Similar studies for GEO DataSets (Select 200053850) - GEO DataSets

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Items: 20

Select item 2000538501.

miRNA expression profiling of Human Myeloma Cell Lines Pre- and Post- 5'azacytidine Treatment

(Submitter supplied) We performed genome-wide miRNA expression profiling (MEP) of a panel of four human Myeloma cell lines treated with 5'azacytidine compared to control (DMSO treatment), with the objective of unmasking miRNAs silenced by DNA hypermethylation.

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by array

Platform:: GPL16770
8 Samples

Download data: TXT

Series

Accession:: GSE53850

ID:: 200053850

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000807502.

Gene expression profiling of the prostate cancer cell line PC3.

(Submitter supplied) To study the effect of miR-130a in prostate cancer, PC3 cells overexpressing miR-130a were analyzed for global gene expression.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL17586
6 Samples

Download data: CEL, CHP

Series

Accession:: GSE80750

ID:: 200080750

Select item 2000401863.

miRNA expression profiles in endometriotic cyst stromal cells (ECSCs).

(Submitter supplied) To identify the miRNAs which play a role in the development of endometriosis, we explored differentially expressed miRNAs between ECSCs (N=8) and normal endometrial stromal cells (NESCs, n=8) using miRNA microarray. The expression profiles in ECSCs and NESCs were obtained, then the miRNAs were filtered by signal intensity (20.0<, at least one out of 16 samples have values within range) and flags (at least 70% of cases have good flags). more...

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by array

Platform:: GPL14767
16 Samples

Download data: TXT, XLSX

Series

Accession:: GSE40186

ID:: 200040186

Select item 2000417604.

Gene expression signatures in a human bladder cancer cell line SW780 transfected with miR-137 precursor molecule

(Submitter supplied) To clarify the effect of miRNAs, we carried out a gene expression microarray analysis of SW780 cells transfected with a miR-137 precursor or a negative control. We found that 1,326 probe sets (1,016 unique genes) were downregulated (>2-fold) by ectopic miR-137 expression, including the previously reported miR-137 target genes CDK6, CDC42 and AURKA. Moreover, Gene Ontology analysis revealed that genes related to the cell cycle were significantly enriched among the affected genes.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL13607
2 Samples

Download data: TXT

Series

Accession:: GSE41760

ID:: 200041760

Select item 2000104555.

Genes regulated by miR-34b/c and DAC

(Submitter supplied) We found frequent epigenetic silencing of microRNA-34b/c in human colorectal cancer. Introduction of miR-34b/c into a colorectal cancer cell line induced significant changes in gene expression profile. We also found overlap between the genes downregulated by miR-34b/c and those downregulated by DAC. Keywords: dose response

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL4133
5 Samples

Download data: TXT

Series

Accession:: GSE10455

ID:: 200010455

Select item 2000687436.

Gene expression signatures in GIST-T1 cells transfected with miR-34a and miR-335 mimic molecules

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL16699
8 Samples

Download data: TXT

Series

Accession:: GSE68743

ID:: 200068743

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000687427.

Gene expression signatures in GIST-T1 cells transfected with a miR-335 mimic molecule

(Submitter supplied) To clarify the effect of miRNAs, we carried out a gene expression microarray analysis using GIST-T1 cells transfected with a miR-335 mimic or a negative control. We found that 1,095 probe sets (853 unique genes) were downregulated (>1.5-fold) by ectopic miR-335 expression.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL16699
4 Samples

Download data: TXT

Series

Accession:: GSE68742

ID:: 200068742

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000687408.

Gene expression signatures in GIST-T1 cells transfected with a miR-34a mimic molecule

(Submitter supplied) To clarify the effect of miRNAs, we carried out a gene expression microarray analysis using GIST-T1 cells transfected with a miR-34a mimic or a negative control. We found that 2,621 probe sets (1,933 unique genes) were downregulated (>1.5-fold) by ectopic miR-34a expression, including PDGFRA gene which was previously reported as a miR-34a target gene.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL16699
4 Samples

Download data: TXT

Series

Accession:: GSE68740

ID:: 200068740

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000062059.

Human myeloma cell lines gene expression profiling

(Submitter supplied) In order to investigate the patterns of genetic lesions in a panel of 23 Human Multiple Myeloma Cell Lines (HMCLs), we made a genomic integrative analysis involving FISH and both gene expression and genome-wide profiling approaches. The expression profiles of the genes targeted by the main IGH translocations showed that the WHSC1/MMSET gene involved in t(4;14)(p16;q32) was expressed at different levels in all of the HMCLs, and that the expression of the MAF gene was not restricted to the HMCLs carrying t(14;16)(q32;q23). more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL96
23 Samples

Download data: CEL

Series

Accession:: GSE6205

ID:: 200006205

Select item 20001426110.

