GEO DataSets

(Submitter supplied) The objective of this study was to understand the mechanisms behind the contribution of the alpha7BX2 integrin to improvements and growth in skeletal muscle post exercise. We utilized global gene profiling to identify novel signaling pathways and patterns of gene expression involved in this adaptation process, and found the alpha7BX2 integrin initiates transcription of genes that allow for protection from stress and modulation of protein synthesis.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6887

24 Samples

Download data: TXT

(Submitter supplied) To improve our understanding of the genetic reprogramming during the early phase of skeletal adaptation in response to endurance training, we employed cDNA microarray analysis to examine changes in mRNA expression in mouse plantaris muscle after a single bout voluntary running. Control untrained mice were compared with with R3h, R12h, P3h, P6h, P12h, P24h and R4w mice. We conclude that a single bout of voluntary running is sufficient to induce active remodeling processes, including cell proliferation, by a coordinated regulation of the genome in response to signals elicited from increased neuromuscular activity. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS1019

Platform:

GPL254

7 Samples

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(Submitter supplied) The 16K mouse cDNAs probes used in this microarray were designed using sequence information gathered from RIKEN FANTOM cDNA library. Probes can be 0.5 to 3 kb in length where about 60% of the probes represent full length transcripts. The PCR products were inkjet-printed on the array by Agilent Technologies (Palo Alto, CA).

Organism:

Mus musculus

35 DataSets

48 Series

641 Samples

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Analysis of plantaris muscle following a bout of voluntary running for 12 hours. Gene expression examined at various time points up to 24 hours following cessation of running. Results provide insight into molecular events occuring during the early phase of adaptation to endurance training.

Organism:

Mus musculus

Type:

Expression profiling by array, log ratio, 3 protocol, 5 time sets

Platform:

GPL254

Series:

GSE2001

7 Samples

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(Submitter supplied) 10 male subjects performed ~45 min one-legged cycling and 4 x 7 maximal concentric-eccentric knee extensions for each leg 15 min later. Thus, one limb performed aerobic and resistance exercise (AE+RE), while the opposing leg did resistance exercise only (RE). Biopsies were obtained from m. vastus lateralis of each leg 3 h after the resistance exercise bout. Gene expression analysis was carried out on the Affymetrix HuGene-2.1-st platform.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL17692

20 Samples

Download data: CEL

(Submitter supplied) Purpose: The aim of this study is to investigate the translational regulation of skeletal muscle during acute endurance exercise. Methods: We used mRNA-Seq and ribosome profiling to examine transcriptional and translational regulation, respectively. Result: There were clear distinctions between the profiles of transcription and translation even at a basal condition. TOP-motif genes were translationally suppressed immediately after the exercise. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing; Other

Platform:

GPL16331

8 Samples

Download data: TXT

(Submitter supplied) To further understand molecular mechanisms underlying skeletal muscle hypertrophy, expression profiles of translationally and transcriptionally regulated genes were characterized following an acute bout of maximally activated eccentric contractions. Experiments demonstrated that translational mechanisms contribute to acute gene expression changes following high resistance contractions with two candidate mRNAs, basic fibroblast growth factor (bFGF) and elongation factor-1 alpha (EF1alpha), targeted to the heavier polysomal fractions after a bout of contractions. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS278

Platform:

GPL85

36 Samples

Download data: CEL

Trancriptionally and translationally-regulated gene expression underlying skeletal muscle hypertrophy induced by acute maximally activated eccentric contractions. Total RNA or polysomal RNA examined at one and six hours post contraction.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 protocol, 2 specimen, 3 time sets

Platform:

GPL85

Series:

GSE467

36 Samples

Download data: CEL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Sus scrofa

Type:

Expression profiling by array

Platform:

GPL5972

76 Samples

Download data: GPR

(Submitter supplied) Acute physical exercise elicits changes in gene expression in skeletal muscles to promote metabolic changes and to repair exercise-induced muscle injuries. Here, we investigated the impact of a single bout of running exercise until exhaustion on global transcriptional profiles in porcine skeletal muscles. Using a combined microarray and candidate gene approach, we identified a suite of genes that are differentially expressed in muscles during post-exercise recovery. more...

Organism:

Sus scrofa

Type:

Expression profiling by array

Platform:

GPL5972

39 Samples

Download data: GPR

(Submitter supplied) Acute physical exercise elicits changes in gene expression in skeletal muscles to promote metabolic changes and to repair exercise-induced muscle injuries. Here, we investigated the impact of a single bout of running exercise until exhaustion on global transcriptional profiles in porcine skeletal muscles. Using a combined microarray and candidate gene approach, we identified a suite of genes that are differentially expressed in muscles during post-exercise recovery. more...

Organism:

Sus scrofa

Type:

Expression profiling by array

Platform:

GPL5972

37 Samples

Download data: GPR

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL9454 GPL570

65 Samples

Download data: CEL

(Submitter supplied) Regulated in DNA Damage and Development 1 (REDD1) is a stress induced protein whose expression is highly induced in skeletal muscle following a single bout of aerobic exercise. However, the role of this induction is unknown We used microarrays to detail the change in gene signature within skeletal muscle following a single bout of aerobic exercise in wild type and REDD1 null mice

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL16570

12 Samples

Download data: CEL

(Submitter supplied) Mammalian skeletal muscle contains heterogenous myofibers with different contractile and metabolic properties that sustain muscle mass and endurance capacity. The transcriptional regulators that govern these myofiber gene programs have been elucidated. However, the hormonal cues that direct the specification of myofiber types and muscle endurance remain largely unknown. Here we uncover the secreted factor Tsukushi (TSK) as an extracellular signal that is required for maintaining muscle mass, strength, and endurance capacity, and contributes to muscle regeneration. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL28430

6 Samples

Download data: CSV

(Submitter supplied) The pathophysiological effects of a number of metabolic and age-related disorders can be prevented to some extent by exercise and increased physical activity. However, the molecular mechanisms that contribute to the beneficial effects of muscle activity remain poorly explored. Availability of a fast, inexpensive, and genetically tractable model for muscle activity and exercise will allow rapid identification and characterization of the molecular mechanisms that mediate the beneficial effects of muscle activity. more...

Organism:

Drosophila melanogaster

Type:

Expression profiling by high throughput sequencing

Platform:

GPL17275

6 Samples

Download data: XLSX