GEO DataSets

(Submitter supplied) Bioassay-guided fractionation of a cytotoxic extract derived from the Australian endemic plant Hernandia albiflora (twigs) resulted in the isolation of the two known compounds: deoxypodophyllotoxin and thalicthuberine. Both compounds were tested for their inhibition of LNCaP cell viability. Thalicthuberine (TH, IC50=2.0 µM) was selected for mechanism of action studies. Ongoing investigations have shown that TH induced a strong accumulation of LNCaP cells in mitosis, severe mitotic spindle defects and asymmetric cell divisions, ultimately leading to mitotic catastrophe accompanied by cell death through apoptosis. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL16604

9 Samples

Download data: TXT

(Submitter supplied) The lack of a cure for metastatic prostate cancer (PCa) highlights the urgent need for more efficient drugs to fight this disease. Here, we report the molecular mechanism of action of the natural product 6-acetoxy-anopterine (6-AA) in malignant cells of the prostate. This potent cytotoxic alkaloid from the endemic Australian tree Anopterus macleayanus induced at low nanomolar doses a strong accumulation of LNCaP and PC3 PCa cells in mitosis, severe mitotic spindle defects and asymmetric cell divisions, ultimately leading to mitotic catastrophe accompanied by cell death through apoptosis. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL16604

10 Samples

Download data: TXT

(Submitter supplied) annotation from RefSeq and EntrezGene Database (downloaded: April, 2012) Protocol: SurePrint G3 4x180K format, feature and microarray designed using eArray

Organism:

Homo sapiens

10 Series

1 Related Platform

185 Samples

Download data: TXT