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Items: 1 to 20 of 137

1.

Experience modulates the effects of histone deacetylase inhibitors on gene and protein expression in the hippocampus: Impaired plasticity in aging

(Submitter supplied) The therapeutic potential of histone deacetylase inhibitor (HDACi) treatment has attracted considerable attention in the emerging area of cognitive neuroepigenetics. The possibility that ongoing cognitive experience importantly regulates the cell biological effects of HDACi administration, however, has not been systematically examined. In an initial experiment addressing this issue, we tested whether water maze training influences the gene expression response to acute systemic HDACi administration in the young adult rat hippocampus. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL6101
84 Samples
Download data: TXT
Series
Accession:
GSE172109
ID:
200172109
2.

Hippocampal Gene Expression in bred High Responder (bHR) vs. bred Low Responder (bLR) Rats

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Rattus norvegicus
Type:
Expression profiling by high throughput sequencing; Expression profiling by array
Platforms:
GPL6101 GPL27768 GPL14844
72 Samples
Download data: CEL, IDAT
Series
Accession:
GSE140599
ID:
200140599
3.

Hippocampal Gene Expression in bred High Responder (bHR) vs. bred Low Responder (bLR) Rats: Illumina Microarray Data from Generation F15

(Submitter supplied) The strong pattern of comorbidity amongst psychiatric disorders is believed to be generated by a spectrum of latent liability, arising from a complex interplay of genetic risk and environmental factors, such as stress and childhood adversity. At one end of this spectrum are internalizing disorders, which are associated with neuroticism, anxiety, and depression. At the other end of the spectrum are externalizing disorders, which are associated with risk-taking and novelty-seeking, as seen in mania, substance abuse, and impulse-control disorders. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL6101
12 Samples
Download data: IDAT, TXT
Series
Accession:
GSE140594
ID:
200140594
4.

Microarray Analysis of Striatal Tissue derived RNA isolated from Chronic Levodopa (L-DOPA) treated Parkinsonian and Dyskinetic (LID) Rats as compared to Parkinsonian Disease (PD) Control Rats

(Submitter supplied) We compared differential gene expression between Striatal tissue derived RNA isolated from Chronic Levodopa (L-DOPA) treated (L-Dopa methyl ester plus benserazide were given at 25 mg/kg and 6.25 mg/kg dose) - Parkinsonian and Dyskinetic Rats (LID Rats) for 8 days as compared to Parkinsonian Disease Control Rats (PD Control Rats). The hypothesis tested in the present study was that whether Inflammation has any role in Chronic Levodopa Induced Dyskinesia in Rats of Parkinson's disease model- as compared to Control Rats with Prakinson's disease by performing differential gene expression and pathway analyses.
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL6101
12 Samples
Download data: IDAT
Series
Accession:
GSE139438
ID:
200139438
5.

Gene expression profile of liver tissue in low-dose, repeated diethylnitrosamine (DEN)-treated rat treated with epigallocatechin gallate (EGCG)

(Submitter supplied) Background: Hepatocellular carcinoma (HCC) is increasing in incidence and treatment is often unsuccessful. Thus, prevention in high-risk patients with established cirrhosis has been proposed as an alternative strategy. It has been suggested that the increased inflammation and fibrogenesis observed during cirrhosis predisposes the liver to future malignant transformation to HCC through a “field effect”. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL6101
6 Samples
Download data: TXT
Series
Accession:
GSE67880
ID:
200067880
6.

Thyroid hormone inhibits hepatocellular carcinoma progression via induction of differentiation and metabolic reprogramming

(Submitter supplied) T3 induces a global shift of the expression profile of KRT-19+ lesions towards that of fully differentiated hepatocytes
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL6101
48 Samples
Download data: TXT
Series
Accession:
GSE131034
ID:
200131034
7.

Lipoic acid induced endoplasmic reticulum stress-mediated apoptosis in rat hepatoma cells:identification of new ER stress aggravator (ERSA)

(Submitter supplied) Study gene expression during apoptotic process α Lipoic acid-induced.
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL6101
12 Samples
Download data: TXT
Series
Accession:
GSE59164
ID:
200059164
8.

Genome-wide analysis of liver gene expression in prenatally undernourished male rat offspring under high-fat diet

(Submitter supplied) Based on the developmental origin of health of disease hypothesis, we previously showed that prenatal 70% maternal food restriction (FR30) predisposes the offspring to development of pathologies in adulthood. In the present study, we focused on the liver gene expression profile of standard and high fat (HF)-fed FR30 adult offspring.
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL6101
4 Samples
Download data: TXT, XLSX
Series
Accession:
GSE134149
ID:
200134149
9.

Comparative analysis of gene expression profile of pre-defined niches within demyelinated white matter in rats

(Submitter supplied) Microenviromental niche characterization by comparative transcriptome profiling. The hypothesis tested in the present study was that unique properties of the perivascular niche within remyelinating white matter would create microenvironment that favor the alternative differentiation of oligodendrocyte precursor cells.
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL6101
24 Samples
Download data: TXT
Series
Accession:
GSE93645
ID:
200093645
10.

