431        981 ILLKAQIFARMSPSEKNELVSCFQNLN--YCVGFCGDGANDCGALKAADVGISLSe-aEASVAAPFTSKWFEITCVLDVI 1057 Schizosacchar...
Q12697       1153 ILLNSSIYARMSPDEKHELMIQLQKLD--YTVGFCGDGANDCGALKAADVGISLSe-aEASVAAPFTSKIFNISCVLDVI 1229 Saccharomyces...

Feature 1                                                                                         
Q9H7F0        926 REGRAALITSFCVFKFMALYSIIQYFSVTLLYSIlsnLGDFQFLFIDLAIILVVVFTMSLNPAWKELVAQRPP-SGLISG 1004 human
Q27533        923 SEGRAALVTSFGIFKYMAGYSLTQFVTVMHLYWIsniLTDGQFMYIDMFLITMFALLFGNTPAFYRLAHTPPP-TRLLSI 1001 nematode
CAD70973     1096 REGRAALVTSFSCFKYMSLYSAIQFTSVSFLYASasnLGDFQFLFIDLALILPIAVFMSWAGPFPELCRKRPT-ADLVSR 1174 Neurospora cr...
NP_001096849 1155 KEGRAALVTSFGIFKYMAAYSLVQFISVMILYSIdsnLTDKQYLYVDLGLISIFAFFFGKTESFDGMLVEQVPlSSLISS 1234 fruit fly
NP_001023542  891 SEGRAALVTSYSAFLCMAGYSLTQFISILLLYWIatsYSQMQFLFIDIAIVTNLAFLSSKTRAHKELASTPPP-TSILST 969  nematode
EAL21261     1344 KEGRAALVTSFSCFKYMALYSMIQFMTVTLLYSFassLGDFQFLYIDLFIIIPIAVTMGRTLPYPKIHPKRPT-ASLVSR 1422 Cryptococcus ...
NP_001024768  926 KEGRCALVTSYAVSKYMAAYSLNEFLSVMLLYNDgtnISDGQFLYIDLVLITLVALFLGNTEASRKLSGIPPP-RRLATS 1004 nematode
Q04956       1804 IEGRASLVNSFQLFKFISLYSIMQCSQVLILYSIsnkLTDNQYIFIDIVTILPLSIFMCWTSASEKLSKNIPI-GKLFSF 1882 malaria paras...
O74431       1058 KDGRAALVTSFSCFQYMALYSAIQFITVSILYTTnsnLGDFQFLFIDLVIILPIAVFMGRSRPYHRLAHKRPT-ANLVSK 1136 Schizosacchar...
Q12697       1230 REGRAALVTSFACFQYMSLYSAIQFITITILYSRgsnLGDFQFLYIDLLLIVPIAICMSWSKSYEKIDKKRPS-ANLVSP 1308 Saccharomyces...

Feature 1                                                        
Q9H7F0       1005 ALLFSVLSQIIICIGFQSLgffwVKQQPWYEVWHPKSDACNTTGSGF 1051 human
Q27533       1002 ASMTSVVGQLIIIGVVQFIvffsTSQQPWFTPYQPPVDDEVEDKRSM 1048 nematode
CAD70973     1175 KVLVPLLGQMFICIFIQTMafiaVREQPWFIPPKVEHEKVNIRNSEN 1221 Neurospora crassa
NP_001096849 1235 TPLASLLLHLTVVTAFQVTcwvhLHQQPWFKAFEPADEDHLGCFENY 1281 fruit fly
NP_001023542  970 ASMVSLFGQLAIGGMAQVAvfclITMQSWFIPFMPTHHDNDEDRKSL 1016 nematode
EAL21261     1423 KVLISIIGQILINAAIQVFvfvwVRKQPWYTKPDTDVDKLETFNFEN 1469 Cryptococcus neoformans var. neoformans B-3501A
NP_001024768 1005 AFYFSVFGQMFFNIITQTTgyllVRGQSWYVPNPEELDNTTTMIGTT 1051 nematode
Q04956       1883 PILISIYGQIIIQLFFVMIslvvLMNLSFYKYDKNKVMKEKSDDTYL 1929 malaria parasite P. falciparum
O74431       1137 RILSPLIGQIVLICIIQYItlriVRREPWYIPPPANSSDTNITNSDV 1183 Schizosaccharomyces pombe 972h-
Q12697       1309 KILVPLLISVFLVFLFQFIpwiiVQKMSWYIKPIVGGDDAVQSSDNT 1355 Saccharomyces cerevisiae S288c

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