Similar studies for GEO DataSets (Select 4193) - GEO DataSets

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Items: 12

Select item 41931.

Quiescent systemic lupus erythematosus: peripheral blood B cells

Analysis of B cells sorted from the peripheral blood of patients with quiescent lupus (inactive > 6 months). B cell activation and production of a wide variety of autoantibodies appear central to lupus development. Results provide insight into molecular mechanisms underlying systemic lupus.

Organism:: Homo sapiens

Type:: Expression profiling by array, transformed count, 2 disease state sets

Platform:: GPL570
Series:: GSE30153
26 Samples

Download data: CEL

DataSet

Accession:: GDS4193

ID:: 4193

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 2000301532.

B cell signature during inactive systemic lupus

(Submitter supplied) Systemic lupus erythematosous (SLE) is an autoimmune disease with an important clinical and biological heterogeneity. B lymphocytes appear central to the development of SLE which is characterized by the production of a large variety of autoantibodies and hypergammaglobulinemia. In mice, immature B cells from spontaneous lupus prone animals are able to produce autoantibodies when transferred into immunodeficient mice, strongly suggesting the existence of intrinsic B cell defects during lupus. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS4193
Platform:: GPL570
26 Samples

Download data: CEL, TXT

Series

Accession:: GSE30153

ID:: 200030153

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000587563.

Cell intrinsic expression of TLR9 in autoreactive B cells constrains BCR/TLR7-dependent responses

(Submitter supplied) Endosomal Toll-like receptors (TLRs) play an important role in the etiology of systemic autoimmune diseases such as SLE, where DNA- and RNA-associated autoantigens activate autoreactive B cells through TLR9- and TLR7-dependent pathways, respectively. Nevertheless, TLR9-deficient autoimmune prone mice develop more severe clinical disease, while TLR7-deficient and TLR7/9-double deficient autoimmune-prone mice develop less severe disease. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL13912
16 Samples

Download data: TXT

Series

Accession:: GSE58756

ID:: 200058756

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000066744.

Gene expression program of AM-14 B cells stimulated through the B cell receptor (BCR) and/or Toll-like receptors (TLR)

(Submitter supplied) We have previously shown that rheumatoid factors (RF) produced by Fas-deficient autoimmune-prone mice typically bind autologous IgG2a with remarkably low affinity. Nevertheless, B cells representative of this RF population proliferate vigorously in response IgG2a/chromatin immune complexes through a mechanism dependent on the sequential engagement of the BCR and Toll-like receptor 9 (TLR9). To more precisely address the role of both receptors in this response, we analyzed the signaling pathways activated in AM14 B cells stimulated with these complexes. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
15 Samples

Download data: CEL

Series

Accession:: GSE6674

ID:: 200006674

Select item 2001402775.

Loss of epigenetic modifications on the inactive X chromosome and sex-biased gene expression profiles in B cells from NZB/W F1 mice with lupus-like disease

(Submitter supplied) We report loss of epigentic silencing marks on the inactive X on female mice with lupus like disease, and find novel sex differences in gene expression between female and male mice with late stage disease.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
6 Samples

Download data: CSV

Series

Accession:: GSE140277

ID:: 200140277

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000503956.

Gene profiling reveals specific molecular pathways in the pathogenesis of atherothrombosis in Antiphospholipid syndrome, Systemic Lupus Erythematosus and Lupus with Antiphospholipid Syndrome

(Submitter supplied) The present gene expression array study of comparative gene profile in monocytes from patients with primary Antiphospholipid Syndrome, Systemic Lupus Erythematosus and Lupus with Antiphospholipid Syndrome demonstrates that the gene expression profiling allows the segregation of these highly related autoimmune diseases, with specific signatures explaining the pro-atherosclerotic, pro-thrombotic and inflammatory changes.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL4133
12 Samples

Download data: TXT

Series

Accession:: GSE50395

ID:: 200050395

Select item 2000801837.

RNA-seq study reveals unique transcriptome expression in systemic lupus erythematosus patients with distinct autoantibody profile

(Submitter supplied) Systemic lupus erythematosus patients exhibit remarkable heterogeneity in clinical manifestations and autoantibody repertoires. This complexity poses major barrier in diagnosis and effective treatment of SLE. To address this we studied the SLE patients in groups categorized on the basis of distinct sera autoantibodies. SLE patients were segregated into three group based on the presence of autoantibodies against i) dsDNA only ii) ENA (extractable nuclear antigens) only or iii) both.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL11154
16 Samples

Download data: XLSX

Series

Accession:: GSE80183

ID:: 200080183

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 2001106478.

Ets1 suppresses the expression of key TFH genes to block TFH differentiation

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL17021 GPL19057
16 Samples

Download data: BIGWIG, TXT

Series

Accession:: GSE110647

ID:: 200110647

PubMed Similar studies

Select item 2001105959.

Upregulation of TFH profile in absence of Ets1 expression

(Submitter supplied) To characterize the effect of loss of Ets1 in Non-TFH and TFH cells, we performed gene expression RNAseq analysis for T follicular helper (TFH) and Non-T follicular helper (Non-TFH) cells in WT (Ets1 fl/fl) and Ets1 KO (CD4-cre Ets1 fl/fl) mice.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
12 Samples

Download data: TXT

Series

Accession:: GSE110595

ID:: 200110595

PubMed Similar studies SRA Run Selector

Select item 20011059410.

Ets1 modulates epigentic landscape of key TFH genes in T naïve cells

(Submitter supplied) Ets1 can directly bind key TFH genes, regulating their expression . Loss of Ets1 results in the pre-mature expression of TFH-genes in Non-TFH cells. We wished to analyze if loss of Ets1 correlated with changes in chromatin accessibility especially in TFH gene loci.

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL17021
4 Samples

Download data: BIGWIG

Series

Accession:: GSE110594

ID:: 200110594

PubMed Similar studies SRA Run Selector

Select item 20011060711.

Twin DNA methylation profiling reveals flare-dependent interferon signature and B-cell promoter hypermethylation in systemic lupus erythematosus

(Submitter supplied) Objective: Systemic lupus erythematosus (SLE) has limited monozygotic (MZ) twin concordance, implying a role for other pathogenic factors than genetic variation, such as epigenetic changes. Using the disease discordant twin model, we investigated genome-wide DNA methylation changes in sorted CD4+ T-cells, monocytes, granulocytes and B-cells in twin pairs with at least one SLE-affected twin. Methods: Peripheral blood from 15 SLE twin pairs (six MZ, nine dizygotic (DZ)) was processed using gradient density centrifugation for the granulocyte fraction. more...

Organism:: Homo sapiens

Type:: Methylation profiling by genome tiling array

Platform:: GPL13534
104 Samples

Download data: CSV, IDAT

Series

Accession:: GSE110607

ID:: 200110607

Select item 20013508712.

Bach2 deficiency leads to spontaneous expansion of IL-4-producing T follicular helper cells and autoimmunity

(Submitter supplied) The transcription factor Bach2 is a critical negative regulator of Tfh cell differentiation, especially IL-4 subset. Tfh cells from the mesenteric lymph nodes of WT and Bach2 CD4 conditional KO mice were collected to process the Rna-seq. Mechanistically, Bach2 may limit abnormal IL-4-produicng Tfh cell formation by repressing c-Maf, CXCR5 and IL-4.