GSM5172492[Accession] - GEO DataSets

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Items: 4

Select item 2001689301.

Genome-wide DNA methylome analysis identifies putative biomarkers associated with the survival of human ovarian cancers

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Methylation profiling by genome tiling array

Platform:: GPL21145
110 Samples

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Series

Accession:: GSE168930

ID:: 200168930

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Select item 2001689262.

Genome-wide DNA methylome analysis identifies putative biomarkers associated with the survival of human ovarian cancers [80 cases]

(Submitter supplied) We conducted an epigenome-wide association study (EWAS) to evaluate global DNA methylation in EOC. In a retrospective cohort of 80 primary ovarian cancers, we observed that global DNA hypermethylation was significantly associated with high-grade tumors, platinum-resistance and poor prognosis. We determined that 8,600 differentially methylated probes (DMPs) were enriched in the intergenic regions of 4,673 genes involved in small GTPases and were significantly correlated with the PI3K-AKT, MAPK, RAS, and WNT oncogenic pathways.