GEO DataSets for BioProject (Select 132903) - GEO DataSets

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Items: 2

Select item 2000243421.

Athsq1 is linked to Cdkn2a

(Submitter supplied) Common genetic variants in a 58-kilobase (kb) region of chromosome 9p21, near the CDKN2A/B cell proliferation inhibitor genes, are strongly associated with coronary artery disease (CAD). We previously reported a congenic mouse model harboring an atherosclerosis susceptibility locus in a region of homology with the human 9p21 locus. We now report markedly decreased Cdkn2a (cyclin-dependent kinase inhibitor 2a) mRNA expression in macrophages and increased circulating levels of Ly6Chigh inflammatory monocytes in congenic mice compared to controls. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS4527
Platform:: GPL9734
40 Samples

Download data: CEL

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Accession:: GSE24342

ID:: 200024342

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 45272.

Atherosclerosis susceptibility model: macrophages

Analysis of macrophages from C57BL/6.MOLFc4(51Mb)-Ldlr-/- mice. This model harbors an atherosclerosis susceptibility locus and the region homologous to the human 9p21 locus associated with coronary artery disease. Results provide insight into the molecular basis of increased atherosclerotic risk.