GEO DataSets

Analysis of hypothalamic hamartomas (HHs) from patients with or without central precious puberty (CPP). HHs are congenital lesions composed of neurons and astroglia often associated with CPP. Results provide insight into the mechanisms that initiate normal puberty.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 development stage, 2 disease state, 2 gender sets

Platform:

GPL96

Series:

GSE7142

4 Samples

Download data: CEL, EXP

(Submitter supplied) Hypothalamic hamartomas (HHs) are congenital lesions of the neuroendocrine brain composed of neurons and astroglia. Frequently, HHs are associated with central precocious puberty (CPP) and/or gelastic seizures. Because HHs might express genes similar to those required for the initiation of normal puberty we used cDNA arrays to compare the gene expression profile of a HH associated with CPP with three HHs not accompanied by sexual precocity. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3110

Platform:

GPL96

4 Samples

Download data: CEL, EXP

(Submitter supplied) d-serine is naturally present throughout the human body. It is also used as add-on therapy for treatment-refractory schizophrenia. d-Serine interacts with the strychnine-insensitive glycine binding site of NMDA receptor, and this interaction could lead to potentially toxic activity (i.e., excitotoxicity) in brain tissue. The transcriptomic changes that occur in the brain after d-serine exposure have not been fully explored. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS3643

Platform:

GPL1355

24 Samples

Download data: CEL

Analysis of forebrains of animals treated with up to 500 mg/kg D-serine for 96 hours. D-serine is involved in many physiological processes through its interaction with the glycine binding site of the NMDA receptor. Results provide insight into the impact of D-serine exposure on neuronal functions.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 agent, 6 dose sets

Platform:

GPL1355

Series:

GSE10748

24 Samples

Download data: CEL

(Submitter supplied) Gender dependent gene expression in the kidney of 36 day old rats using the Affymetrix GeneChip rat expression set 230 array RAE230A. mixed model ANOVA using log2 transformed signal intensity of PM. Keywords: repeat

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL3240

18 Samples

Download data: CEL

(Submitter supplied) The alkylating agent N-methyl-N’-nitro-N-nitrosoguanidine (MNNG) induces cellular DNA damages and other comprehensive alterations that lead to chromosomal aberrations, mutations, tumor initiations, and cell death. However, the molecular mechanism of MNNG-induced cellular stress remains unclear.We have genome-wide analyzed early transcriptional responses of human FL amnion epithelial cells after exposure to three relatively low doses of MNNG (0.2, 1.0, and 10.0µM),and differential gene expression profiles were obtained 4 h after exposure using oligonucleotide microarrays followed by validation with quantitative real-time RT-PCR. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL96 GPL97

16 Samples

Download data: CEL, EXP

(Submitter supplied) This report is based on an ongoing study to examine gene expression differences in monkey lateral geniculate nucleus (LGN). For this study, samples from an Old World species, vervet monkey (Cercopithecus aethiops), were cross-hybridized to the Rhesus Macaque Genome Array (Affymetrix). Microarray analysis was performed using laser capture microdissected populations of individual neuronal cell bodies isolated from the LGN compared to heterogeneous samples from whole lamina. more...

Organism:

Macaca mulatta; Homo sapiens; Chlorocebus aethiops vervet

Type:

Expression profiling by array

Platforms:

GPL3535 GPL570

14 Samples

Download data: CEL, CHP, EXP

(Submitter supplied) Transcriptional profilling of the female primate hypothalamus during normal puberty. Total RNA samples from hypothalami from juvenile (JUV), early pubertal (EP) and mid pubertal (MP) female monkeys were used to compare pairwise against the JUV group. Keywords: Normal gene expression profiling

Organism:

Macaca mulatta; Homo sapiens

Type:

Expression profiling by array

Platform:

GPL5572

8 Samples

Download data: TXT