Dexamethasone-resistant multiple myeloma cell line OPM1 treated with Dexamethasone and/or DAC

(Submitter supplied) To identify genes responsible for the synergistic effect of DAC with Dex, we performed cDNA microarray analyses using cDNA prepared from Dex-resistant OPM1 cells treated with/without Dex, DAC or DAC+Dex.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL4133
4 Samples

Download data: TXT

Series

Accession:: GSE14261

ID:: 200014261

Select item 20002842511.

Modulation of the osteosarcoma expression phenotype by miRNAs

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by array; Expression profiling by array

Platforms:: GPL8227 GPL13376
46 Samples

Download data: TXT

Series

Accession:: GSE28425

ID:: 200028425

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20002842412.

Modulation of the osteosarcoma expression phenotype by miRNAs [Illumina]

(Submitter supplied) Background: Osteosarcomas are the most common primary malignant tumors of bone and show multiple and complex genomic aberrations. miRNAs are non-coding RNAs capable of regulating gene expression at the post transcriptional level, and miRNAs and their target genes may represent novel therapeutic targets or biomarkers for osteosarcoma. In order to investigate the involvement of miRNAs in osteosarcoma development, global microarray analyses of a panel of 19 human osteosarcoma cell lines was performed. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL13376
23 Samples

Download data: TXT

Series

Accession:: GSE28424

ID:: 200028424

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20002842313.

Modulation of the osteosarcoma expression phenotype by miRNAs [Agilent]

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by array

Platform:: GPL8227
23 Samples

Download data: TXT

Series

Accession:: GSE28423

ID:: 200028423

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20008771614.

EZH2 inhibition in multiple myeloma downregulates myeloma associated oncogenes and upregulates microRNAs with potential tumor suppressor functions

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array; Non-coding RNA profiling by array

Platforms:: GPL20712 GPL17585
14 Samples

Download data: CEL, TXT

Series

Accession:: GSE87716

ID:: 200087716

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20008771515.

EZH2 inhibition in multiple myeloma downregulates myeloma associated oncogenes and upregulates microRNAs with potential tumor suppressor functions [miRNA expression]

(Submitter supplied) Multiple Myeloma (MM) is a plasma cell tumor localized to the bone marrow (BM). Despite current progress in improving patient outcome, MM remains largely incurable. Disease clonal and interpatient heterogeneity has hampered identification of a common underlying mechanism for disease establishment and have slowed the development of novel targeted therapies. Epigenetic aberrations are now emerging as increasingly important in tumorigenesis, thus selective targeting of crucial epigenetic enzymes may provide new therapeutic potential in cancer including MM. more...

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by array

Platform:: GPL20712
8 Samples

Download data: TXT

Series

Accession:: GSE87715

ID:: 200087715

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20008771416.

EZH2 inhibition in multiple myeloma downregulates myeloma associated oncogenes and upregulates microRNAs with potential tumor suppressor functions [mRNA expression]

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL17585
6 Samples

Download data: CEL

Series

Accession:: GSE87714

ID:: 200087714

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20003594817.

Restoration of miR-214 expression reduces cell growth of myeloma cells through a positive regulation of P53 and inhibition of DNA replication

(Submitter supplied) MicroRNAs have been demonstrated to be deregulated in multiple myeloma (MM). We have previously reported the downregulation of miR-214 in MM compared to normal plasma cells. In the present study, we have explored the functional role of miR-214 in myeloma pathogenesis. Ectopic expression of miR-214 reduced cell growth and induced apoptosis of myeloma cells. In order to identify the potential direct target genes of miR-214 which could be involved in the biological pathways regulated by this miRNA, gene expression profiling of H929 myeloma cell line transfected with precursor miR-214 was carried out. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6244
6 Samples

Download data: CEL

Series

Accession:: GSE35948

ID:: 200035948

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20001749818.

Identification of MicroRNA Expression Patterns and a MicroRNAs/mRNA Regulatory Network in Multiple Myeloma

(Submitter supplied) To date, little evidence of miRNA expression/deregulation in multiple myeloma (MM) has been reported. To characterize miRNA expression profiling of MM plasma cells (PCs) and integrate miRNA expression data with other molecular features of MM patients, global miRNA expression profiles were generated for PCs isolated from BM biopsies of 38 newly diagnosed MM, 2 plasma cell leukemia patients, and 3 healthy donors; the samples were also profiled for global gene expression, and nineteen of them underwent genome-wide DNA analysis using high-density SNP-microarrays. more...

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by array; Expression profiling by array; Genome variation profiling by SNP array

Platforms:: GPL8227 GPL2005 GPL9021
102 Samples

Download data: CEL, TXT

Series

Accession:: GSE17498

ID:: 200017498

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20005624319.

Differentially expressed genes after miRNA or siRNA transfection in human cancer cell lines

(Submitter supplied) To identify differentially expressed genes by anti cancer treatments (microRNAs or siRNAs) in human cancer, several cell lines (bladder cancer, prostate cancer, hypopharyngeal cancer and lung squamous cell carcinoma) were subjected to Agilent whole genome microarrays.