GEO DataSets

(Submitter supplied) Background: The etiology of Inflammatory Bowel Disease (IBD) is unclear but involves both genetics and environmental factors, including the gut microbiota. Indeed, exacerbated activation of the gastrointestinal immune system toward the gut microbiota occurs in genetically susceptible hosts and under the influence of the environment. For instance, a majority of IBD susceptibility loci lie within genes involved in immune responses, such as caspase recruitment domain member 9 (Card9). more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platforms:

GPL21163 GPL10787

21 Samples

Download data: TXT

(Submitter supplied) To screen changed gene expression, gene expression microarray analysis was performed in the cerebral cortex at the third postnatal week (P3W) of C57/B6J mice perinatally exposed to BPA (500 ug/kg body/day) .

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL10787

12 Samples

Download data: TXT

(Submitter supplied) This study aims to determine how gene expression in the lung of mice is affected by cigarette smoking during infection with an H7N9 influenza virus.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL10787

80 Samples

Download data: TXT

(Submitter supplied) We identified Litchi (Gm2990) as a novel regulator for orchestrating motor neuron (MN) maturation. To study the function of Lithci during MN differentiation, we knocked out Litchi in mouse ESCs and differentiated into MN.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL10787

8 Samples

Download data: TXT

(Submitter supplied) To investigate the claudin-7 function in vivo, we generated a claudin-7 knockout mouse model by gene targeting through homologous recombination. In this study, we report that Cln7-/- pups show Na+, Cl-, and K+ wasting and chronic dehydration phenotypes. The dramatic increase of aldosterone synthase mRNA level suggests that these mice suffer from mishandling of NaCl and fluid in the distal nephrons. Deletion of claudin-7 invokes several compensatory changes, such as increased renin, serum-glucocorticoid-induced kinase 1 (SGK1), epithelial Na+ channel (ENaCα), Na+-Cl- cotransporter (NCC), as well as aquaporin (AQP) 2 mRNA levels, demonstrating the cross talks between paracellular and transcellular ion transport pathways.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL10787

8 Samples

Download data: TXT

(Submitter supplied) Histone acetylation, which is regulated by histone acetyltransferases (HATs) and histone deacetylases (HDACs), plays a crucial role in the control of gene expression. HDAC inhibitors (HDACi) have shown potential in cancer therapy; however, the specific roles of HDACs in early embryos remain unclear. Moreover, although some pan-HDACi have been used to maintain cellular undifferentiated states in early embryos, the specific mechanisms underlying their effects remain unknown. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL10787

39 Samples

Download data: TXT

(Submitter supplied) Skin cancer is the most prevalent cancer in humans, especially in the United States, Australia, and New Zealand. Australia and New Zealand are the two countries with the highest rates of skin cancer in the world, about four times higher than the United States, the United Kingdom and Canada. According to statistics, one American dies of skin cancer every hour. Studies have shown that ultraviolet radiation is the main cause of skin cancer, and ultraviolet rays are mainly divided into UVA, UVB and UVC according to wavelength, UVA and UVB can cause DNA damage, and UVB is the main factor that induces skin cancer. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL10787

6 Samples

Download data: TXT

(Submitter supplied) Background & Aims: Combined HCC-iCCA is a rare liver tumor type and is often not well separated from HCC and iCCA. In this study, we analyzed major differences between combined HCC-iCCA and iCCA. Methods: We first characterized major differences between combined HCC-iCCA and iCCA by GSEA analysis. Consequently, we used CCl4 to induce chronic liver disease and subsequent liver carcinoma formation in mice. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL10787

32 Samples

Download data: TXT

(Submitter supplied) In hepatic dysfunction, renal pharmacokinetic adaptation can be observed, although information on the changes in drug exposure and the interorgan regulation of membrane transporters in kidney in liver diseases is limited. This study aimed to clarify the effects of renal exposure to nephrotoxic drugs during cholestasis induced by bile duct ligation (BDL). Among the 11 nephrotoxic drugs examined, the tissue accumulation of imatinib and cisplatin in kidney slices obtained from mice 2 weeks after BDL operation was higher than that in sham-operated mice. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL10787

