Similar studies for GEO DataSets (Select 200131868) - GEO DataSets

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Items: 20

Select item 2001318681.

RNA sequencing of mouse hepatic response to compounds with predicted lifespan-extending effect

(Submitter supplied) This dataset consists of hepatic gene expression profiles of mice subjected to 4 compounds predicted by Connectivity Map (CMap) using gene signatures identified for known lifespan-extending interventions: ascorbyl-palmitate, KU-0063794, AZD8055 and rilmenidine. Corresponding age-, sex- and strain-matched littermate controls are also presented. Using this data, we confirmed the association between longevity signatures and gene expression response to the predicted compounds in vivo, using the same mouse model as for the identification of gene signatures associated with lifespan extension. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
24 Samples

Download data: TXT

Series

Accession:: GSE131868

ID:: 200131868

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Select item 2001319012.

Identification and application of gene expression signatures associated with lifespan extension

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL17021 GPL24247
102 Samples

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Series

Accession:: GSE131901

ID:: 200131901

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Select item 2001317543.

RNA sequencing of mouse hepatic response to lifespan-extending interventions

(Submitter supplied) This dataset consists of hepatic gene expression profiles of mice subjected to 8 different lifespan-extending interventions, together with the corresponding age-, sex- and strain-matched littermate controls: caloric restriction (CR), methionine restriction (MR), growth hormone receptor knockout (GHRKO), Snell dwarf mice (Pit1 -/-), rapamycin, acarbose, 17-alpha-estradiol (17aE2) and Protandim. Both sexes and different age groups are presented within dataset. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
78 Samples

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Series

Accession:: GSE131754

ID:: 200131754

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Select item 2002273604.

Distinct longevity mechanisms across and within species and their association with aging

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Macaca fascicularis; Mus musculus; Murina leucogaster; Peromyscus leucopus; Tamias sibiricus; Papio anubis; Ursus americanus; Petaurus breviceps; Castor canadensis

Type:: Expression profiling by high throughput sequencing

9 related Platforms
90 Samples

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Series

Accession:: GSE227360

ID:: 200227360

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Select item 2002273595.

Gene expression signatures of mammalian longevity across species

(Submitter supplied) Lifespan varies both within and across species, but the general principles of its control are not understood. To identify transcriptomic signatures of mammalian longevity, we sequenced multiple organs of young adult mammals corresponding to 8 different species, including Canadian beaver, long-tailed macaque, greater tube-nosed bat, baboon, white-footed mouse, sugar glider, Siberian chipmunk and American black bear. more...

Organism:: Petaurus breviceps; Murina leucogaster; Papio anubis; Ursus americanus; Peromyscus leucopus; Tamias sibiricus; Macaca fascicularis; Castor canadensis

Type:: Expression profiling by high throughput sequencing

8 related Platforms
48 Samples

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Series

Accession:: GSE227359

ID:: 200227359

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Select item 2002273586.

RNA sequencing of mouse liver and kidney after 1-month treatment with predicted longevity compounds

(Submitter supplied) This dataset consists of liver and kidney gene expression profiles of young UM-HET3 mice subjected to the following compounds for 1 month: AS-703026 (liver and kidney), enzastaurin (liver and kidney), GDC-0941 (liver and kidney), ascorbyl-palmitate (kidney), AZD8055 (kidney) and KU0063794 (kidney). Corresponding age-, sex- and strain-matched littermate controls for kidney are also presented. This dataset complements liver RNAseq profiles of control UM-HET3 mice and mice subjected to ascorbyl-palmitate, AZD8055 and KU0063794 (collected and sequenced at the same time) stored at GSE131868.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
42 Samples

Download data: CSV

Series

Accession:: GSE227358

ID:: 200227358

PubMed Similar studies

Select item 2000483347.

The effect of Rapamycin on the transcriptome of old mouse liver

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6885
111 Samples

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Series

Accession:: GSE48334

ID:: 200048334

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Select item 2000483338.

The effect of chronic Rapamycin on the transcriptome of old mouse liver

(Submitter supplied) Analysis of the effect of gene expression in the livers of old mice (25 months of age) fed rapamycin chronically (21 months) from 4 months of age.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6885
69 Samples

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Series

Accession:: GSE48333

ID:: 200048333

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Select item 2000483319.

The effect of short term Rapamycin on the transcriptome of old mouse liver

(Submitter supplied) Analysis of the effect of gene expression in the livers of old mice (25 months of age) fed rapamycin short term (6 months) Rapamycin from 19 months of age.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6885
42 Samples

Download data: TXT

Series

Accession:: GSE48331

ID:: 200048331

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Select item 20004186010.

Time-course expression data during assurance of the chronological longevity by caloric restriction in budding yeast

(Submitter supplied) Caloric restriction (CR) is the only non-genetic intervention to retard aging and increase longevity in a variety of species. It is important to understand the fundamental mechanism by which CR extends lifespan that remains elusive. Owing to well-established genomic tools and convenience of culture system, we used a single cell organism, Saccharomyces cerevisiae, to clarify the mechanisms of CR. In order to identify genes responsible for CR-mediated longevity, we performed microarray experiments across the longevity assurance time-points.

