GSM471650[Accession] - GEO DataSets

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Items: 4

Select item 2000190591.

PTEN heterozygosity promotes tumorigenesis in a Smoothened active mouse model of medulloblastoma

(Submitter supplied) Recent publications have described an important role for cross talk between PI-3 kinase and sonic hedgehog signaling pathways in the pathogenesis of medulloblastoma. Our primary objective was to determine if loss of Pten promotes medulloblastoma tumor formation. When mice expressing SmoA1 were crossed with mice heterozygous for Pten, SmoA1 +; Pten +/- mice exhibited decreased survival, an increased incidence, and a shorter time to onset of symptoms, compared to SmoA1 +; Pten +/+ mice. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS3582
Platform:: GPL6887
12 Samples

Download data: TXT

Series

Accession:: GSE19059

ID:: 200019059

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 35822.

PTEN heterozygosity effect on Smoothened-active mouse model

Analysis of medulloblastoma (MB) tumors from mice heterozygous for PTEN. SmoA1 +; Pten +/- mice exhibited decreased survival, an increased incidence, and a shorter time to onset of symptoms, compared to SmoA1 +; Pten +/+ mice. Results provide insight into the role of PTEN in the pathogenesis of MB.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 2 genotype/variation sets

Platform:: GPL6887
Series:: GSE19059
12 Samples

Download data: TXT

DataSet

Accession:: GDS3582

ID:: 3582

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 1000068873.

Illumina MouseWG-6 v2.0 expression beadchip

(Submitter supplied) The MouseWG-6 v2.0 Expression BeadChip offer the most up-to-date content for whole-genome expression profiling in the mouse. Featuring content derived from the National Center for Biotechnology Information Reference Sequence (NCBI RefSeq) database (Build 36, Release 22). Please use the GEO Data Submission Report Plug-in v1.0 for Gene Expression which may be downloaded from https://icom.illumina.com/icom/software.ilmn?id=234 to format the normalized and raw data. more...