4 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL10787

24 Samples

Download data: TXT

(Submitter supplied) The aim of this study was to determine the impact of early life stress on the motivation for a palatable nutritional reward in two mouse strains. Our data showed that MS associated with unpredictable chronic mild stress in lactating dams exacerbated motivation for a palatable food reward (sweetened milk) in both males and females C3H/HeN mice. Interestingly, no effect of MS was reported on motivation in C57Bl/6J mice strain. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL10787

8 Samples

Download data: TXT

(Submitter supplied) The aim of this study was to determine the impact of early life stress on the motivation for a palatable nutritional reward in two mouse strains. Our data showed that MS associated with unpredictable chronic mild stress in lactating dams exacerbated motivation for a palatable food reward (sweetened milk) in both males and females C3H/HeN mice. Interestingly, no effect of MS was reported on motivation in C57Bl/6J mice strain. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL10787

8 Samples

Download data: TXT

(Submitter supplied) The aim of this study was to determine the impact of early life stress on the motivation for a palatable nutritional reward in two mouse strains. Our data showed that MS associated with unpredictable chronic mild stress in lactating dams exacerbated motivation for a palatable food reward (sweetened milk) in both males and females C3H/HeN mice. Interestingly, no effect of MS was reported on motivation in C57Bl/6J mice strain. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL10787

8 Samples

Download data: TXT

(Submitter supplied) To examine gene expression in pancreatic islet in vivo exposed to E2, we have employed whole genome microarray hene expression profiling.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL10787

4 Samples

Download data: TXT

(Submitter supplied) To investigate gene expression patterns in mouse hepatocytes induced by ionizing radiation and calorie restriction.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL10787

42 Samples

Download data: TXT

(Submitter supplied) Background & Aims: Combined HCC/iCCA is a rare liver tumor type. We generated a transgenic mouse model (AlfpCre+-Trp53fl/fl/Alb-HBs+ tg mouse) which developed next to HCC combined HCC/iCCA (cHCC/iCCA). We compared bilineal differentiated liver carcinoma cell lines generated from primary liver tumors of AlfpCre+-Trp53fl/fl/Alb-HBs+ tg mice and transplanted them into C57BL/6J mice to monitor there agressiveness. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL10787

12 Samples

Download data: TXT

(Submitter supplied) Cholesterol 7alpha-hydroxylase (CYP7A1) is the rate limiting enzyme of bile acid biosynthetic pathway to convert cholesterol to bile acids, which is a major output pathway for cholesterol catabolism. In this study, we aimed to assess the potential regulatory mechanisms of microRNA-185 (miR-185) involved in cholesterol and bile acid homeostasis. This study provides convincing evidences about the critical role of miR-185 in FoxO1 modulation at both posttranscriptional and posttranslational levels, which account for the effects on CYP7A1 gene and its mediated cholesterol-bile acid metabolism. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL10787

16 Samples

Download data: TXT

(Submitter supplied) The survival motor neuron 1 (SMN1) gene is the causative gene for the spinal muscular atrophy (SMA) disease, the first genetic cause of infant mortality. It affects primarily motor neurons which are the targets of the approved genetic therapies aimed to compensate for the loss of SMN1. However, the limitations of these therapies are now evident since they are not cures, and alternative strategies need to be investigated. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL10787

27 Samples

Download data: TXT

(Submitter supplied) A saponin monomer Tubeimoside I (TA) was found to have potential adjuvant activity. Since the adaptive immune response is mediated by innate immunity, we took the immune injection site (quadriceps femoris muscle) as the local immune microenvironment, and injected TA (50 μg) into quadriceps muscle to prepare samples. Muscles injected with PBS were served as the negative control. RNA was extracted 4 hours after drug treatment, and samples were prepared for whole-gene transcriptome expression profile microarray detection.

Organism:

Mus musculus

Type:

Expression profiling by array; Non-coding RNA profiling by array

Platform:

GPL10787

6 Samples

Download data: TXT

(Submitter supplied) To study the role of the c-fms tyrosine kinase receptor expression in prostate cancer cells, we generated a cell line model from the C2H mouse prostate cancer cell line overexpressing the c-fms receptor (N18-CFMS clone) and treated it or not with the c-fms ligand CSF1.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL10787

6 Samples

Download data: TXT