Organism:: Schizosaccharomyces pombe; Saccharomyces cerevisiae BY4741; Saccharomyces cerevisiae

Type:: Expression profiling by array

Platform:: GPL2529
24 Samples

Download data: CEL, CHP

Series

Accession:: GSE41860

ID:: 200041860

Select item 20006433611.

Expression data of worms under different caloric restriction mimetic treatments

(Submitter supplied) We used microarray analysis to further our understanding of the mode of action of the well know caloric restriction mimetic rapamycin and the compound Allantoin first studied in the context of aging in this study. His work helps build on our understanding of potential caloric restriction mimetics predicted from our bioinformatic aproach of quering the Connectivity Map, a database of drug-induced gene expression profiles, using the transcriptional profile of CR to identify drugs that induce a similar or opposite gene expression profile.

Organism:: Caenorhabditis elegans

Type:: Expression profiling by array

Platform:: GPL200
15 Samples

Download data: CEL

Series

Accession:: GSE64336

ID:: 200064336

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Select item 20004101812.

Rapamycin extends life span, but has limited effects on aging in mice

(Submitter supplied) Rapamycin extends life span in mice, but it remains unclear if this compound also delays mammalian aging. Here, we present results from a comprehensive large-scale assessment of a wide rage of structural and functional aging phenotypes in mice. Rapamycin extended life span but showed few effects on a large number of systemic aging phenotypes, suggesting that rapamycin's effects on aging are largely limited to the regulation of age-related mortality and carcinogenesis.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6885
30 Samples

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Series

Accession:: GSE41018

ID:: 200041018

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Select item 20008927513.

Diverse interventions that extend mouse lifespan suppress shared age-associated epigenetic changes at critical gene regulatory regions

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Methylation profiling by high throughput sequencing

Platforms:: GPL21103 GPL19057
48 Samples

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Series

Accession:: GSE89275

ID:: 200089275

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Select item 20008927414.

Diverse interventions that extend mouse lifespan suppress shared age-associated epigenetic changes at critical gene regulatory regions (WGBS 2)

(Submitter supplied) Investigation into changes in the methylome in rapamycin and caloric restriction in aged mice.

Organism:: Mus musculus

Type:: Methylation profiling by high throughput sequencing

Platform:: GPL21103
16 Samples

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Series

Accession:: GSE89274

ID:: 200089274

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Select item 20008927215.

Diverse interventions that extend mouse lifespan suppress shared age-associated epigenetic changes at critical gene regulatory regions (RNA-Seq)

(Submitter supplied) Investigation into changes in the methylome in young (2 months) and aged (22 months) Ames dwarf (Prop1 Hom) and WT (Prop1 Het) mice

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
16 Samples

Download data: CSV

Series

Accession:: GSE89272

ID:: 200089272

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Select item 20003863516.

Expression data from dietary restricted budding yeast

(Submitter supplied) Dietary restriction (also known as caloric/calorie restriction; CR) extends the lifespan of species from all three eukaryotic kingdoms. The restriction of the diet interferes directly with the aging process by triggering a tightly controlled genetic program where specific sets of genes are either upregulated downreguled. We used microarray-technology to detail the global program of gene expression underlying the anti-aging effect of dietary restriction and identified distinct classes of up- and down-regulated genes.

Organism:: Saccharomyces cerevisiae; Schizosaccharomyces pombe

Type:: Expression profiling by array

Platform:: GPL2529
2 Samples

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Series

Accession:: GSE38635

ID:: 200038635

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Select item 20004097717.

Combined treatment of rapamycin and dietary restriction has a larger effect on the transcriptome and metabolome of liver

(Submitter supplied) Rapamycin (Rapa) and dietary restriction (DR) have consistently been shown to increase lifespan. To investigate whether Rapa and DR affect similar pathways in mice, we compared the effects of feeding mice ad libitum (AL), Rapa, DR, or a combination of Rapa and DR (Rapa + DR) on the transcriptome and metabolome of the liver. The principal component analysis shows that Rapa and DR are distinct groups. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6885
46 Samples

Download data: TXT

Series

Accession:: GSE40977

ID:: 200040977

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Select item 20012013718.

A multi-tissue full lifespan epigenetic clock for mice

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Methylation profiling by high throughput sequencing; Third-party reanalysis

Platforms:: GPL21103 GPL17021
549 Samples

Download data: CSV, TXT

Series

Accession:: GSE120137

ID:: 200120137

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Select item 20012013619.

A multi-tissue full lifespan epigenetic clock for mice [II]

(Submitter supplied) Human DNA-methylation data have been used to develop highly accurate biomarkers of aging ("epigenetic clocks"). Recent studies demonstrate that similar epigenetic clocks for mice (Mus Musculus) can be slowed by gold standard anti-aging interventions such as calorie restriction and growth hormone receptor knock-outs. Using DNA methylation data from previous publications with data collected in house for a total 1189 samples spanning 193,651 CpG sites, we developed 4 novel epigenetic clocks by choosing different regression models (elastic net- versus ridge regression) and by considering different sets of CpGs (all CpGs vs highly conserved CpGs). more...