The gene expression profile of rat hepatocytes grown on decelllularized liver

(Submitter supplied) The objective of this study was to determine the gene expression profile of rat hepatocytes grown on decellularized rat liver matrices as a function of time.
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL6101
24 Samples
Download data: IDAT, TXT
Series
Accession:
GSE107274
ID:
200107274
11.

Conserved and species-specific molecular denominators in mammalian skeletal muscle aging

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus; Macaca mulatta; Homo sapiens; Rattus norvegicus
Type:
Expression profiling by array
Platforms:
GPL6885 GPL6101 GPL10558
64 Samples
Download data
Series
Accession:
GSE87109
ID:
200087109
12.

Conserved and species specific molecular denominators in mammalian aging [rat]

(Submitter supplied) Aging is a complex phenomenon involving functional decline in multiple physiological systems. We focused on skeletal muscle to identify pathways that modulate function and healthspan by global expression profiles and specific mechanisms fundamental to aging processes. Our experimental design integrated comparative analysis of mice, rats, rhesus monkeys and humans and targeted three key time points during their lifespans. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL6101
15 Samples
Download data: TXT
Series
Accession:
GSE87107
ID:
200087107
13.

Integrated metabolic models for xenobiotic induced mitochondrial toxicity in skeletal muscle

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL6101
16 Samples
Download data
Series
Accession:
GSE101847
ID:
200101847
14.

Integrated metabolic models for xenobiotic induced mitochondrial toxicity in skeletal muscle (compound 197 experiments)

(Submitter supplied) There is a need for robust in vitro models to sensitively capture skeletal muscle adverse toxicities early in the research and development of novel xenobiotics. To this end, an in vitro rat skeletal muscle model (L6) was used to study the translation of transcriptomics data generated from an in vivo rat model. Novel sulfonyl isoxazoline herbicides were associated with skeletal muscle toxicity in an in vivo rat model. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL6101
8 Samples
Download data: TXT
Series
Accession:
GSE101845
ID:
200101845
15.

Integrated metabolic models for xenobiotic induced mitochondrial toxicity in skeletal muscle (compound 177 experiments)

(Submitter supplied) There is a need for robust in vitro models to sensitively capture skeletal muscle adverse toxicities early in the research and development of novel xenobiotics. To this end, an in vitro rat skeletal muscle model (L6) was used to study the translation of transcriptomics data generated from an in vivo rat model. Novel sulfonyl isoxazoline herbicides were associated with skeletal muscle toxicity in an in vivo rat model. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL6101
8 Samples
Download data: TXT
Series
Accession:
GSE101844
ID:
200101844
16.

Molecular mechanisms of pulmonary response progression in crystalline silica exposed rats

(Submitter supplied) The capability to detect target organ toxicity as well as to determine the molecular mechanisms underlying such toxicity by employing surrogate biospecimens that can be obtained by a non-invasive or minimally invasive procedure has significant advantage in occupational toxicology. Pulmonary toxicity and global gene expression profile in the lungs, peripheral blood and bronchoalveolar lavage (BAL) cells were determined in rats at 44-weeks following pulmonary exposure to crystalline silica (15 mg/m3, 6-hours/day, 5 days). more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL6101
36 Samples
Download data: TXT
Series
Accession:
GSE41572
ID:
200041572
17.

Using DNA microarray to screen intracellular signal pathways of hypoglycemic activity by electroacupuncture of Zusanli (ST36) acupoints in streptozotocin-induced rats with diabetes

(Submitter supplied) The aim of this study is to screen the possible effective intracellular signaling pathways of EA on bilateral Zusanli acupoint (ST36) by DNA microarray in rats with diabetes. Streptozotocin (STZ) rats with diabetes were randomly assigned to the experimental (EA) group or the control (non-EA) group. The exploratory methods for analysis in this study were the following points: (i) detecting plasma glucose levels (ii) pathway analysis by DNA microarray in rats' gastrocnemius muscle. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL6101
2 Samples
Download data: TXT
Series
Accession:
GSE55573
ID:
200055573
18.

Genome-wide RNA expression analysis of rat dorsal root ganglion tissue after local absorbable collagen sponge implantation and BMP-2 exposure

(Submitter supplied) Analysis of whole dorsal root ganglion tissue expression signatures in responses to absorbable collagen sponge implantation with and without BMP-2 exposure. The hypothesis is that inflammatory macrophage-associated responses to ACS implantation contributes to nociception in the DRG and spinal nerve.
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL6101
33 Samples
Download data: TXT
Series
Accession:
GSE77384
ID:
200077384
19.

Molecular liver cancer prevention in cirrhosis by organ transcriptome analysis and lysophosphatidic acid pathway inhibition

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens; Mus musculus; Rattus norvegicus
Type:
Expression profiling by array; Expression profiling by high throughput sequencing
4 related Platforms
298 Samples
Download data
Series
Accession:
GSE64520
ID:
200064520
20.

Gene expression profiles of fractionated cells from cirrhotic rat livers

(Submitter supplied) Gene expression profiling was performed in each of hepatocyte fraction and non-parenchymal cell fraction enriched with activated hepatic stellate cells/myofibroblasts from cirrhotic rat livers induced by repeated, low-dose diethylnitrosamine (DEN) treatment.
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL6101
12 Samples
Download data: TXT
Series
Accession:
GSE63726
ID:
200063726
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